المؤلفون: Konstantina Bampali (Department of Pathobiology of the Nervous System, Center for Brain Research Medical University Vienna Vienna Austria), Filip Koniuszewski (Department of Pathobiology of the Nervous System, Center for Brain Research Medical University Vienna Vienna Austria), Luca L. Silva (Department of Pathobiology of the Nervous System, Center for Brain Research Medical University Vienna Vienna Austria), Sabah Rehman (Department of Molecular Neurosciences, Center for Brain Research Medical University of Vienna Vienna Austria), Florian D. Vogel (Department of Pathobiology of the Nervous System, Center for Brain Research Medical University Vienna Vienna Austria), Thomas Seidel (Department of Pharmaceutical Sciences, Faculty of Life Sciences, University of Vienna), Petra Scholze (Department of Pathobiology of the Nervous System, Center for Brain Research Medical University Vienna Vienna Austria), Florian Zirpel (Department of Pathobiology of the Nervous System, Center for Brain Research Medical University Vienna Vienna Austria), Arthur Garon (Department of Pharmaceutical Sciences, Division of Pharmaceutical Chemistry University of Vienna Vienna Austria), Thierry Langer (Department of Pharmaceutical Sciences, Faculty of Life Sciences, University of Vienna), Matthäus Willeit (Department of Psychiatry and Psychotherapy Medical University of Vienna Vienna Austria), Margot Ernst (Department of Pathobiology of the Nervous System, Center for Brain Research Medical University Vienna Vienna Austria)

المصدر: British Journal of Pharmacology ; issn:0007-1188

مصطلحات موضوعية: allosteric modulation, antipsychotics, chlorpromazine, clozapine, functional inhibition, GABAA receptor

وصف الملف: application/pdf

العلاقة: hdl:11353/10.1825318; https://phaidra.univie.ac.at/o:1825318Test

الإتاحة: https://doi.org/10.1111/bph.15807Test
https://phaidra.univie.ac.at/o:1825318Test

المؤلفون: Ernst, Margot, Bampali, Konstantina, Koniuszewski, Filip, Silva, Luca L., Rehman, Sabah, Vogel, Florian D., Seidel, Thomas, Scholze, Petra, Zirpel, Florian, Garon, Arthur, Langer, Thierry, Willeit, Matthäus

مصطلحات موضوعية: allosteric modulation, antipsychotics, chlorpromazine, clozapine, functional inhibition, GABAA receptor

جغرافية الموضوع: UMW:14633, UMW:14527

وصف الملف: text/html

العلاقة: vignette : https://repositorium.meduniwien.ac.at/titlepage/urn/urn:nbn:at:at-ubmuw:3-58170/128Test; urn:nbn:at:at-ubmuw:3-58170; https://resolver.obvsg.at/urn:nbn:at:at-ubmuw:3-58170Test; local:99147049051503331; system:AC16688465

الإتاحة: https://doi.org/10.1111/bph.15807Test
https://resolver.obvsg.at/urn:nbn:at:at-ubmuw:3-58170Test

المؤلفون: Jure Fabjan, Filip Koniuszewski, Benjamin Schaar, Margot Ernst

المصدر: Frontiers in Neuroscience, Vol 14 (2021)

مصطلحات موضوعية: GABAA receptor, allosteric modulation, pyrazoloquinolinone, functional selectivity, computational docking, pharmacophore analysis, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571

وصف الملف: electronic resource

العلاقة: https://www.frontiersin.org/articles/10.3389/fnins.2020.611953/fullTest; https://doaj.org/toc/1662-453XTest

الوصول الحر: https://doaj.org/article/d0ff3f9d34644bb4978a62cdf789f04fTest

المؤلفون: Anja Santrač, Miroslav M. Savić, James M. Cook, Zubair Ahmed Khan, Jovana Aranđelović, Michael M. Poe, Aleksandar Obradovic, Bojan Batinić, Farjana Rashid, Lidija Todorović

المصدر: Journal of Alzheimer's Disease

مصطلحات موضوعية: Male, medicine.medical_specialty, Elevated plus maze, GABRA5, Hippocampus, Mice, Transgenic, Emotionality, Positive allosteric modulation, Open field, 03 medical and health sciences, Benzodiazepines, Mice, 0302 clinical medicine, Alzheimer Disease, Internal medicine, medicine, GABRA3, Animals, GABRA2, Prefrontal cortex, Maze Learning, Motor function, 030304 developmental biology, 0303 health sciences, Motivation, biology, GABAA receptor, General Neuroscience, General Medicine, Alzheimer's disease, Receptors, GABA-A, 5xFAD, Psychiatry and Mental health, Clinical Psychology, Disease Models, Animal, Endocrinology, biology.protein, α5 GABAAreceptors, Female, Geriatrics and Gerontology, Negative allosteric modulation, 030217 neurology & neurosurgery

