نتائج البحث - "Type i diabetes mellitus"

1

THE LEVEL OF INTERLEUKIN-18 IN THE ORAL FLUID IN PRIMARY SCHOOL CHILDREN WITH CHRONIC CATARRHAL GINGIVITIS AND TYPE I DIABETES MELLITUS

المؤلفون: Natalia A. Lyakhova, Iryna O. Kuz, Iryna M Tkachenko, Olga V Sheshukova, Alina I. Maksymenko

المصدر: Wiadomości Lekarskie. 74:1336-1340

مصطلحات موضوعية: medicine.medical_specialty, business.industry, medicine.medical_treatment, Type i diabetes mellitus, General Medicine, medicine.disease, Oral hygiene, Gastroenterology, Proinflammatory cytokine, Gingivitis, Cytokine, Internal medicine, Diabetes mellitus, Catarrhal gingivitis, medicine, Interleukin 18, medicine.symptom, business

الوصف: OBJECTIVE The aim: Of our research work was to study the level of proinflammatory interleukin-18 (IL-18) in the oral fluid of children with type I diabetes mellitus (DM), and to determine their periodontal status and the level of oral hygiene. PATIENTS AND METHODS Materials and methods: 82 children were examined, they were divided into groups by presence of gingivitis and diabetes mellitus. The level of interleukin-18 in oral fluid was determined by immunoassay. RESULTS Results: In patients with chronic catarrhal gingivitis and type I diabetes mellitus the level of interleukin-18 in oral fluid is the highest (70.91±7.48 pg / ml); the level of interleukin-18 in children with diabetes mellitus and healthy gums is high enough too, it is 14.87±1.11 pg / ml. Interleukin-18 is 3.41±0.25 pg / ml in healthy children with healthy gums. It is 5.74±0.27 pg / ml in somatically healthy children with chronic catarrhal gingivitis. CONCLUSION Conclusions: We indicated that an increase in the value of interleukin-18 in oral fluid is associated with the presence of diabetes mellitus in children. Moreover, this cytokine can be considered as a potential biomarker of gum inflammation in children with diabetes mellitus.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::acc4c5715372107c39266a4e8015037dTest
https://doi.org/10.36740/10.36740/wlek202106109Test

2

Glycogenic Hepatopathy as the Etiology of Abnormal Liver Chemistries in an Uncontrolled Type I Diabetic Patient

المؤلفون: Jenine Zaibaq-Krill, Abdullah S. Shaikh, Sheharyar Merwat, Shehzad Merwat, Heather L. Stevenson

المصدر: Cureus

مصطلحات موضوعية: medicine.medical_specialty, business.industry, elevated liver transaminases, abnormal liver chemistries, General Engineering, Endocrinology/Diabetes/Metabolism, Gastroenterology, adolescent diabetes, glycogenic hepatopathy, Internal medicine, medicine, Etiology, Internal Medicine, type i diabetes mellitus, Abnormal liver, Diabetic patient, business

الوصف: Non-alcoholic fatty liver disease (NAFLD) is the most common chronic liver disease in diabetics. However, it is not the sole cause of chronic liver disease in diabetics. We present a case of an 18-year-old male with poorly controlled type I diabetes mellitus who presented for evaluation of asymptomatic elevated liver chemistries. An extensive autoimmune, metabolic, and infectious workup was unrevealing. Liver biopsy was consistent with glycogenic hepatopathy without evidence of steatosis or fibrosis. Increased glycemic control led to his liver enzymes trending down. In conclusion, glycogenic hepatopathy should be considered in poorly controlled type 1 diabetics with elevated liver chemistries.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::43a942003d110098cb0956d521fa73ecTest
http://europepmc.org/articles/PMC8684885Test

3

Evaluation of α-klotho level in insulin dependent diabetes mellitus (IDDM) children

المؤلفون: Alireza Nezami, Fariba Tarhani, Ghobad Heidari

المصدر: Journal of Pediatric Endocrinology and Metabolism. 33:761-765

مصطلحات موضوعية: Male, 0301 basic medicine, medicine.medical_specialty, Endocrinology, Diabetes and Metabolism, 030209 endocrinology & metabolism, Comorbidity, Iran, Gastroenterology, Diabetic nephropathy, Pathogenesis, 03 medical and health sciences, 0302 clinical medicine, Endocrinology, Diabetes mellitus, Internal medicine, Humans, Medicine, Diabetic Nephropathies, Age of Onset, Renal Insufficiency, Chronic, Child, Klotho Proteins, Klotho, Glucuronidase, business.industry, Type i diabetes mellitus, Infant, Newborn, Infant, Soluble klotho, α klotho, medicine.disease, Cross-Sectional Studies, Diabetes Mellitus, Type 1, 030104 developmental biology, Case-Control Studies, Child, Preschool, Insulin dependent diabetes, Pediatrics, Perinatology and Child Health, Female, business, Biomarkers

