نتائج البحث - "Activation-induced (cytidine) deaminase"

1

Pan-cancer landscape of AID-related mutations, composite mutations and its potential role in the ICI response

المؤلفون: Khê Hoang-Xuan, Karim Labreche, M. Sanson, Ahmed Idbaih, Daniele Ramazzotti, K Mokhtari, Kadir C. Akdemir, Franck Bielle, Mehdi Touat, Agusti Alentorn, Giulio Caravagna, Alex Duval, Isaias Hernández-Verdin, Matthieu Peyre

مصطلحات موضوعية: Transcriptome, Mutation, biology, Activation-induced (cytidine) deaminase, biology.protein, medicine, Cancer research, Somatic hypermutation, Cytidine deaminase, Cell cycle, medicine.disease_cause, Gene, Exome

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::844873ac95f0cfa0f0d3b4451777fa1eTest
https://doi.org/10.1101/2021.06.26.447715Test

2

DNA methylation, deamination, and translesion synthesis combine to generate footprint mutations in cancer driver genes in B-cell derived lymphomas and other cancers

المؤلفون: David Neil Cooper, Kathrin Tyryshkin, Lennard Y. Poliakov, Artem G. Lada, Youri I. Pavlov, Anna R. Panchenko, Andreu Saura, Kelvin Carrasquillo-Carrión, Igor B. Rogozin, Elena Schwartz, Abiel Roche-Lima, Vyacheslav Yurchenko

المصدر: Frontiers in Genetics
Frontiers in Genetics, Vol 12 (2021)

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::86cd524e433640ae19faa5d4ead93ff1Test

3

AID overexpression leads to aggressive murine CLL and non-Ig mutations that mirror human neoplasms

المساهمون: Molecular and structural microbiology / Microbiología Molecular y Estructural [Montevideo], Institut Pasteur de Montevideo, Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP)

المصدر: Blood
Blood, American Society of Hematology, 2021, ⟨10.1182/blood.2020008654⟩

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b968efabea27f8c61fc4f1f7fb3cd8edTest
https://hal-pasteur.archives-ouvertes.fr/pasteur-03246646Test

4

ETS1 and PAX5 transcription factors recruit AID toIghDNA

المؤلفون: Anshu Priya, Neema Negi, Anjani Kumar, Thomas Grundström, Christine Grundström

المصدر: European Journal of Immunology. 48:1687-1697

مصطلحات موضوعية: 0301 basic medicine, Genetics, Immunology, Transcription factor complex, Somatic hypermutation, Cytidine deaminase, Biology, 03 medical and health sciences, 030104 developmental biology, 0302 clinical medicine, Immunoglobulin class switching, hemic and lymphatic diseases, Activation-induced (cytidine) deaminase, biology.protein, Immunology and Allergy, Immunoglobulin heavy chain, Gene, Transcription factor, 030215 immunology

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::923fb02d3de2e1a0e8426eed1b7fc466Test
https://doi.org/10.1002/eji.201847625Test

5

UnAIDed Class Switching in Activated B-Cells Reveals Intrinsic Features of a Self-Cleaving IgH Locus

المؤلفون: Iman Dalloul, Brice Laffleur, Zeinab Dalloul, Batoul Wehbi, Florence Jouan, Baptiste Brauge, Paco Derouault, Jeanne Moreau, Sven Kracker, Alain Fischer, Anne Durandy, Sandrine Le Noir, Michel Cogné

المساهمون: Chard-Hutchinson, Xavier, Rôle de la classe des Ig / BCR dans les interactions cellulaires supportant la mémoire immune et impact immunopathologique - - Ig-MemImpact2016 - ANR-16-CE15-0019 - AAPG2016 - VALID, Contrôle de la Réponse Immune B et des Lymphoproliférations (CRIBL), Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Institut Génomique, Environnement, Immunité, Santé, Thérapeutique (GEIST), Université de Limoges (UNILIM)-Université de Limoges (UNILIM), Microenvironment, Cell Differentiation, Immunology and Cancer (MICMAC), Université de Rennes (UR)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), CHU Limoges, Imagine - Institut des maladies génétiques (IHU) (Imagine - U1163), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité), ANR-16-CE15-0019-01, Agence Nationale de la Recherche, Association pour la Recherche sur le Cancer, ANR-16-CE15-0019,Ig-MemImpact,Rôle de la classe des Ig / BCR dans les interactions cellulaires supportant la mémoire immune et impact immunopathologique(2016), Institut Génomique, Environnement, Immunité, Santé, Thérapeutique (GEIST), Université de Limoges (UNILIM)-Université de Limoges (UNILIM)-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM), Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Paris (UP)