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d6ce8de72abab82d6faa38a6af4ddcd7Test
https://vinar.vin.bg.ac.rs/handle/123456789/10072Test

المؤلفون: Ahmed S. Al-Shami, Amr Ghit, Dina Assal, Diaa Eldin E. Hussein

المصدر: Journal of Genetic Engineering & Biotechnology
Journal of Genetic Engineering and Biotechnology, Vol 19, Iss 1, Pp 1-15 (2021)

مصطلحات موضوعية: Gene isoform, medicine.drug_class, Allosteric regulation, Review, QH426-470, chemistry.chemical_compound, GABA, medicine, Genetics, Autism spectrum disorder, Neurotransmitter, Receptor, Allosteric modulation, Ion channel, Benzodiazepine, GABAAR, Epilepsy, Chemistry, GABAA receptor, Cell biology, Barbiturates, Schizophrenia, GABAergic, Alzheimer’s disease, TP248.13-248.65, Biotechnology

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f82e2c7e0be9d127307059af13a571bdTest
http://europepmc.org/articles/PMC8380214Test

المؤلفون: Jure, Fabjan, Filip, Koniuszewski, Benjamin, Schaar, Margot, Ernst

المصدر: Frontiers in Neuroscience

مصطلحات موضوعية: allosteric modulation, pyrazoloquinolinone, GABAA receptor, pharmacophore analysis, functional selectivity, computational docking, Neuroscience, Original Research

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=pmid________::39fd15931335f5eb7909f6ec1847ffd9Test
https://pubmed.ncbi.nlm.nih.gov/33519364Test

المؤلفون: Jure Fabjan, Filip Koniuszewski, Benjamin Schaar, Margot Ernst

مصطلحات موضوعية: Neuroscience, Biological Engineering, Developmental Biology, Stem Cells, Artificial Intelligence and Image Processing, Endocrinology, Radiology and Organ Imaging, Autonomic Nervous System, Cellular Nervous System, Central Nervous System, Sensory Systems, Clinical Nursing: Tertiary (Rehabilitative), Decision Making, Rehabilitation Engineering, Biomedical Engineering not elsewhere classified, Signal Processing, Neurogenetics, Image Processing, GABAA receptor, allosteric modulation, pyrazoloquinolinone, functional selectivity, computational docking, pharmacophore analysis

العلاقة: https://figshare.com/articles/dataset/Table_1_Structure-Guided_Computational_Methods_Predict_Multiple_Distinct_Binding_Modes_for_Pyrazoloquinolinones_in_GABAA_Receptors_XLSX/13579700Test

الإتاحة: https://doi.org/10.3389/fnins.2020.611953.s002Test
https://figshare.com/articles/dataset/Table_1_Structure-Guided_Computational_Methods_Predict_Multiple_Distinct_Binding_Modes_for_Pyrazoloquinolinones_in_GABAA_Receptors_XLSX/13579700Test

المؤلفون: Jure Fabjan, Filip Koniuszewski, Benjamin Schaar, Margot Ernst

مصطلحات موضوعية: Neuroscience, Biological Engineering, Developmental Biology, Stem Cells, Artificial Intelligence and Image Processing, Endocrinology, Radiology and Organ Imaging, Autonomic Nervous System, Cellular Nervous System, Central Nervous System, Sensory Systems, Clinical Nursing: Tertiary (Rehabilitative), Decision Making, Rehabilitation Engineering, Biomedical Engineering not elsewhere classified, Signal Processing, Neurogenetics, Image Processing, GABAA receptor, allosteric modulation, pyrazoloquinolinone, functional selectivity, computational docking, pharmacophore analysis

العلاقة: https://figshare.com/articles/dataset/Data_Sheet_1_Structure-Guided_Computational_Methods_Predict_Multiple_Distinct_Binding_Modes_for_Pyrazoloquinolinones_in_GABAA_Receptors_pdf/13579697Test

الإتاحة: https://doi.org/10.3389/fnins.2020.611953.s001Test
https://figshare.com/articles/dataset/Data_Sheet_1_Structure-Guided_Computational_Methods_Predict_Multiple_Distinct_Binding_Modes_for_Pyrazoloquinolinones_in_GABAA_Receptors_pdf/13579697Test

