المؤلفون: A.K. Janmeja, D. Chatterjee, J.R. Kashyap, D. Aggarwal, A. Tahlan, S. Ragaselvi

المصدر: The Indian Journal of Chest Diseases and Allied Sciences. 62:9-12

مصطلحات موضوعية: General Medicine

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::0f98391587e94975078e956eb5a951feTest
https://doi.org/10.5005/ijcdas-62-1-9Test

المؤلفون: D. CHATTERJEE, S. MONDAL, D. BASU

المصدر: Journal of Crop and Weed. 18:218-222

مصطلحات موضوعية: General Medicine

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::ee09249f34591b8897471e35040b6defTest
https://doi.org/10.22271/09746315.2022.v18.i3.1639Test

المؤلفون: A Aruni, SS Nagaraj, S Deivasigamani, A Chowdhury, H Kumar, D Chatterjee

المصدر: Annals of the Royal College of Surgeons of England.

مصطلحات موضوعية: Surgery, General Medicine

الوصف: Oesophageal carcinosarcoma (OCS) is a rare oesophageal cancer, expressing both carcinomatous and sarcomatous elements. Although believed to have a better prognosis, no standard guidelines exist for its diagnosis and management. We report a case of a 60-year male presenting with progressive dysphagia and weight loss. Endoscopy and contrast-enhanced computed tomography of the chest revealed a large polypoidal intraluminal growth at the mid-oesophagus. Endoscopic biopsy revealed a sarcoma of the oesophagus. The patient underwent McKeown minimally invasive oesophagectomy. Final histopathology was suggestive of OCS. Postoperatively, the patient received adjuvant chemoradiation. At 20-month follow-up, he was asymptomatic with no radiological evidence of recurrence.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aeadd57e9ae230907c9b233ba1f27e90Test
https://pubmed.ncbi.nlm.nih.gov/36622226Test

المؤلفون: J. Liang, Iman Azam Ghavami, E. Cocchi, D. Chatterjee, J. Zhang, R. Gras, Ali G. Gharavi, M. M. Morban, G. Lab, A. Mo, J. Zheng, K. O. Stevens, J. Lewis, Maddalena Marasa, Stacy Piva, J. S. Kim, G. Jin, Byum Hee Kil, V. M. Nicasio, M. Elliott

المصدر: J Am Soc Nephrol

مصطلحات موضوعية: Male, 0301 basic medicine, Transcription, Genetic, 030232 urology & nephrology, Apoptosis, urologic and male genital diseases, medicine.disease_cause, Genetic analysis, Serology, Mice, Liver disease, 0302 clinical medicine, Catalytic Domain, RNA-Seq, Exome, Fisher's exact test, Mice, Knockout, General Medicine, Polycystic Kidney, Autosomal Dominant, female genital diseases and pregnancy complications, Phenotype, Nephrology, embryonic structures, Cohort, symbols, Medical genetics, Female, DNA Replication, medicine.medical_specialty, TRPP Cation Channels, 03 medical and health sciences, symbols.namesake, Internal medicine, CDC2 Protein Kinase, Exome Sequencing, medicine, Animals, Crosses, Genetic, Cell Proliferation, urogenital system, business.industry, Gene Expression Profiling, Pyruvate Dehydrogenase Acetyl-Transferring Kinase, Immune dysregulation, medicine.disease, Mice, Inbred C57BL, Basic Research, 030104 developmental biology, Gene Expression Regulation, Mutation, business

الوصف: Background: Patients with preexisting chronic kidney (CKD) and liver disease and liver are more at risk from COVID-19, but reasons for variability in disease susceptibility and severity is still poorly understood. Given the high infection rate in New York City, we conducted a COVID-19 assessment survey in a cohort of CKD and liver patients previously consented into genetic studies. Methods: Between March and August 2020, we completed 1601 unique IRBapproved COVID-19 assessment surveys. The survey covered COVID-19 symptoms, exposure risk, PCR and/or serology testing, and hospitalization. 298 of those patients were exome sequenced. We analyzed differences in COVID-19 PCR, serology and hospitalization rate and genetic analysis to identify possibly associated variants in the immune/coagulation pathways, suggested to be involved in COVID-19 susceptibility/ severity by recent publicationw. We also analyzed variants based on the American College of Medical Genetics and Genomics (ACMG) guidelines for clinical annotation of genetic results Results: Hispanic/Latino patients were more likely to have a positive COVID-19 PCR (Fisher Exact Test p: 0.01, 29.5% vs 16.7%), serology (Fisher Exact Test p: 0.02, 22.9% vs 9.7%) and hospitalization (Fisher Exact Test p: 0.01, 29.5% vs 16.7%). Patients with glomerulopathy had lower positive COVID-19 PCR tests (Fisher Exact Test p: 0.01, 14.7% vs 48.7%). Analysis of exome data identified an excess number of rare variants in genes in the immune dysregulation pathways among patients with positive COVID-19 PCR test, (fisher p: 0.01, 75% vs 18%). These results were mostly driven by rare variants in CASP10, which were more common among the Hispanic/Latino population. Conclusions: We confirm that Hispanic/Latino ethnicity is a significant risk factor for positive COVID-19 PCR, serology and hospitalization. The analysis of the genetic mechanisms in immune/coagulation pathways identified an excess of rare variants in the CASP10 gene, results that overlap with Hispanic/Latino ethnicity.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de6dd56df6e631b2264a99032dd42926Test
https://doi.org/10.1681/asn.2020040511Test

