المؤلفون: Ying-Jian Liang, Yong-Kang Diao, Zheng-Liang Chen, Han Wu, Xin-Fei Xu, Li-Yang Sun, Ya-Hao Zhou, Jian-Hong Zhong, Lan-Qing Yao, Ting-Hao Chen, Tian Yang, Hong Wang, Jia-Le Pu, Dong-Sheng Huang, Wan Yee Lau, Feng Shen, Timothy M. Pawlik, Zhi-Yu Chen

المصدر: European Journal of Surgical Oncology. 48:1078-1086

مصطلحات موضوعية: medicine.medical_specialty, Carcinoma, Hepatocellular, Cirrhosis, medicine.medical_treatment, Splenectomy, Esophageal and Gastric Varices, Gastroenterology, Internal medicine, Hypertension, Portal, medicine, Hepatectomy, Humans, Propensity Score, Retrospective Studies, business.industry, Mortality rate, Liver Neoplasms, General Medicine, medicine.disease, Treatment Outcome, Oncology, Hepatocellular carcinoma, Cohort, Propensity score matching, Portal hypertension, Surgery, Gastrointestinal Hemorrhage, business

الوصف: Purpose Portal hypertension due to cirrhosis is common among patients with hepatocellular carcinoma (HCC). This study aimed to compare the outcomes of partial hepatectomy in patients with HCC and clinically significant portal hypertension (CSPH) with or without concurrent splenectomy and esophagogastric devascularization (CSED). Patients and methods From a multicenter database, patients with HCC and CSPH who underwent curative-intent hepatectomy were identified. Postoperative morbidity and mortality, and long-term overall survival (OS) were compared in patients with and without CSED before and after propensity score matching (PSM). Results Of the 358 enrolled patients, 86 patients underwent CSED. Before PSM, the postoperative 30-day morbidity and mortality rates were comparable between the CSED and non-CSED group (both P > 0.05). Using PSM, 81 pairs of patients were created. In the PSM cohort, the 5-year OS rate of the CSED group were significantly better than the non-CSED group (52.9%vs.36.5%, P=0.046). The former group had a significantly lower rate of variceal bleeding on follow-up (7.4%vs.21.7%, P=0.014). On multivariate analysis, CSED was associated with significantly better OS (HR: 0.39, P Conclusion Hepatectomy and CSED can safely be performed in selected patients with HCC and CSPH, which could improve postoperative prognosis by preventing variceal bleeding, and prolonging long-term survival.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d791713facf7728aac45c0df73e1c3d0Test
https://doi.org/10.1016/j.ejso.2021.11.118Test

المؤلفون: Yong-Kang Diao, Cheng-Wu Zhang, Wan Yee Lau, Ying-Jian Liang, Zheng-Liang Chen, Han Wu, Meng-Chao Wu, Yongyi Zeng, Yao-Ming Zhang, Hong Wang, Wei-Min Gu, Tian Yang, Feng Shen, Ting-Hao Chen, Lei Liang, Jie Li, Ya-Hao Zhou, Wan-Guang Zhang, Chao Li

المصدر: Cancer Management and Research. 12:5607-5618

مصطلحات موضوعية: 0301 basic medicine, medicine.medical_specialty, business.industry, medicine.medical_treatment, Retrospective cohort study, medicine.disease, Gastroenterology, 03 medical and health sciences, 030104 developmental biology, 0302 clinical medicine, Oncology, 030220 oncology & carcinogenesis, Internal medicine, Hepatocellular carcinoma, Cohort, Life expectancy, Overall survival, medicine, Multiple tumors, Hepatectomy, business, Major hepatectomy

الوصف: Background With an increase in life expectancy and improvement of surgical safety, more elderly patients with hepatocellular carcinoma (HCC), even with large tumors, are now considered for hepatectomy. This study aimed to clarify the impact of age on short- and long-term outcomes after major hepatectomy (≥3 segments) for large HCC (≥5 cm). Patients and methods Using a multicenter database, patients who underwent curative-intent major hepatectomy for large HCC between 2006 and 2016 were identified. Postoperative morbidity and mortality, overall survival (OS) and recurrence-free survival (RFS) were compared between the elderly (≥65 years) and younger ( Results Of 830 patients, 92 (11.1%) and 738 (88.9%) were elderly and younger patients, respectively. There were no significant differences in postoperative 30-day mortality and morbidity between the two groups (5.4% vs 2.6% and 43.5% vs 38.3%, both P>0.05). The 5-year OS and RFS rates in elderly patients were also comparable to younger patients (35.0% vs 33.2% and 20.0% vs 20.8%, both P>0.05). In the entire cohort, multivariable Cox-regression analyses identified that old age was not independently associated with OS and RFS. However, in the elderly cohort, preoperative alpha-fetoprotein level >400 μg/L, multiple tumors, macrovascular invasion and microvascular invasion were independently associated with decreased OS and RFS. Conclusion Carefully selected elderly patients benefited from major hepatectomy for large HCC as much as younger patients, and their long-term prognosis was determined by preoperative alpha-fetoprotein level, tumor number and presence of macro- or micro-vascular invasion.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::ce1899ff2655e6f95cb31a5514abc3eaTest
https://doi.org/10.2147/cmar.s258150Test

