التفاصيل البيبلوغرافية
| العنوان: |
Clinical genomic profiling identifies TYK2 mutation and overexpression in patients with neurofibromatosis type 1-associated malignant peripheral nerve sheath tumors. |
| المؤلفون: |
Hirbe, Angela C., Kaushal, Madhurima, Sharma, Mukesh Kumar, Dahiya, Sonika, Pekmezci, Melike, Perry, Arie, Gutmann, David H. |
| المصدر: |
Cancer (0008543X); Apr2017, Vol. 123 Issue 7, p1194-1201, 9p |
| مصطلحات موضوعية: |
GENE expression, NEUROFIBROMATOSIS 1, NEUROFIBROMATOSIS, NEUROFIBROMA, CANCER prognosis, GENETICS |
| مستخلص: |
BACKGROUND Malignant peripheral nerve sheath tumors (MPNSTs) are aggressive sarcomas that arise at an estimated frequency of 8% to 13% in individuals with neurofibromatosis type 1 (NF1). Compared with their sporadic counterparts, NF1-associated MPNSTs (NF1-MPNSTs) develop in young adults, frequently recur (approximately 50% of cases), and carry a dismal prognosis. As such, most individuals affected with NF1-MPNSTs die within 5 years of diagnosis, despite surgical resection combined with radiotherapy and chemotherapy. METHODS Clinical genomic profiling was performed using 1000 ng of DNA from 7 cases of NF1-MPNST, and bioinformatic analyses were conducted to identify genes with actionable mutations. RESULTS A total of 3 women and 4 men with NF1-MPNST were identified (median age, 38 years). Nonsynonymous mutations were discovered in 4 genes (neurofibromatosis type 1 [ NF1], ROS proto-oncogene 1 [ ROS1], tumor protein p53 [ TP53], and tyrosine kinase 2 [ TYK2]), which in addition were mutated in other MPNST cases in this sample set. Consistent with their occurrence in individuals with NF1, all tumors had at least 1 mutation in the NF1 gene. Whereas TP53 gene mutations are frequently observed in other cancers, ROS1 mutations are common in melanoma (15%-35%), another neural crest-derived malignancy. In contrast, TYK2 mutations are uncommon in other malignancies (<7%). In the current series, recurrent TYK2 mutations were identified in 2 cases of NF1-MPNST (30% of cases), whereas TYK2 protein overexpression was observed in 60% of MPNST cases using an independently generated tissue microarray, regardless of NF1 status. CONCLUSIONS Clinical genomic analysis of the current series of NF1-MPNST cases found that TYK2 is a new gene mutated in MPNST. Future work will focus on examining the utility of TYK2 expression as a biomarker and therapeutic target for these cancers. Cancer 2017;123:1194-1201. © 2016 American Cancer Society. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
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