المؤلفون: Monica A. Carrasco, Gonzalo E. Yévenes, Gustavo Moraga-Cid, Cesar O. Lara, Carlos F. Burgos

المصدر: Frontiers in Pharmacology, Vol 11 (2020)
Frontiers in Pharmacology

مصطلحات موضوعية: 0301 basic medicine, pentameric ligand-gated ion channels, Mini Review, Allosteric regulation, 03 medical and health sciences, 0302 clinical medicine, medicine, Pharmacology (medical), preclinical research, Glycine receptor, Ion channel, Pharmacology, allosteric modulation, GABAA receptor, business.industry, lcsh:RM1-950, Chronic pain, analgesia, medicine.disease, drug development, Nicotinic acetylcholine receptor, 030104 developmental biology, lcsh:Therapeutics. Pharmacology, 030220 oncology & carcinogenesis, Neuropathic pain, Ligand-gated ion channel, business, chronic pain, Neuroscience

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::86cfe6f918d2d0494e4ec99ed0e9d1ffTest
https://www.frontiersin.org/article/10.3389/fphar.2020.00167/fullTest

المؤلفون: Grace Brannigan, Luis G. Cuello, Genevieve L. Evans, Argel Estrada-Mondragon, Camille M. Hénault, Kristen N. Woods, Cédric Govaerts, John E. Baenziger, Benjamin W. Elberson, Marijke Brams, Hugues Nury, D. Bertrand, Radovan Spurny, Jan Steyaert, Joseph W. Lynch, Els Pardon, Chris Ulens

المساهمون: Department of Bio-engineering Sciences, Structural Biology Brussels, Children's Hospital of Eastern Ontario Research Institute, Department of Biochemistry, Microbiology and Immunology, University of Ottawa, Laboratory for the Structure and Function of Biological Membranes, Université libre de Bruxelles (ULB), Catholic University of Leuven - Katholieke Universiteit Leuven (KU Leuven), Queensland Brain Institute, University of Queensland, Brisbane 4072, Australia, HiQscreen, Vésenaz, Structural Biology Brussels (SBB), Vrije Universiteit Brussel (VUB), Center for Computational and Integrative Biology [Camden] (CCIB), Rutgers University [Camden], Rutgers University System (Rutgers)-Rutgers University System (Rutgers), Department of Cell Physiology and Molecular Biophysics, Center for Membrane Protein Research, Institut de biologie structurale (IBS - UMR 5075 ), Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019])-Institut de Recherche Interdisciplinaire de Grenoble (IRIG), Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA), University of Ottawa [Ottawa], Université Grenoble Alpes [2016-2019] (UGA [2016-2019])-Institut de Recherche Interdisciplinaire de Grenoble (IRIG), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Centre National de la Recherche Scientifique (CNRS)

المصدر: Nature Chemical Biology, 15 (12
Nature Chemical Biology
Nature Chemical Biology, 2019, 15 (12), pp.1156-1164. ⟨10.1038/s41589-019-0369-4⟩
Nat. Chem. Biol.
Nature Chemical Biology, Nature Publishing Group, 2019, 15 (12), pp.1156-1164. ⟨10.1038/s41589-019-0369-4⟩
Nat Chem Biol

مصطلحات موضوعية: Agonist, STRUCTURAL BASIS, MECHANISM, DYNAMICS, Biochemistry & Molecular Biology, medicine.drug_class, Xenopus, CONSERVATION, Phospholipid, Ligands, Ion Channels, Article, ALLOSTERIC MODULATION, ACETYLCHOLINE-RECEPTOR, 03 medical and health sciences, chemistry.chemical_compound, M4, medicine, Animals, CRYSTAL-STRUCTURES, Molecular Biology, Glycine receptor, Ion channel, 030304 developmental biology, 0303 health sciences, Science & Technology, [SDV.BBM.BS]Life Sciences [q-bio]/Biochemistry, Molecular Biology/Structural Biology [q-bio.BM], GABAA receptor, TRANSMEMBRANE ALPHA-HELIX, 030302 biochemistry & molecular biology, Biologie moléculaire, Cell Biology, Lipids, 3. Good health, Transmembrane domain, chemistry, Membrane protein, Mutagenesis, Biophysics, Ligand-gated ion channel, Biologie cellulaire, lipids (amino acids, peptides, and proteins), Ion Channel Gating, Life Sciences & Biomedicine, X-RAY-STRUCTURE

وصف الملف: Print-Electronic; 1 full-text file(s): application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b737e5a3ca1fb17e1f23703c9ef72d8eTest
https://doi.org/10.1038/s41589-019-0369-4Test