HbA1c variability and long-term glycemic control are linked to peripheral neuropathy in patients with type 1 diabetes
| العنوان: | HbA1c variability and long-term glycemic control are linked to peripheral neuropathy in patients with type 1 diabetes |
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| المؤلفون: | Larissa Carolina Garcia Franco da Rosa, Gil F. Salles, Marcus V. Pinto, Marco Antônio Salles Dantas de Lima, Lenita Zajdenverg, Joana Rodrigues Dantas, Melanie Rodacki, Luiz Felipe Pinto |
| المصدر: | Diabetology & Metabolic Syndrome Diabetology & Metabolic Syndrome, Vol 12, Iss 1, Pp 1-4 (2020) |
| بيانات النشر: | BioMed Central, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | medicine.medical_specialty, endocrine system diseases, Endocrinology, Diabetes and Metabolism, Coefficient of variation, Short Report, 030209 endocrinology & metabolism, Neurological examination, 030204 cardiovascular system & hematology, Gastroenterology, 03 medical and health sciences, 0302 clinical medicine, Diabetes mellitus, Internal medicine, Internal Medicine, medicine, lcsh:RC620-627, Long-term glycemic control, Glycemic, Type 1 diabetes, medicine.diagnostic_test, business.industry, Type 2 Diabetes Mellitus, nutritional and metabolic diseases, medicine.disease, Diabetic peripheral neuropathy, lcsh:Nutritional diseases. Deficiency diseases, Peripheral neuropathy, business, Retinopathy |
| الوصف: | Background HbA1c variability has been linked to retinopathy, renal disease and autonomic neuropathy in patients with type 1 diabetes mellitus (T1D) and type 2 diabetes mellitus (T2D). Although the same relationship has been demonstrated for diabetic peripheral neuropathy (DPN) in patients with T2D, data for T1D are still lacking. Methods Patients older than 17 years of age with ≥ 10 years of T1D duration and follow-up were included. All patients underwent nerve conduction studies and neurological examination. Laboratorial data was retrospectively extracted from chart review. Mean HbA1c (mHbA1c) over 10 years was calculated, as well as HbA1c variability estimated by standard deviation (HbA1c-SD) and coefficient of variation (HbA1c-CV). Results Fifty patients with T1D were included (30 females and 21 non-caucasians), with mean age and T1D duration of 25.6 ± 5.0 and 17.9 ± 6.1 years, respectively. The frequency of DPN was 24%. Higher mHbA1c (10.4 ± % vs 8.1 ± %; p Conclusions Not only long-term glycemic control, but also its variability is associated with DPN in patients with T1D. Larger studies are required to confirm this finding. |
| اللغة: | English |
| تدمد: | 1758-5996 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1fd9ff8567addebc1251bbbe5795b1adTest http://europepmc.org/articles/PMC7539505Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....1fd9ff8567addebc1251bbbe5795b1ad |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 17585996 |
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