الوصف: Objectives Reduced levels of α-Klotho is associated with the pathogenesis of various diseases including diabetes. In type I diabetes, decrease in Klotho leads to apoptosis of β-cells of pancreases. The aim of this study was to evaluate the levels of α-Klotho in type I diabetic pediatric patients. Methods In this cross-sectional single centered study, 46 patients presenting type I diabetes mellitus (case group) and 78 control group under the age of 12, referred to our clinic were included in our study. Serum levels of soluble Klotho were measured by sandwich ELISA in case and control groups. Statistical analysis was conducted for the data recorded via questionnaire. Results Mean age of the patients in the case and control group was 7.65 ± 3.09 and 7 ± 2.37, respectively. Type I diabetes patients had a significant reduction in the levels of serum Klotho, as compared to controls (p Conclusions This study reports a significant decrease in the serum levels of α-Klotho in type 1 diabetic patients. Low levels of Klotho can be associated with diabetic nephropathy and other comorbidities in these patients.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bfdd7d379a5ae756b2081f8d80cb2a9bTest
https://doi.org/10.1515/jpem-2019-0591Test

4

Glycogenic Hepatopathy: A Reversible Complication of Uncontrolled Diabetes Mellitus

المؤلفون: Usman Sagheer, Fizah S Chaudhary, Muhammad N. Yousaf, Sajid Ehsan, Hamid Ehsan

المصدر: Cureus

مصطلحات موضوعية: nonalcoholic fatty liver disease, medicine.medical_specialty, Diabetic ketoacidosis, 030204 cardiovascular system & hematology, Gastroenterology, 03 medical and health sciences, glycogenic hepatopathy, diabetic ketoacidosis, 0302 clinical medicine, Diabetes mellitus, Internal medicine, Nonalcoholic fatty liver disease, Internal Medicine, transaminitis, medicine, liver biopsy, Glycemic, medicine.diagnostic_test, liver dysfunction, business.industry, Endocrinology/Diabetes/Metabolism, General Engineering, medicine.disease, periodic acid-schiff staining, Liver biopsy, Vomiting, type i diabetes mellitus, Liver function, medicine.symptom, Complication, business, 030217 neurology & neurosurgery

الوصف: Glycogenic hepatopathy (GH) is a rare complication of long-standing uncontrolled type I diabetes mellitus (TIDM) resulting in liver dysfunction and hepatomegaly due to intrahepatic deposition of glycogen. Herein we present a 19-year-old male with a history of TIDM and multiple prior hospitalizations with diabetic ketoacidosis (DKA) who presented with nausea, vomiting, right upper quadrant pain, and massive hepatomegaly. Laboratory workup was consistent with DKA and revealed a greater than 10-fold increase in liver enzymes. Despite the resolution of DKA, his liver function was worsening, and further workup was indicated. Ultimately, he underwent a liver biopsy that showed swollen hepatocytes overloaded with intracytoplasmic glycogen consistent with glycogenic hepatopathy. It is an underestimated entity and physicians should have a high index of suspicion for GH in individuals presenting with liver dysfunction, hepatomegaly, and poor glycemic control in TIDM. Strict glycemic control may result in complete resolution of disease.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05c83c30b6b118caa433cd52a7ca097bTest
https://doi.org/10.7759/cureus.9323Test

5

The relationship between vitamin D level and organ‑specific autoimmune disorders in newly diagnosed type I diabetes mellitus

المؤلفون: Pinar Sisman, G. Akdere, Belgin Efe, Goknur Yorulmaz

المصدر: Bratislava Medical Journal. 119:544-549

الوصف: INTRODUCTION The purpose of our study is to determine vitamin D levels in patients with newly diagnosed type 1 DM, and assess the association of type 1 DM with organ-specific autoimmune disorders, as well as their association with vitamin D. MATERIAL AND METHODS We included a total of 160 patients, of whom 50 were newly diagnosed with type 1 DM (group I), 50 were formerly diagnosed with type 1 DM (group II), and 60 were healthy controls (group III). RESULTS The mean level of 25(OH)D was 14.6 ng/dL in group I, 12.1 ng/dL in group II, and 16.1 ng/dL in group III. In all diabetic patients, the 25(OH)D levels were lower than those of controls. The 25(OH)D median level was 11.4 ng/ml in all cases included into the study with ATD. In subjects without ATD, the latter level was 15.3 ng/ml. The difference was found to be statistically significant. CONCLUSIONS In this study, the vitamin D level was lower in (i) type 1 diabetic patients when compared with healthy subjects, (ii) all cases included to study with ATD when compared with patients without ATD, (iii) all APA-positive type 1 diabetic patients with ATD when compared with none (iv) APA-positive newly diagnosed type 1 diabetics when compared with those APA-negative (Tab. 7, Fig. 1, Ref. 30).

