دورية أكاديمية
Multimarker approach including CRP, sST2 and GDF‐15 for prognostic stratification in stable heart failure
| العنوان: | Multimarker approach including CRP, sST2 and GDF‐15 for prognostic stratification in stable heart failure |
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| المؤلفون: | Kuster, Nils, Huet, Fabien, Dupuy, Anne‐marie, Akodad, Mariama, Battistella, Pascal, Agullo, Audrey, Leclercq, Florence, Kalmanovich, Eran, Meilhac, Alexandra, Aguilhon, Sylvain, Cristol, Jean-Paul, Roubille, François |
| المساهمون: | Physiologie & médecine expérimentale du Cœur et des Muscles U 1046 (PhyMedExp), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), Centre Hospitalier Régional Universitaire Montpellier (CHRU Montpellier), Neuropsychiatrie : recherche épidémiologique et clinique (PSNREC), Université Montpellier 1 (UM1)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM), Institut de Génomique Fonctionnelle (IGF) |
| المصدر: | EISSN: 2055-5822 ; ESC Heart Failure ; https://hal.science/hal-02897434Test ; ESC Heart Failure, In press, 7 (5), pp.2230-2239. ⟨10.1002/ehf2.12680⟩ |
| بيانات النشر: | HAL CCSD Wiley |
| سنة النشر: | 2020 |
| المجموعة: | Université de Montpellier: HAL |
| مصطلحات موضوعية: | Heart failure, Prognosis, Biomarkers, sST2, C-reactive protein, GDF-15, NT-proBNP, Hs-troponin, [SDV.MHEP.CSC]Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular system |
| الوصف: | International audience ; Aims Inflammation and cardiac remodelling are common and synergistic pathways in heart failure (HF). Emerging biomarkers such as soluble suppression of tumorigenicity 2 (sST2) and growth differentiation factor-15 (GDF-15), which are linked to inflammation and fibrosis process, have been proposed as prognosis factors. However, their potential additive values remain poorly investigated. Methods and results Here, we aimed at evaluating inflammatory and remodelling biomarkers to predict both short-term and long-term mortality in a population with chronic HF in comparison with other classical clinical or biological markers (i.e. N terminal pro brain natriuretic peptide, hs-cTnT, C-reactive protein) alone or using meta-analysis global group in chronic HF risk score in a cohort of 182 patients followed during 80 months (interquartile range: 12.3-90.0). Proportional hazard assumption does not hold for sST2 and C-reactive protein, and follow-up was split into short term (less than 1 year), midterm (between 1 and 5 years), and long term (after 5 years). In univariate analysis, C-reactive protein and sST2 were predictive of short-term mortality but not of middle term and long term whereas GDF-15 was predictive of short and mid-term but not of long-term mortality. In a multivariate model after adjustment for meta-analysis global group in chronic HF score including the three markers, only sST2 was predictive of short-term mortality (P = 0.0225), and only GDF-15 was predictive of middle term mortality (P = 0.0375). None of the markers was predictive of long-term mortality. Conclusions Our results demonstrate that both sST2 and GDF-15 significantly improve the prognosis evaluation of HF patients and suggest that the value of GDF-15 is more sustained overtime and could predict middle term events. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | info:eu-repo/semantics/altIdentifier/pmid/32649062; hal-02897434; https://hal.science/hal-02897434Test; https://hal.science/hal-02897434/documentTest; https://hal.science/hal-02897434/file/Kuster%20et%20al%20-%202020.pdfTest; PUBMED: 32649062; PUBMEDCENTRAL: PMC7524044; WOS: 000546706400001 |
| DOI: | 10.1002/ehf2.12680 |
| الإتاحة: | https://doi.org/10.1002/ehf2.12680Test https://hal.science/hal-02897434Test https://hal.science/hal-02897434/documentTest https://hal.science/hal-02897434/file/Kuster%20et%20al%20-%202020.pdfTest |
| حقوق: | info:eu-repo/semantics/OpenAccess |
| رقم الانضمام: | edsbas.7098BB1D |
| قاعدة البيانات: | BASE |
| DOI: | 10.1002/ehf2.12680 |
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