التفاصيل البيبلوغرافية
| العنوان: |
Role of virus-encoded microRNAs in herpesvirus biology |
| المؤلفون: |
Boss, Isaac W.1, Plaisance, Karlie B.1, Renne, Rolf1 rrenne@ufl.edu |
| المصدر: |
Trends in Microbiology. Dec2009, Vol. 17 Issue 12, p544-553. 10p. |
| مصطلحات موضوعية: |
*RNA viruses, *VIRAL genetics, *GENETIC code, *HERPESVIRUSES, *NUCLEOTIDES, *GENETIC regulation, *MESSENGER RNA, *GENE silencing, *GENE targeting, *VIRAL replication |
| مستخلص: |
MicroRNAs (miRNAs) are short RNAs of about 22 nucleotides in length that post-transcriptionally regulate gene expression by binding to 3’ untranslated regions of mRNAs, thereby inducing translational silencing. Recently, more than 140 miRNAs have been identified in the genomes of herpesviruses. Deciphering their role in viral biology requires the identification of target genes, a challenging task because miRNAs require only limited complementarity. The subject of this review will be the herpesvirus miRNAs and their respective target genes that have been determined experimentally to date. These miRNAs regulate fundamental cellular processes including immunity, angiogenesis, apoptosis, and key steps in the herpesvirus life cycle, latency and the switch from latent to lytic replication. [Copyright &y& Elsevier] |
| قاعدة البيانات: |
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