المؤلفون: Zhenhui Lu, Chang Liu, Feng Xia, Rongshou Zheng, Ying-Jian Liang, Yijun Yang, Wenling Wang, Rui Mao, Zhiwen Luo, Suxia Luo, Shida Yan, Minshan Chen, Jianqiang Cai, Xiaoying Wang, Zhiyu Li, Qinggang Hu, Jian Zhou, Dong Yan, Jing Tan, Yi Ba, Jianjun Zhao, Xuewen Zhang, Xun Li, Yujun Xie, Xiaofeng Zhu, Bo Chen, Bixiang Zhang, Qichen Chen, Feng Zhang, Aimin Yue, Dianrong Xiu, Xu Che, Hong Zhao, Muxing Li, Yajin Chen, Liming Wang, Jianguo Zhou, Yubao Zhang, Feng Shen, Yamin Zhang, Yue Han, Qingdong Li, Aiping Zhou, Duo Li, Yanqiao Zhang, Tao Peng, Mingyan He, Xuejun Zhang, Xiaowei Dang, Xueli Bai, Xinyu Bi, Caifeng Gong, Wenqiang Wei, Tingbo Liang, Ning Li, Zusen Wang, Yilei Mao, Zhen Huang, Tianqiang Song, Ping Yue, Xiao Chen, Rui Zhang, Lianxin Liu, Changzhen Shang, Yuan Tang, Yong Zeng, Xiujun Cai, Po Yang, Yefan Zhang, Bin Liu, Yongkun Sun, Jing Jin

المصدر: HPB : The Official Journal of the International Hepato Pancreato Biliary Association

مصطلحات موضوعية: medicine.medical_specialty, Carcinoma, Hepatocellular, medicine.medical_treatment, MEDLINE, Computer-assisted web interviewing, Targeted therapy, Surveys and Questionnaires, Pandemic, Medicine, Humans, Chemoembolization, Therapeutic, Transcatheter arterial chemoembolization, Pandemics, Response rate (survey), Hepatology, business.industry, SARS-CoV-2, Liver Neoplasms, Gastroenterology, COVID-19, Workload, medicine.disease, Hepatocellular carcinoma, Emergency medicine, Original Article, business

الوصف: Background This study aimed to investigate the work status of clinicians in China and their management strategy alteration for patients with hepatocellular carcinoma (HCC) during the COVID-19 pandemic. Methods A nationwide online questionnaire survey was conducted in 42 class-A tertiary hospitals across China. Experienced clinicians of HCC-related specialties responded with their work status and management suggestions for HCC patients during the pandemic. Results 716 doctors responded effectively with a response rate of 60.1%, and 664 were included in the final analysis. Overall, 51.4% (341/664) of clinicians reported more than a 60% reduction of the regular workload and surgeons declared the highest proportion of workload reduction. 92.5% (614/664) of the respondents have been using online medical consultation to substitute for the “face-to-face” visits. Adaptive adjustment for the treatment strategy for HCC was made, including the recommendations of noninvasive and minimally invasive treatments such as transcatheter arterial chemoembolization for early and intermediate stage. Targeted therapy has been the mainstay for advanced stage and also as a bridge therapy for resectable HCC. Discussion During the COVID-19 pandemic, online medical consultation is recommended to avoid social contact. Targeted therapy as a bridge therapy is recommended for resectable HCC considering the possibility of delayed surgery.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ba2b10994b3943cdaa5b2ce4928ac55Test
http://europepmc.org/articles/PMC8312214Test

