Ganglion Cell Layer Thickness Change in Neovascular Age-Related Macular Degeneration Treated With Anti-VEGF Injections
| العنوان: | Ganglion Cell Layer Thickness Change in Neovascular Age-Related Macular Degeneration Treated With Anti-VEGF Injections |
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| المؤلفون: | George Sanchez, Russell Pokroy, Hetal Ray, Dimosthenis Mantopoulos, Daniel B. Roth |
| المصدر: | J Vitreoretin Dis |
| بيانات النشر: | SAGE Publications, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Anti vegf, medicine.medical_specialty, genetic structures, business.industry, Cell, Glaucoma, Macular degeneration, medicine.disease, eye diseases, Ganglion, medicine.anatomical_structure, Ophthalmology, Age related, medicine, Original Manuscripts, In patient, sense organs, business, Ganglion cell layer |
| الوصف: | Purpose: This work assesses bilateral ganglion cell layer–inner plexiform layer (GCL-IPL) thickness changes in patients with unilateral neovascular age-related macular degeneration (nAMD) treated with antivascular endothelial growth factor (anti-VEGF). Methods: In this single-center, retrospective, cohort study, the medical records of patients with unilateral nAMD treated with anti-VEGF were reviewed. The treated group included eyes with newly diagnosed nAMD that subsequently underwent treatment with intravitreal anti-VEGF injections. The control group was the fellow eye with dry AMD. Eyes receiving at least 10 intravitreal injections were included. Measurement of GCL-IPL thickness was performed at different time points using spectral domain–optical coherence tomography. Results: A total of 216 eyes of 108 patients met the inclusion criteria. The mean age ± SD was 80.1 ± 10.7 years. Eyes in the treated group underwent a mean ± SD of 20.2 ± 7.2 injections in 21.3 ± 6.8 months. At baseline, average mean ± SD of GCL-IPL thickness was 73.71 ± 8.81 µm and 73.84 ± 8.26 µm in the treated and fellow eye, respectively ( P = .795). After 10 injections the average thickness was 65.41 ± 14.08 µm and 68.77 ± 13.24 µm in the treated and fellow eye, respectively ( P = .007). The absolute decrease in thickness was significantly greater in the treated eye than the fellow eye (mean ± SD, 8.31 ± 11.19 µm vs 5.07 ± 10.83 µm, respectively; P = .002). Conclusions: GCL-IPL thickness decreased significantly in the treated group more than in the control group after 10 anti-VEGF injections. The mechanism and clinical significance of this observation warrants further study. |
| تدمد: | 2474-1272 2474-1264 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::41e1ea070060a848792a3ba575ad523fTest https://doi.org/10.1177/24741264211040346Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....41e1ea070060a848792a3ba575ad523f |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 24741272 24741264 |
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