المصدر: Frontiers in Immunology
Frontiers in Immunology, 2021, 12, ⟨10.3389/fimmu.2021.737427⟩
Frontiers in Immunology, Frontiers, 2021, 12, ⟨10.3389/fimmu.2021.737427⟩
Frontiers in Immunology, Vol 12 (2021)

مصطلحات موضوعية: DNA End-Joining Repair, [SDV]Life Sciences [q-bio], Immunology, class switch DNA recombination (CSR), AICDA, Cleavage (embryo), Lymphocyte Activation, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Cytidine deamination, Cytidine Deaminase, Activation-induced (cytidine) deaminase, Immunology and Allergy, Animals, Humans, class switch, Gene, 030304 developmental biology, Original Research, Mice, Knockout, 0303 health sciences, B-Lymphocytes, biology, B lymphocyte, DNA Breaks, Synapsis, Immunologic Deficiency Syndromes, Germinal center, RC581-607, Immunoglobulin Class Switching, Cell biology, [SDV] Life Sciences [q-bio], Disease Models, Animal, Immunoglobulin class switching, chemistry, Genetic Loci, biology.protein, Immunologic diseases. Allergy, Immunoglobulin Heavy Chains, immunoglobulin, 030217 neurology & neurosurgery, DNA

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f08d8b8fedf080228226d25a3163eda9Test
https://doi.org/10.3389/fimmu.2021.737427Test

6

Post-Transformation IGHV-IGHD-IGHJ Mutations in Chronic Lymphocytic Leukemia B Cells: Implications for Mutational Mechanisms and Impact on Clinical Course

المؤلفون: Davide Bagnara, Catherine Tang, Jennifer R. Brown, Siddha Kasar, Stacey Fernandes, Monica Colombo, Stefano Vergani, Andrea N. Mazzarello, Fabio Ghiotto, Silvia Bruno, Fortunato Morabito, Kanti R. Rai, Jonathan E. Kolitz, Jacqueline C. Barrientos, Steven L. Allen, Franco Fais, Matthew D. Scharff, Thomas MacCarthy, Nicholas Chiorazzi

المصدر: Frontiers in Oncology
Frontiers in Oncology, Vol 11 (2021)

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c62911f234efe686b96277212c3f776Test

7

Correlations in Somatic Hypermutation Between Sites in IGHV Genes Can Be Explained by Interactions Between AID and/or Polη Hotspots

المؤلفون: Artem Krantsevich, Catherine Tang, Thomas MacCarthy

المصدر: Frontiers in Immunology
Frontiers in Immunology, Vol 11 (2021)

مصطلحات موضوعية: lcsh:Immunologic diseases. Allergy, 0301 basic medicine, activation-induced deaminase, Genes, Immunoglobulin Heavy Chain, overlapping hotspots, Immunology, Immunoglobulin Variable Region, Somatic hypermutation, Complementarity determining region, DNA polymerase eta, DNA-Directed DNA Polymerase, medicine.disease_cause, computational immunology, 03 medical and health sciences, 0302 clinical medicine, Mismatch Repair Pathway, Cytidine Deaminase, Activation-induced (cytidine) deaminase, medicine, Immunology and Allergy, Humans, Gene, Original Research, Genetics, Mutation, biology, B cell receptor, food and beverages, immunoglobulin heavy chain, somatic hypermutation, 030104 developmental biology, biology.protein, Somatic Hypermutation, Immunoglobulin, lcsh:RC581-607, IGHV@, 030215 immunology

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ff80c04c955df87eff68f2b30f91071Test
https://pubmed.ncbi.nlm.nih.gov/33603748Test

8

Activation-induced cytidine deaminase localizes to G-quadruplex motifs at mutation hotspots in lymphoma