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::60bef26d5345491997356a3b93b45b2dTest
https://doi.org/10.4149/bll_2018_098Test

6

POLYMORPHISM OF THE CLINICAL SIGNS OF CELIAC DISEASE IN CHILDREN

المؤلفون: Iasi Pharmacy, Dana-Teodora Anton-Paduraru, Laura Mihaela Trandafir, Eugen Cirdeiu, Carmen Oltean, Doina Mihăilă

المصدر: Romanian Journal of Pediatrics, Vol 64, Iss 4, Pp 413-417 (2015)

مصطلحات موضوعية: medicine.medical_specialty, child, business.industry, nutritional and metabolic diseases, General Medicine, Disease, Gastroenterology, Pediatrics, RJ1-570, Polymorphism (computer science), Internal medicine, Medicine, type i diabetes mellitus, clinical signs, business, celiac disease

الوصف: Celiac disease (CD) is an autoimmune systemic condition caused by sensitivity to gluten in genetically predisposed patients. The clinical signs of CD are extremely diverse, ranging from the typical intestinal malabsorption syndrome (characterized by chronic diarrhea, abdominal distension and malnutrition) to atypical symptoms that may involve any system or organ: chronic constipation, increased level of liver enzymes, iron deficiency anemia, recurrent abdominal pain, neurological conditions, tooth enamel erosion. The authors report four pediatric cases diagnosed with various atypical forms of celiac disease: the form associated with recurrent abdominal pain and increased level of liver enzymes, and the form associated with chronic constipation, all accompanied by failure to thrive and one case of type I diabetes mellitus associated with celiac disease. To conclude with, pediatricians, gastroenterologists and general practitioners should be familiar with all the clinical forms of coeliac disease in order to be able to diagnose this childhood disease and thus prevent long-term complications like osteoporosis, infertility and intestinal lymphoma.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a92c0413373b73b02df5ed5ed8a1c80bTest
https://revistemedicale.amaltea.ro/Romanian_Journal_of_PEDIATRICS/Revista_Romana_de_PEDIATRIE-2015-Nr.4/EN/RJP_2015_4_EN_Art-12.pdfTest

7

Acute kidney injury caused by diabetic ketoacidosis in children with Type I diabetes mellitus

المؤلفون: Chan Jong Kim

المصدر: Endocrinology & Diabetes Research.

مصطلحات موضوعية: medicine.medical_specialty, Diabetic ketoacidosis, business.industry, Internal medicine, Type i diabetes mellitus, medicine, Acute kidney injury, medicine.disease, business, Gastroenterology

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::c437d38bc849448f02d6de6dd01cd486Test
https://doi.org/10.4172/2470-7570-c1-009Test

8

uNGAL - An early marker for kidney injury in patients with type I diabetes mellitus

المؤلفون: Yana Bocheva, Mila Boyadzhieva, S. Shefket, G. Popcheva

المصدر: Clinica Chimica Acta. 493:S294-S295

مصطلحات موضوعية: medicine.medical_specialty, business.industry, Internal medicine, Type i diabetes mellitus, Biochemistry (medical), Clinical Biochemistry, Kidney injury, Medicine, In patient, General Medicine, business, Biochemistry, Gastroenterology

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::ee61dd8b953ada3f0c081f0d8582f9c4Test
https://doi.org/10.1016/j.cca.2019.03.608Test

9

Vitamin D levels in newly diagnosed type I diabetes mellitus and relationship with organ specific autoimmune disorders

المؤلفون: Gonca Akdere, Belgin Efe, Goknur Yorulmaz

المصدر: Endocrine Abstracts.

مصطلحات موضوعية: medicine.medical_specialty, Endocrinology, business.industry, Internal medicine, Type i diabetes mellitus, Organ specific, medicine, Vitamin D and neurology, Newly diagnosed, business, Gastroenterology

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::42905e0f8aa8100e4b1df398bf753dc0Test
https://doi.org/10.1530/endoabs.49.ep418Test

10

Graft Duodenal Perforation due to Internal Hernia after Simultaneous Pancreas-Kidney Transplantation: Report of a Case

المؤلفون: Toshinori Ito, Yuichi Fumimoto, Masahiro Tanemura, Yoshihiko Hoshida, Yoshiki Sawa, Toshirou Nishida

المصدر: Case Reports in Gastroenterology, Vol 2, Iss 2, Pp 244-249 (2008)
Case Reports in Gastroenterology

الوصف: Although complications including graft thrombosis, graft pancreatitis, and rejection have been well documented after pancreas transplantation, the occurrence of graft duodenal perforation is uncommon. In this article, we report a case of graft duodenal perforation due to internal hernia after simultaneous pancreas-kidney transplantation (SPK). A patient with type I diabetes mellitus and diabetic nephropathy had undergone SPK from a cadaveric donor. One year later, she was admitted to our hospital for severe lower abdominal pain with preshock status. She was immediately examined by abdominal computed tomography and both peripancreas graft fluid accumulation and severe dilatation of the ileum were detected. On emergency operation, two punched holes located at the graft duodenal side near the suture line and an obstruction of herniated bowel behind the graft pancreas were detected. These holes were repaired and the internal hernia was reduced. However, a control of the intraabdominal infection was very difficult despite intensive treatment with antibiotics and additional abdominal drainage. Finally, a graft pancreatectomy was unavoidably required. When complications, including symptomatic intraabdominal infection, require re-laparotomy after pancreas transplantation, the therapeutic focus should be switched from salvaging the graft to the preservation of life.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1db49e0a9891e67fcb054c060e02d17bTest
http://www.karger.com/Article/FullText/136017Test

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