دورية أكاديمية
Arginine methylation and ubiquitylation crosstalk controls DNA end-resection and homologous recombination repair
| العنوان: | Arginine methylation and ubiquitylation crosstalk controls DNA end-resection and homologous recombination repair |
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| المؤلفون: | Sanchez-Bailon, Maria Pilar, Choi, Soo Youn, Dufficy, Elizabeth R., Sharma, Karan, McNee, Gavin S., Gunnell, Emma, Chiang, Kelly, Sahay, Debashish, Maslen, Sarah, Stewart, Grant S., Skehel, J. Mark, Dreveny, Ingrid, Davies, Clare C. |
| بيانات النشر: | Springer Science and Business Media LLC |
| سنة النشر: | 2021 |
| المجموعة: | University of Nottingham: Repository@Nottingham |
| مصطلحات موضوعية: | General Physics and Astronomy, General Biochemistry, Genetics and Molecular Biology, General Chemistry |
| الوصف: | Cross-talk between distinct protein post-translational modifications is critical for an effective DNA damage response. Arginine methylation plays an important role in maintaining genome stability, but how this modification integrates with other enzymatic activities is largely unknown. Here, we identify the deubiquitylating enzyme USP11 as a previously uncharacterised PRMT1 substrate, and demonstrate that the methylation of USP11 promotes DNA end-resection and the repair of DNA double strand breaks (DSB) by homologous recombination (HR), an event that is independent from another USP11-HR activity, the deubiquitylation of PALB2. We also show that PRMT1 is a ubiquitylated protein that it is targeted for deubiquitylation by USP11, which regulates the ability of PRMT1 to bind to and methylate MRE11. Taken together, our findings reveal a specific role for USP11 during the early stages of DSB repair, which is mediated through its ability to regulate the activity of the PRMT1-MRE11 pathway. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | unknown |
| العلاقة: | https://nottingham-repository.worktribe.com/output/6681867Test; Nature Communications; Volume 12; Issue 1; https://nottingham-repository.worktribe.com/file/6681867/1/S41467-021-26413-6Test |
| DOI: | 10.1038/s41467-021-26413-6 |
| الإتاحة: | https://doi.org/10.1038/s41467-021-26413-6Test https://nottingham-repository.worktribe.com/file/6681867/1/S41467-021-26413-6Test https://nottingham-repository.worktribe.com/output/6681867Test |
| حقوق: | openAccess ; https://creativecommons.org/licenses/by/4.0Test/ |
| رقم الانضمام: | edsbas.58B4B90C |
| قاعدة البيانات: | BASE |
| DOI: | 10.1038/s41467-021-26413-6 |
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