دورية أكاديمية
The dual role of the X-linked FoxP3 gene in human cancers
| العنوان: | The dual role of the X-linked FoxP3 gene in human cancers |
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| المؤلفون: | Redpath, Margaret, Xu, Bin, van Kempen, Leon C, Spatz, Alan |
| المصدر: | Redpath , M , Xu , B , van Kempen , L C & Spatz , A 2011 , ' The dual role of the X-linked FoxP3 gene in human cancers ' , Molecular oncology , vol. 5 , no. 2 , pp. 156-63 . https://doi.org/10.1016/j.molonc.2011.03.001Test |
| سنة النشر: | 2011 |
| المجموعة: | University of Groningen research database |
| مصطلحات موضوعية: | Animals, Forkhead Transcription Factors/genetics, Gene Expression Regulation, Neoplastic, Humans, Melanoma/genetics, Neoplasms/genetics, Skin Neoplasms/genetics |
| الوصف: | The FoxP3 (forkhead box P3) gene is an X-linked gene that is submitted to inactivation. It is an essential transcription factor in CD4(+)CD25(+)FoxP3 regulatory T cells, which are therapeutic targets in disseminated cutaneous melanoma. Moreover, FoxP3 is an important tumor suppressor gene in carcinomas and has putative cancer suppressor gene function in cutaneous melanoma as well. Therefore understanding the structure and function of the FoxP3 gene is crucial to gaining insight into the biology of melanoma to better develop immunotherapeutics and future therapeutic strategies. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| العلاقة: | https://research.rug.nl/en/publications/f671c2ec-58c5-4913-9021-c67f2abe0058Test |
| DOI: | 10.1016/j.molonc.2011.03.001 |
| الإتاحة: | https://doi.org/10.1016/j.molonc.2011.03.001Test https://hdl.handle.net/11370/f671c2ec-58c5-4913-9021-c67f2abe0058Test https://research.rug.nl/en/publications/f671c2ec-58c5-4913-9021-c67f2abe0058Test https://pure.rug.nl/ws/files/121822760/The_dual_role_of_the_X_linked_FoxP3_gene_in_human_cancers.pdfTest |
| حقوق: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.21DA3089 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1016/j.molonc.2011.03.001 |
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