المؤلفون: Hang-Dong Jia, Lei Liang, Chao Li, Han Wu, Hong Wang, Ying-Jian Liang, Ya-Hao Zhou, Wei-Min Gu, Xin-Ping Fan, Wan-Guang Zhang, Ting-Hao Chen, Zhi-Yu Chen, Jian-Hong Zhong, Wan Yee Lau, Timothy M. Pawlik, Yong-Kang Diao, Qiu-Ran Xu, Feng Shen, Cheng-Wu Zhang, Dong-Sheng Huang, Tian Yang

المصدر: Frontiers in Oncology, Vol 11 (2021)

مصطلحات موضوعية: hepatitis C virus, Cancer Research, medicine.medical_specialty, medicine.medical_treatment, Hepatitis C virus, overall survival, medicine.disease_cause, Gastroenterology, Virus, 03 medical and health sciences, 0302 clinical medicine, hepatectomy, Internal medicine, medicine, recurrence-free survival, neoplasms, RC254-282, Hepatitis B virus, business.industry, virus diseases, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, hepatocellular carcinoma, medicine.disease, digestive system diseases, Oncology, 030220 oncology & carcinogenesis, Hepatocellular carcinoma, Propensity score matching, Cohort, 030211 gastroenterology & hepatology, Observational study, Hepatectomy, business, hepatitis B virus

الوصف: BackgroundHepatocellular carcinoma (HCC) is one of the most serious consequences of chronic hepatitis B virus (HBV) or hepatitis C virus (HCV) infection. This study sought to investigate long-term outcomes after liver resection for HCC among patients with HBV/HCV co-infection (HBV/HCV-HCC) compared with patients with HBV infection (HBV-HCC).MethodsPatients who underwent curative-intent liver resection for HCC were identified from a multicenter Chinese database. Using propensity score matching (PSM), patients with HBV/HCV-HCC were matched one-to-one to patients with HBV-HCC. Overall survival (OS) and recurrence-free survival (RFS) were compared between the two groups before and after PSM.ResultsAmong 2,467 patients identified, 93 (3.8%) and 2,374 (96.2%) patients had HBV/HCV-HCC and HBV-HCC, respectively. Compared with patients with HBV-HCC, patients with HBV/HCV-HCC were older, have poorer liver-related characteristics but better tumor-related characteristics. PSM created 88 pairs of patients with comparable liver- and tumor-related characteristics (all P > 0.2). In the PSM cohort, the 3- and 5-year RFS rates in patients with HBV/HCV-HCC were 48.3% and 38.9%, which were significantly poorer than patients with HBV-HCC (61.8% and 49.2%, P = 0.037). Meanwhile, the 3- and 5-year OS rates in patients with HBV/HCV-HCC were also poorer than patients with HBV-HCC (65.4% and 51.1% vs. 73.7% and 63.0%), with a difference close to be significant between them (P = 0.081).ConclusionComparing to patients with HBV-HCC, liver resection resulted in relatively poorer long-term surgical outcomes in patients with HBV/HCV-HCC.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::124582916bd1672489cd8faf1a7c9584Test
https://www.frontiersin.org/articles/10.3389/fonc.2021.700228/fullTest

المؤلفون: Tian Yang, Han Wu, Ting-Hao Chen, Chao Li, Feng Shen, Yongyi Zeng, Wan Yee Lau, Cheng-Wu Zhang, Ya-Hao Zhou, Ju-Dong Li, Yong-Kang Diao, Lei Liang, Wei-Min Gu, Yao-Ming Zhang, Ying-Jian Liang, Cheng-Hao Shao, Hong Wang, Yu Wang, Ming-Da Wang, Jie Li, Li-Yang Sun

المصدر: American journal of surgery. 221(5)

مصطلحات موضوعية: Male, medicine.medical_specialty, Blood transfusion, Carcinoma, Hepatocellular, Hepatic resection, medicine.medical_treatment, Nutritional Status, 030230 surgery, Logistic regression, Gastroenterology, 03 medical and health sciences, 0302 clinical medicine, Predictive Value of Tests, Internal medicine, Medicine, Hepatectomy, Humans, Prealbumin, biology, business.industry, Liver Neoplasms, Albumin, nutritional and metabolic diseases, General Medicine, Middle Aged, medicine.disease, Hepatitis B, Transthyretin, Hepatocellular carcinoma, Multivariate Analysis, Preoperative Period, biology.protein, 030211 gastroenterology & hepatology, Surgery, Female, Liver function, business, Biomarkers

