المؤلفون: Arlette Darfeuille-Michaud, Pierre Lapaquette

المصدر: Journal of Clinical Gastroenterology. 44:S26-S29

مصطلحات موضوعية: Nod2 Signaling Adaptor Protein, Autophagy-Related Proteins, Gut flora, Bacterial Adhesion, Microbiology, Crohn Disease, Intestinal mucosa, GTP-Binding Proteins, Ileum, NOD2, Autophagy, Escherichia coli, Animals, Humans, Genetic Predisposition to Disease, ATG16L1, Innate immune system, biology, Intracellular parasite, Gastroenterology, biology.organism_classification, Immunity, Innate, Phenotype, Immunology, IRGM, Carrier Proteins, Intracellular

الوصف: Ileal lesions in Crohn's disease (CD) patients are colonized by pathogenic adherent-invasive Escherichia coli (AIEC) able to invade and to replicate within intestinal epithelial cells. Recent advances have highlighted the importance of the innate immune system and the critical relationship between the gut flora and the intestinal mucosa. Several combinations of genetic predisposing factors to CD have been described, with the most significant replicable associations including genes for intracellular receptor of bacterial cell walls (NOD2/CARD15), and for bacterial clearance and antigen processing through autophagy (ATG16L1 and IRGM). We recently reported that in IRGM and ATG16L1 deficient cells, intracellular AIEC LF82 bacteria have enhanced replication and that autophagy deficiency surprisingly did not interfere with the ability of intracellular bacteria to survive and/or replicate for any other E. coli strains tested, including non-pathogenic, environmental, commensal, or pathogenic strains involved in gastroenteritis. As autophagy is an innate defense mechanism acting as a cell-autonomous system for elimination of intracellular pathogens, these findings lead weight to the notion that intracellular bacteria including AIEC might play a role in CD pathogenesis.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f793b682107f81643ab68653d735603Test
https://doi.org/10.1097/mcg.0b013e3181dd4fa5Test

المؤلفون: Nathalie Rolhion, Pierre Lapaquette, Jerome Boudeau, Sylvie Miquel, Jennifer Raisch, Nicolas Barnich, Frederic A. Carvalho, Benoit Chassaing, Marie-Agnès Bringer, Adeline Sivignon, Patrick Di Martino

المساهمون: Microbes, Intestin, Inflammation et Susceptibilité de l'Hôte - Clermont Auvergne (M2iSH), Institut National de la Recherche Agronomique (INRA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Clermont Auvergne (UCA)-Centre de Recherche en Nutrition Humaine d'Auvergne (CRNH d'Auvergne), Georgia State University, University System of Georgia (USG), MICrobiologie de l'ALImentation au Service de la Santé (MICALIS), Institut National de la Recherche Agronomique (INRA)-AgroParisTech, MRC Centre for Molecular Bacteriology and Infection, Queen Mary University of London (QMUL), Institut National de la Santé et de la Recherche Médicale (INSERM), Microbes, Intestin, Inflammation et Susceptibilité de l'Hôte (M2iSH), Institut National de la Recherche Agronomique (INRA)-Université d'Auvergne - Clermont-Ferrand I (UdA), Centre de recherche en Biologie Cellulaire (CRBM), Université Montpellier 1 (UM1)-Université Montpellier 2 - Sciences et Techniques (UM2)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), Equipe de recherche sur les relations matrice extracellulaire-cellules (ERRMECe), Fédération INSTITUT DES MATÉRIAUX DE CERGY-PONTOISE (I-MAT), Université de Cergy Pontoise (UCP), Université Paris-Seine-Université Paris-Seine-Université de Cergy Pontoise (UCP), Université Paris-Seine-Université Paris-Seine, Institut National de la Recherche Agronomique (INRA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Clermont Auvergne [2017-2020] (UCA [2017-2020])-Centre de Recherche en Nutrition Humaine d'Auvergne (CRNH d'Auvergne), Université Montpellier 2 - Sciences et Techniques (UM2)-Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM)-Université Montpellier 1 (UM1), Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), Université d'Auvergne - Clermont-Ferrand I (UdA)-Institut National de la Recherche Agronomique (INRA)

المصدر: Gut
Gut, BMJ Publishing Group, 2014, 63 (11), pp.1681-1682
Gut, BMJ Publishing Group, 2014, 63 (11), pp.1681-1682. ⟨10.1136/gutjnl-2014-308182⟩
Gastroenterology
Gastroenterology, WB Saunders, 2014, 147 (5), pp.943-944. ⟨10.1136/gutjnl-2014-308182⟩
Gastroenterology, 2014, 147 (5), pp.943-944. ⟨10.1136/gutjnl-2014-308182⟩

مصطلحات موضوعية: Gerontology, Biomedical Research, education, History, 21st Century, Microbiology, 03 medical and health sciences, 0302 clinical medicine, Education, Professional, Ileum, Intestinal inflammation, Escherichia coli, Humans, Medicine, Escherichia coli Infections, ComputingMilieux_MISCELLANEOUS, 030304 developmental biology, 2. Zero hunger, 0303 health sciences, Hepatology, business.industry, Mentors, Gastroenterology, History, 20th Century, Inflammatory Bowel Diseases, [SDV.MP.BAC]Life Sciences [q-bio]/Microbiology and Parasitology/Bacteriology, 3. Good health, Visionary leadership, Gut microbiology, [SDV.MP]Life Sciences [q-bio]/Microbiology and Parasitology, 030211 gastroenterology & hepatology, France, business, Classics, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology

الوصف: It is with profound sadness that we note the loss, at age 59, of our dear friend and mentor Dr Arlette Darfeuille-Michaud on June 28, 2014, following a 15-month battle against cancer. Arlette was a Professor at Auvergne University, and director of an INSERM unit that investigates microbial-host interactions in intestinal inflammation, located in Clermont-Ferrand, France. Arlette advanced our understanding of intestinal diseases, and humanity in general, via pioneering research in gut microbiology, visionary leadership, energetic teaching, and exceptionally supportive mentorship.⇓ Arlette lived her early years in the tiny French village of Beyssenac (in the beautiful Correze region) where her family owned and operated a fruit orchard. Arlette earned her PhD in 1987 at Auvergne University in the lab of Dr Bernard Joly, studying Klebsiella pneumoniae strains involved in nosocomial infections and Escherichia coli pathogenesis. Arlette then joined the faculty at Auvergne University as a lecturer in 1989, and then was promoted to professor in microbiology and molecular biology in 1994. Arlette then initiated a line of experimentation that would ultimately help contribute to our understanding of the pathogenesis of inflammatory bowel disease (IBD). Briefly, working with gastroenterologist Dr Jean-Frederic Colombel and Dr Christel Neut, Arlette made the discovery, reported in Gastroenterology in 1998, that many ileal samples of Crohn's patients were colonized by a previously unappreciated class of E. coli strains. As Dr Colombel recently recalled. “Arlette called us, very excited and enthusiastic, exclaiming that she had discovered …

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d8c7705437af2e73d211099e3c840b1Test
https://hal.archives-ouvertes.fr/hal-01951066Test