التفاصيل البيبلوغرافية
| العنوان: |
Increased Circulating Levels of Growth Differentiation Factor 15 in Association with Metabolic Disorders in People Living with HIV Receiving Combined Antiretroviral Therapy |
| المؤلفون: |
Domingo, Pere, Mateo, María Gracia, Villarroya, Joan, Cereijo, Rubén, Torres, Ferran, Campderrós, Laura, Gallego-Escuredo, José Miguel, Gutierrez, Mª del Mar, Mur, Isabel, Corbacho, Noemí, Vidal, Francesc, Villarroya, Francesc, Girlat, Marta |
| سنة النشر: |
2022 |
| المجموعة: |
Universitat Autònoma de Barcelona: Dipòsit Digital de Documents de la UAB |
| مصطلحات موضوعية: |
GDF15, Cardiovascular risk, Framingham, D:A:D, Insulin resistance, Metabolic syndrome, HALS |
| الوصف: |
Objective: People living with HIV (PLWH) have an increased cardiovascular risk (CVR) owing to dyslipidemia, insulin resistance, metabolic syndrome, and HIV/combination antiretroviral therapy (cART)-associated lipodystrophy (HALS). Atherosclerosis and inflammation are related to growth differentiation factor-15 (GDF15). The relationship between metabolic disturbances, HALS, and CVR with GDF15 in PLWH is not known. Research design and methods: Circulating GDF15 levels in 152 PLWH (with HALS = 60, without HALS = 43, cART-naïve = 49) and 34 healthy controls were assessed in a cross-sectional study. Correlations with lipids, glucose homeostasis, fat distribution, and CVR were explored. Results: PLWH had increased circulating GDF15 levels relative to controls. The increase was the largest in cART-treated PLWH. Age, homeostatic model assessment of insulin resistance 1 (HOMA1-IR), HALS, dyslipidemia, C-reactive protein, and CVR estimated with the Framingham score correlated with GDF15 levels. The GDF15-Framingham correlation was lost after age adjustment. No correlation was found between GDF15 and the D:A:D Data Collection on Adverse Effects of Anti-HIV Drugs (D:A:D) score estimated CVR. CVR independent predictors were patient group (naïve, HALS−, and HALS+) and cumulated protease inhibitor or nucleoside reverse transcriptase inhibitor exposure. Conclusions: PLWH, especially when cART-treated, has increased GDF15 levels-this increase is associated with dyslipidemia, insulin resistance, metabolic syndrome, HALS, and inflammation-related parameters. GDF15 is unassociated with CVR when age-adjusted. |
| نوع الوثيقة: |
article in journal/newspaper |
| وصف الملف: |
application/pdf |
| اللغة: |
English |
| تدمد: |
85123110 |
| العلاقة: |
Instituto de Salud Carlos III PI14/0063; Instituto de Salud Carlos III PI14/0700; Instituto de Salud Carlos III PI016/0503; Instituto de Salud Carlos III PI17/0420; Instituto de Salud Carlos III PI17/0498; Instituto de Salud Carlos III PI20/0106; Instituto de Salud Carlos III PI20/0137; Ministerio de Sanidad y Política Social EC11-293; Ministerio de Ciencia e Innovación IJC2018-037142-I; Agència de Gestió d'Ajuts Universitaris i de Recerca 2014-SGR-250; Agència de Gestió d'Ajuts Universitaris i de Recerca 2017-SGR-948; Instituto de Salud Carlos III RD012/0017/0014; Instituto de Salud Carlos III RD12/0017/0005; Journal of clinical medicine; Vol. 11 (january 2022); https://ddd.uab.cat/record/256041Test; urn:10.3390/jcm11030549; urn:oai:ddd.uab.cat:256041; urn:pmcid:PMC8836868; urn:pmc-uid:8836868; urn:pmid:35160008; urn:oai:pubmedcentral.nih.gov:8836868; urn:oai:egreta.uab.cat:publications/2c8e9744-24bd-4e2f-86e7-548f4c8aec78; urn:scopus_id:85123110125; urn:wos_id:000759840200001 |
| الإتاحة: |
https://ddd.uab.cat/record/256041Test |
| حقوق: |
open access ; Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original. ; https://creativecommons.org/licenses/by/4.0Test/ |
| رقم الانضمام: |
edsbas.3E54FCC7 |
| قاعدة البيانات: |
BASE |