الوصف: Prealbumin is a more sensitive serum biomarker in reflecting liver function and nutritional status than albumin, because of its shorter half-life and its characteristics that could hardly be affected by supplemental venous infusion of albumin or blood transfusion. This study aimed to identify whether preoperative prealbumin level was associated with postoperative mortality and morbidity after hepatic resection for patients with hepatocellular carcinoma (HCC).From a Chinese multicenter database, patients who underwent hepatic resection for HCC were divided into the low and normal prealbumin groups by using 17 mg/dL as the cut-off level for serum prealbumin taken within a week before surgery. Using univariable and multivariable logistic regression analyses, independent predictors associated with postoperative 30-day and 90-day mortality, 30-day overall and major morbidity, and postoperative hepatic insufficiency were identified.Among 1356 patients, 409 (30.2%) had a low preoperative prealbumin level. Postoperative 30-day and 90-day mortality, and 30-day overall and major morbidity in the low prealbumin group were significantly higher than the normal prealbumin group (2.9% vs. 0.5%, 5.1% vs. 1.5%, 35.7% vs. 18.4%, and 14.4% vs. 6.5%, respectively, all P 0.001). Multivariable analyses identified that preoperative prealbumin level, but not albumin level, was independently associated with postoperative 30-day mortality (OR: 3.486, 95% CI: 1.184-10.265), 90-day mortality (2.504, 1.219-5.145), 30-day overall morbidity (1.727, 1.302-2.292), 30-day major morbidity (1.770, 1.155-2.711) and postoperative hepatic insufficiency (1.967, 1.119-3.427).Preoperative prealbumin level could be used to predict postoperative morbidity and mortality for patients treated with hepatic resection for HCC.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b3ea3117b10012a97a6b2e4ac29b65ffTest
https://pubmed.ncbi.nlm.nih.gov/32951853Test

المؤلفون: Jinlu Wang, Jinmei Li, Xingda Li, Ying-Jian Liang, Xiaona Zhang

المصدر: Techniques in coloproctology. 24(8)

مصطلحات موضوعية: medicine.medical_specialty, Endoscopic Mucosal Resection, business.industry, Rectal Neoplasms, Submucosal tumor, Magnetic Phenomena, Gastroenterology, Endoscopic mucosal resection, Endoscopic submucosal dissection, Colorectal surgery, medicine, Humans, Surgery, Radiology, business, Abdominal surgery

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::35f67ea3db3e96219592f678af82bd63Test
https://pubmed.ncbi.nlm.nih.gov/32303932Test

المؤلفون: Ting-Hao Chen, Yong-Kang Diao, Tian Yang, Ying-Jian Liang, Wei-Min Gu, Jie Li, Ya-Hao Zhou, Hong Wang, Wan Yee Lau, Xin-Ping Fan, Jun-Wei Liu

المصدر: Annals of Hepato-Biliary-Pancreatic Surgery. 25:S241-S241

مصطلحات موضوعية: Hepatitis B virus, medicine.medical_specialty, Cirrhosis, business.industry, Incidence (epidemiology), Hazard ratio, Perioperative, medicine.disease, medicine.disease_cause, Gastroenterology, humanities, Internal medicine, Hepatocellular carcinoma, Medicine, Portal hypertension, General Materials Science, Young adult, business

الوصف: Introduction Hepatocellular carcinoma (HCC) is common among adolescents and young adults (AYAs) with chronic hepatitis B virus (HBV) infection in areas with endemic HBV. We sought to characterize clinical features and long-term oncologic outcomes among AYAs versus older adults (OAs) who underwent liver resection for HCC. Methods Patients undergoing curative-intent liver resection for HCC were identified using a Chinese multicenter database; patients were categorized as AYA (aged 13-39 years) versus OA (aged ≥ 40 years). Patient clinical features, perioperative outcomes, overall survival (OS) and time-to-recurrence (TTR) were evaluated and compared. Multivariable Cox-regression analyses were performed to identify the impact of age relative to the risk factors associated with OS and TTR. Results Among 1,952 patients with HCC who underwent resection, 354 (22.2%) were AYAs. AYAs were less likely to have cirrhosis or portal hypertension yet were likely to have advanced tumor pathological characteristics than OAs. Although major hepatectomy was more often performed in the AYA group, postoperative morbidity and mortality were comparable between the AYA and OA groups. Compared with OAs, the AYAs had a comparable OS (median: 88.8 vs. 93.2 months, p = 0.305) but a decreased TTR (median: 35.6 vs. 50.7 months, p = 0.029). After adjustment for other confounding factors on multivariable analyses, young age (< 40 years) was independently associated with poorer TTR (hazard ratio: 1.35, 95% confidence interval: 1.08-1.69, p = 0.009) but not OS (p = 0.15). Conclusions Compared with OAs, AYAs had a higher incidence of recurrence following liver resection among Chinese patients with HCC, suggesting that enhanced surveillance for postoperative recurrence may be required among.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::12ac3ccbf2d2e3ee60f501776f98c809Test
https://doi.org/10.14701/ahbps.ep-40Test