المؤلفون: Hong Zhuang, A.D. Maxwell, Brian Bowker, D. Chatterjee, Koushik Adhikari

المصدر: Poultry Science. 97:2971-2978

مصطلحات موضوعية: 0301 basic medicine, Dorsum, Meat, 0402 animal and dairy science, Broiler, Marination, 04 agricultural and veterinary sciences, General Medicine, Biology, 040201 dairy & animal science, Sensory analysis, Pectoralis Muscles, 03 medical and health sciences, 030104 developmental biology, Muscular Diseases, Chewiness, Animals, Animal Science and Zoology, Cooking, Food science, Muscle composition, Fillet (mechanics), Chickens, Poultry Diseases, Flavor

الوصف: The wooden breast (WB) myopathy influences muscle composition and texture characteristics in broiler breast meat. It is unknown if marination reduces the negative influence of WB on meat sensory quality or if WB effects are uniform throughout the Pectoralis major. The objective of this study was to determine the effects of marination on the sensory attributes and instrumental shear force measurements of the ventral (skin-side) and dorsal (bone-side) portions of normal and severe WB meat. Sixty butterfly fillets (30 normal and 30 severe WB) were selected from the deboning line of a commercial processing plant. Individual fillets were portioned into ventral and dorsal halves. Portions from one side of each butterfly were used as non-marinated controls, and portions from the other side were vacuum-tumble marinated (16 rpm, -0.6 atm, 4°C, 20 min) with 20% (wt/wt) marinade to meat ratio. Marinade was formulated to target a concentration of 0.75% (w/v) salt and 0.45% (w/v) sodium tripolyphosphate in the final product. Descriptive sensory analysis (9 trained panelists) was conducted to evaluate visual, texture, and flavor attributes (0-15 point scale) of breast portions along with Warner-Bratzler shear force. Significant interaction effects between WB and marination were not observed for the sensory attributes. Greater springiness, cohesiveness, hardness, fibrousness, and chewiness scores were observed in WB samples (P0.001). Marination decreased cohesiveness, hardness, and chewiness (P0.05) and increased juiciness (P = 0.002). The effects of WB on sensory texture attributes were more apparent in the ventral portions of the breast fillets. Flavor attributes (salty and brothy) increased (P0.001) with marination. In non-marinated samples, shear force was similar between normal and WB samples. In marinated samples, however, shear force was greater (P0.001) in WB samples. Data suggest that the WB effect on meat sensory quality is not uniform throughout the Pectoralis major and that WB-related differences in cooked meat sensory texture attributes are lessened but not eliminated by vacuum-tumbling marination.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::774356b1f55d776082e47bd653311aa3Test
https://doi.org/10.3382/ps/pey145Test

المؤلفون: Sunil K Narayan, D Chatterjee, Krishnan Nagarajan, R Lakshmi Narasimhan

المصدر: Brain Circulation
Brain Circulation, Vol 6, Iss 2, Pp 107-115 (2020)

مصطلحات موضوعية: medicine.medical_specialty, lcsh:Diseases of the circulatory (Cardiovascular) system, lcsh:Medical technology, Collateral circulation, medicine.diagnostic_test, business.industry, General Medicine, medicine.disease, regional leptomeningeal collateral score, lcsh:R855-855.5, Informed consent, Modified Rankin Scale, lcsh:RC666-701, Ischemic stroke, Angiography, medicine, ischemic stroke, Original Article, Radiology, business, Acute ischemic stroke, Stroke, computed tomography angiography, Computed tomography angiography