المؤلفون: Ying-Zhi Xu, Stacy Hung, Volodymyr Shponka, Piroon Jenjaroenpun, Lisa M. Rimsza, Christian Steidl, Samantha Kendrick, Stephanie D. Byrum, Thidathip Wongsurawat, Shankar Balasubramanian, David Tannahill, Elizabeth A. Chavez

المساهمون: Jenjaroenpun, Piroon [0000-0002-1555-401X], Wongsurawat, Thidathip [0000-0002-3659-2074], Kendrick, Samantha [0000-0002-0281-5815], Apollo - University of Cambridge Repository

المصدر: Nar Cancer

مصطلحات موضوعية: AcademicSubjects/SCI01140, 0301 basic medicine, Genome instability, AcademicSubjects/SCI01060, Lymphoma, AcademicSubjects/SCI00030, 32 Biomedical and Clinical Sciences, Standard Article, AcademicSubjects/SCI01180, 3101 Biochemistry and Cell Biology, medicine.disease_cause, 3105 Genetics, 03 medical and health sciences, chemistry.chemical_compound, Rare Diseases, 0302 clinical medicine, immune system diseases, hemic and lymphatic diseases, Genetics, Activation-induced (cytidine) deaminase, medicine, 2.1 Biological and endogenous factors, Gene, Cancer, 2 Aetiology, Mutation, biology, Human Genome, 3 Good Health and Well Being, Hematology, Cytidine deaminase, 3211 Oncology and Carcinogenesis, BCL6, medicine.disease, Molecular biology, 030104 developmental biology, chemistry, 3201 Cardiovascular Medicine and Haematology, FOS: Biological sciences, 030220 oncology & carcinogenesis, biology.protein, AcademicSubjects/SCI00980, DNA, 31 Biological Sciences, Biotechnology

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6efb02e835a50c408273e3b99cf8d16eTest
https://doi.org/10.1093/narcan/zcaa029Test

9

HIV Nef enhances the expression of oncogenic c-MYC and activation-induced cytidine deaminase in Burkitt lymphoma cells, promoting genomic instability

المؤلفون: Andrew J.M. Nel, Nontlantla Mdletshe, Shaheen Mowla, Karen Shires

المصدر: Infectious Agents and Cancer, Vol 15, Iss 1, Pp 1-10 (2020)

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9919042229d635eb82eaf383f744265bTest
https://hdl.handle.net/11427/33356Test

10

Activation-induced cytidine deaminase overexpression in double-hit lymphoma: potential target for novel anticancer therapy

المؤلفون: He Huang, Mingzhe Zhao, Jingcheng Zhang, Huixian Hu, Yifen Shi

المصدر: Scientific Reports
Scientific Reports, Vol 10, Iss 1, Pp 1-10 (2020)

مصطلحات موضوعية: Lipopolysaccharides, Male, 0301 basic medicine, Mutant, Genes, myc, lcsh:Medicine, Chromosomal translocation, Kaplan-Meier Estimate, Translocation, Genetic, 0302 clinical medicine, hemic and lymphatic diseases, Activation-induced (cytidine) deaminase, Molecular Targeted Therapy, lcsh:Science, Cancer, Aged, 80 and over, Regulation of gene expression, Multidisciplinary, biology, Biological techniques, Cytidine deaminase, Middle Aged, Prognosis, Neoplasm Proteins, Up-Regulation, Gene Expression Regulation, Neoplastic, Immunoglobulin Isotypes, Oncology, Enzyme Induction, Proto-Oncogene Proteins c-bcl-6, Female, Lymphoma, Large B-Cell, Diffuse, Adult, chemical and pharmacologic phenomena, Article, 03 medical and health sciences, Cytidine Deaminase, medicine, Humans, Gene, Aged, lcsh:R, medicine.disease, Immunoglobulin Class Switching, Genes, bcl-2, Lymphoma, Ki-67 Antigen, 030104 developmental biology, Immunoglobulin class switching, biology.protein, Cancer research, lcsh:Q, 030217 neurology & neurosurgery

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c25c93c339dba3a2887dd8a58b29231dTest
https://doi.org/10.1038/s41598-020-71058-yTest

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