Cushing Syndrome, a rare condition with increased glucocorticoid production can affect renal function directly by its effect on glomerular and tubular functions or indirectly through the cardiovascular system. The aim is to report a case of Cushing Syndrome complicated by End Stage Renal Failure. The authors present symptoms, clinical course and laboratory findings of a 16-year-old girl with a diagnosis of Cushing syndrome complicated by end stage renal failure. She presented with excessive weight gain of 7-years, recurrent abdominal pain of 1-year, vomiting of 3-weeks and headache of a day duration. She had moon face, striae, buffalo hump and hypertension.
