دورية أكاديمية
A histopathological classification system of Tyr::NRASQ61K murine melanocytic lesions: A reproducible simplified classification
| العنوان: | A histopathological classification system of Tyr::NRASQ61K murine melanocytic lesions: A reproducible simplified classification |
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| المؤلفون: | Sohier, Pierre, Legrand, Léa, Aktary, Zackie, Grill, Christine, Delmas, Véronique, Bernex, Florence, Reyes-Gomez, Edouard, Larue, Lionel, Vergier, Béatrice |
| المصدر: | Pigment Cell and Melanoma Research, 31 (3), 423 - 431 (2018-05) |
| بيانات النشر: | Blackwell Publishing Ltd |
| سنة النشر: | 2018 |
| المجموعة: | University of Liège: ORBi (Open Repository and Bibliography) |
| مصطلحات موضوعية: | histopathology, Ink4a, melanocyte, melanoma, melanoma model, Pten, Ras, transgenic mice, β-catenin, Amino Acid Substitution, Animals, Mice, Transgenic, Monomeric GTP-Binding Proteins, Mutation, Missense, Biochemistry, Genetics and Molecular Biology (all), Oncology, Dermatology, General Biochemistry, Genetics and Molecular Biology, Life sciences, biophysics & molecular biology, Sciences du vivant, Biochimie, biophysique & biologie moléculaire |
| الوصف: | peer reviewed ; Genetically engineered mouse models offer essential opportunities to investigate the mechanisms of initiation and progression in melanoma. Here, we report a new simplified histopathology classification of mouse melanocytic lesions in Tyr::NRASQ 61K derived models, using an interactive decision tree that produces homogeneous categories. Reproducibility for this classification system was evaluated on a panel of representative cases of murine melanocytic lesions by pathologists and basic scientists. Reproducibility, measured as inter-rater agreement between evaluators using a modified Fleiss’ kappa statistic, revealed a very good agreement between observers. Should this new simplified classification be adopted, it would create a robust system of communication between researchers in the field of mouse melanoma models. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 1755-1471 1755-148X |
| العلاقة: | https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1111%2Fpcmr.12677Test; urn:issn:1755-1471; urn:issn:1755-148X; https://orbi.uliege.be/handle/2268/291202Test; info:hdl:2268/291202; https://orbi.uliege.be/bitstream/2268/291202/1/Pigment%20Cell%20Melanoma%20Res%20-%202017%20-%20Sohier%20-%20A%20histopathological%20classification%20system%20of%20Tyr%20%20NRASQ61K%20murine%20melanocytic.pdfTest; scopus-id:2-s2.0-85038850233; info:pmid:29224244 |
| DOI: | 10.1111/pcmr.12677 |
| الإتاحة: | https://doi.org/10.1111/pcmr.12677Test https://orbi.uliege.be/handle/2268/291202Test https://orbi.uliege.be/bitstream/2268/291202/1/Pigment%20Cell%20Melanoma%20Res%20-%202017%20-%20Sohier%20-%20A%20histopathological%20classification%20system%20of%20Tyr%20%20NRASQ61K%20murine%20melanocytic.pdfTest |
| حقوق: | open access ; http://purl.org/coar/access_right/c_abf2Test ; info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.B563C7DA |
| قاعدة البيانات: | BASE |
| تدمد: | 17551471 1755148X |
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| DOI: | 10.1111/pcmr.12677 |