الوصف: PURPOSE: The aim of the study is to assess the correlation between regional leptomeningeal collateral (rLMC) Scores calculated on computed tomography (CT) angiography following acute anterior circulation ischemic stroke, with 3-month clinical outcome measured as modified Rankin Scale (mRS) and Barthel Index (BI). MATERIALS AND METHODS: A total of thirty patients were studied as per the exclusion and inclusion criteria and after informed consent. Multi-phase CT angiography was carried out within 24 h of stroke onset, and collateral scoring was done using rLMC score along with Alberta stroke programme early CT (ASPECT) scoring. At 3 months, patients were followed up to evaluate the clinical outcome using mRS and BI. Statistical analysis was performed to find out the correlation between rLMC score, ASPECT score, and clinical outcome and for association with demographic parameters and stroke risk factors. RESULTS: A strong correlation was noted between ASPECT and rLMC scores (P < 0.001) and between rLMC scores and clinical outcome at 3 months (mRS and BI). Correlation with mRS (P < 0.001) was nearly as strong as that of BI on follow-up (P < 0.001). The ASPECT score also was a predictor of clinical outcome and showed correlation with mRS (P < 0.001) and BI (P < 0.001). No significant association was found between various stroke risk factors and demographic parameters with rLMC scores. The rLMC scoring system showed substantial inter-rater reliability with Kappa = 0.7. CONCLUSIONS: rLMC score in CT angiography correlates with ASPECT Score and clinical outcome at 3 months. Hence, this scoring system can be used for collateral quantification as may be of use in predicting short-term clinical outcomes.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::86d8da428778e34c60faba117dd264b6Test
https://pubmed.ncbi.nlm.nih.gov/33033780Test

المؤلفون: G. Sanchez-Brambila, Angela M. Rincon, Hong Zhuang, D. Chatterjee, Brian Bowker

المصدر: Poultry Science. 95:2449-2454

مصطلحات موضوعية: Veterinary medicine, Meat, Chemistry, 0402 animal and dairy science, Broiler, food and beverages, 04 agricultural and veterinary sciences, General Medicine, 040401 food science, 040201 dairy & animal science, Pectoralis Muscles, 0404 agricultural biotechnology, Food Storage, Chewiness, Texture profile analysis, Freezing, Animals, Animal Science and Zoology, Cooking, Food science, Texture (crystalline), Chickens, Normal breast

الوصف: The objective was to characterize texture properties of raw and cooked broiler fillets (Pectoralis major) with the wooden breast condition (WBC) using the instrumental texture techniques of Meullenet-Owens Razor Shear (MORS) and Texture Profile Analysis (TPA). Deboned (3 h postmortem) broiler fillets were collected from a commercial plant and categorized as normal, moderate, or severe WBC based on the incidence and severity of diffuse hardened areas throughout fillets and the degree of palpable hardness. The fillets were then either stored at 4°C overnight or in a -20°C freezer. The MORS and TPA of the raw samples were determined at 24 h postmortem for fresh samples and after thawing overnight for frozen samples. The same measurements were also taken after the samples were cooked to 78°C. Regardless of freshness (fresh vs. frozen-thawed), cooking (raw vs. cooked), and degree of WBC, both MORS force and energy of the WBC samples were higher than that of the normal samples (P 0.05). For TPA adhesiveness and resilience, there were no differences between normal and WBC samples (P 0.05). However, average TPA hardness and chewiness measurements of the fillets with WBC were higher than the normal fillets (P 0.05). Regardless of texture measurement, there were no interactions between freshness and the wooden condition or no differences between moderate and severe WBC fillets (P 0.05). These results demonstrate that there are significant differences in instrumental texture properties between normal fillets and those exhibiting the WBC. The WBC fillets required more force to cut through, harder, and chewier than normal breast muscles. These results suggest that cooked WBC meat would likely be tougher than cooked normal meat.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::da062d3d13e45c1190bf4148d25d61c2Test
https://doi.org/10.3382/ps/pew204Test

المؤلفون: Hong Zhuang, B. C. Bowker, G Sanchez-Brambilia, D Chatterjee

مصطلحات موضوعية: Abstracts, Quality assessment, Genetics, Broiler, food and beverages, Animal Science and Zoology, Sensory system, General Medicine, Food science, Biology, Texture (geology), Food Science