المؤلفون: Ying-Jian Liang, Hong Wang, Wan Yee Lau, Lei Liang, Chao Li, Hang-Dong Jia, Han Wu, Qiu-Ran Xu, Ya-Hao Zhou, Dong-Sheng Huang, Wei-Min Gu, Cheng-Wu Zhang, Xin-Ping Fan, Timothy M. Pawlik, Yong-Kang Diao, Tian Yang, Feng Shen

المصدر: Annals of Hepato-Biliary-Pancreatic Surgery. 25:S245-S245

مصطلحات موضوعية: Hepatitis B virus, medicine.medical_specialty, business.industry, Hepatitis C virus, virus diseases, medicine.disease_cause, medicine.disease, Gastroenterology, digestive system diseases, Virus, Internal medicine, Hepatocellular carcinoma, Propensity score matching, Cohort, medicine, General Materials Science, Observational study, In patient, business, neoplasms

الوصف: Introduction Hepatocellular carcinoma (HCC) is one of the most serious consequences of chronic hepatitis B virus (HBV) or hepatitis C virus (HCV) infection. This study sought to investigate long-term outcomes after liver resection for HCC among patients with HBV/HCV co-infection (HBV/HCV-HCC) compared with patients with HBV infection (HBV-HCC). Methods Patients who underwent curative-intent liver resection for HCC were identified from a multicenter Chinese database. Using propensity score matching (PSM), patients with HBV/HCV-HCC were matched one-to-one to patients with HBV-HCC. Overall survival (OS) and recurrence-free survival (RFS) were compared between the two groups before and after PSM. Results Among 2,467 patients identified, 93 (3.8%) and 2,374 (96.2%) patients had HBV/HCV-HCC and HBV-HCC, respectively. Compared with patients with HBV-HCC, patients with HBV/HCV-HCC were older, have poorer liver-related characteristics but better tumor-related characteristics. PSM created 88 pairs of patients with comparable liver- and tumor-related characteristics (all p > 0.2). In the PSM cohort, the 3- and 5-year RFS rates in patients with HBV/HCV-HCC were 48.3% and 38.9%, which were significantly poorer than patients with HBV-HCC (61.8% and 49.2%, p = 0.037). Meanwhile, the 3- and 5-year OS rates in patients with HBV/HCV-HCC were also poorer than patients with HBV-HCC (65.4% and 51.1% vs. 73.7% and 63.0%), with a difference close to be significant between them (p = 0.081). Conclusions Comparing to patients with HBV-HCC, liver resection resulted in relatively poorer long-term surgical outcomes in patients with HBV/HCV-HCC.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::d85e68fdac3ab8b94c6aaf0df75e3c5bTest
https://doi.org/10.14701/ahbps.ep-44Test

المؤلفون: Chengcheng Zhang, Y.-K. Diao, Hong Wu, Wan-Guang Zhang, Ying-Jian Liang, Zheng-Liang Chen, Yongyi Zeng, Lei Liang, Tian Yang

المصدر: HPB. 23:S153

مصطلحات موضوعية: Oncology, medicine.medical_specialty, Hepatology, Multicenter study, Scale (ratio), business.industry, Hepatocellular carcinoma, Internal medicine, Gastroenterology, medicine, medicine.disease, business, Major hepatectomy

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::20453ec59b66b6cf6e5d1811e2ea7554Test
https://doi.org/10.1016/j.hpb.2020.11.376Test

المؤلفون: Ying-Jian Liang, Zheng-Liang Chen, Tian Yang

المصدر: HPB. 22:789

مصطلحات موضوعية: Pancreas adenocarcinoma, medicine.medical_specialty, Waiting Lists, Hepatology, business.industry, General surgery, Gastroenterology, Adenocarcinoma, Wait time, Pancreatic Neoplasms, Humans, Medicine, business, Pancreas

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7cd386d03f83d2cd36aaa1d8107ae0bfTest
https://doi.org/10.1016/j.hpb.2020.01.015Test