التفاصيل البيبلوغرافية
| العنوان: |
Epstein-Barr Virus Promotes Tumorigenicity and Worsens Hodgkin Lymphoma Prognosis by Activating JAK/STAT and NF-?B Signaling Pathways. |
| المؤلفون: |
Alabiad, Mohamed Ali1 maabyad@medicine.zu.edu.eg, Said, Warda M. M.2, Faraj Saad, Rema H.2, Balata, Rawda3, Mahmoud, Asmaa A.4, Metwally, Elsayed Anany5, Shalaby, Amany Mohamed6, Samy, Walaa7, Yehia, Ahmed M.8, Yahia, Amar Ibrahim Omar9,10, Alorini, Mohammed1,11, Abdelrahman, Doaa I.1 |
| المصدر: |
Iranian Journal of Medical Sciences. Feb2024, Vol. 49 Issue 2, p88-100. 13p. |
| مصطلحات موضوعية: |
*HODGKIN'S disease, *CANCER invasiveness, *NF-kappa B, *JANUS kinases, *CELLULAR signal transduction, *GENE expression, *COMPARATIVE studies, *MESSENGER RNA, *CHI-squared test, *KAPLAN-Meier estimator, *DESCRIPTIVE statistics, *EPSTEIN-Barr virus diseases, *EPIGENOMICS, *LONGITUDINAL method |
| مستخلص: |
Background: Epstein-Barr virus (EBV) is detected in 40% of patients with Hodgkin lymphoma (HL). During latency, EBV induces epigenetic alterations to the host genome and decreases the expression of pro-apoptotic proteins. The present study aimed to evaluate the expression levels of mRNA molecules and the end product of proteins for the JAK/STAT and NF-κB pathways, and their association with clinicopathological and prognostic parameters in patients with EBV-positive and -negative classical Hodgkin lymphoma (CHL). Methods: A prospective cohort study was conducted from 2017 to 2022 at the Faculty of Medicine, Zagazig University Hospital (Zagazig, Egypt). Biopsy samples of 64 patients with CHL were divided into EBV-positive and EBV-negative groups. The expression levels of mRNA molecules (JAK2, STAT1, IRF-1, PD-L1, IFN-γ, NF-κB, Bcl-xL, COX-2) and the end product of proteins (PD-L1, Bcl-xL, COX-2) were determined and compared with clinicopathological and prognostic parameters. Data were analyzed using the Chi square test and Kaplan-Meier estimate. Results: EBV-positive CHL patients were significantly associated with positive expression of mRNAs molecules (P<0.001) and the end product of proteins (P<0.001) for the JAK/STAT and NF-κB pathways, B-symptoms (P=0.022), extra-nodal involvement (P=0.017), and advanced stage of CHL (P=0.018). These patients were more susceptible to cancer progression, higher incidence of relapse (P=0.008), poor disease-free survival rate (P=0.013), poor overall survival rate (P=0.028), and higher mortality rate (P=0.015). Conclusion: Through the activation of JAK/STAT and NF-κB signaling pathways, EBV-positive CHL is associated with poor clinicopathological parameters, higher incidence of disease progression, relapse, and poor overall survival. [ABSTRACT FROM AUTHOR] |
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