الوصف: The woody breast (WB) condition is an emerging myopathy found in broiler breast Pectoralis major. It greatly influences the texture characteristics and quality of raw meat. The objective of this study was to evaluate the effects of WB on the sensory quality of cooked intact and ground broiler breast meat. Broiler breast fillets (deboned 3 h postmortem) were collected from a commercial deboning line and classified into normal and severe WB categories based on the prevalence and severity of diffuse hardened areas and overall fillet rigidity. Individual fillets (24 per treatment) were either ground to make patties or left intact prior to being stored for 7 days at -20P > 0.05) in the sensory texture attributes of juiciness, cohesiveness of mass, bolus size, fibrous, or rate of breakdown were observed, classified normal and WB samples. However, the springiness and hardness values of intact WB fillets were greater than those of normal fillets (P < 0.05). Springiness and chewiness values of WB patties were lower (P < 0.05) than those of normal patties. No differences (P > 0.05) in shear force were observed between normal and WB samples for either intact fillets or patties. Results demonstrate that the WB condition negatively influences the sensory texture quality of intact chicken breast fillets. However, the undesirable effects of the WB condition on cooked meat texture can be minimized in a ground product.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c1a7b1728cec3fa248950a53dca16e4Test
https://europepmc.org/articles/PMC6285881Test/

المؤلفون: D. Chatterjee, Niranjan Das, N. Hazari

المصدر: Procedia Engineering. 55:51-57

مصطلحات موضوعية: Nickel base superalloy, Materials science, Scanning electron microscope, Alloy, Metallurgy, General Medicine, Electron microprobe, engineering.material, Microstructure, Directionally solidified, Ruthenium, Superalloy, Stress (mechanics), Creep, Volume fraction, Rafting, engineering, Creep properties, Engineering(all)

الوصف: The effect of Ru addition on the microstructure, creep and rupture properties of the directionally solidified (DS) Ni based superalloy, DMD4 has been evaluated. The microstructural characterization of the alloys has been carried out using scanning electron microscopy and electron microprobe analysis. The morphology of γ′ precipitates was more cuboidal in the Ru-bearing superalloy as compared to the Ru-free superalloy. Further, Ru addition was found to increase the volume fraction of γ′ precipitates from 51% to 54% and decrease the width of the γ channels from 90 nm to 76 nm. Creep and rupture properties, evaluated at stress/temperature combinations ranging between 90-500 MPa/850-1100 °C, showed significant improvement in rupture life of the Ru containing superalloy over that of the Ru free alloy, at all combinations of stress and temperature. Such enhancement in the rupture life can be attributed to the formation of a well elongated rafted structure and the inherent higher volume fraction γ′ precipitates in the Ru-containing alloy. Larson-Miller plots derived from the creep tests suggest that addition of Ru enhanced the temperature capability of the alloy by about 11 °C for 100 hrs life at 140 MPa.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a3e609fb59dfb917a2210302f720d142Test

المؤلفون: Hansjuerg Alder, M. D. Brown, B. Kalman, M. R. Voehl, S. Li, John J. O'Connor, D. Chatterjee

المصدر: Acta Neurologica Scandinavica. 99:16-25

مصطلحات موضوعية: Adult, Male, Mitochondrial DNA, Multiple Sclerosis, Biology, medicine.disease_cause, DNA, Mitochondrial, White People, Haplogroup, Optic Atrophies, Hereditary, medicine, Humans, Mass Screening, Point Mutation, Aged, Genetics, Mutation, Point mutation, Haplotype, Sequence Analysis, DNA, General Medicine, Middle Aged, Restriction Site Polymorphism, Restriction site, Haplotypes, Neurology, Female, Neurology (clinical), Restriction fragment length polymorphism, Polymorphism, Restriction Fragment Length

الوصف: We report the first large-scale screening of mitochondrial (mt) DNA in 77 Caucasian patients with relapsing-remitting or secondary progressive form of multiple sclerosis (MS) and in 84 Caucasian controls by using the method of restriction site polymorphism and haplotype analysis. No pathogenic mtDNA mutation was found in association with MS. However, mtDNA haplotypes K * and J * defined by the simultaneous presence of Ddel restriction sites at nucleotides 10,394 and 14,798 of the mtDNA in haplogroups K and J showed association with MS at a P-value of 0.001. A relative increase of MS patients compared to controls either with the J * or with the K * haplotype (+10,394DdeI/+ 14,798Ddel in haplogroup J or K) also was detected (each with a P

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::62f28ffbd7b3030c53927367f40aab84Test
https://doi.org/10.1111/j.1600-0404.1999.tb00653.xTest