Hypoxia inducible factor-1 alpha stabilization for regenerative therapy in traumatic brain injury
| العنوان: | Hypoxia inducible factor-1 alpha stabilization for regenerative therapy in traumatic brain injury |
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| المؤلفون: | Avtar K. Singh, Inderjit Singh, Mushfiquddin Khan, Hamza Khan |
| المصدر: | Neural Regeneration Research Neural Regeneration Research, Vol 12, Iss 5, Pp 696-701 (2017) |
| سنة النشر: | 2017 |
| مصطلحات موضوعية: | 0301 basic medicine, Traumatic brain injury, functional recovery, Ischemia, lcsh:RC346-429, traumatic brain injury, hypoxia inducible factor-1 alpha, S-nitrosoglutathione, neurorepair, Nitric oxide, S-Nitrosoglutathione, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Developmental Neuroscience, Concussion, medicine, lcsh:Neurology. Diseases of the nervous system, Neuroinflammation, Invited Review, business.industry, Hypoxia (medical), medicine.disease, 030104 developmental biology, chemistry, medicine.symptom, business, Neuroscience, 030217 neurology & neurosurgery, Peroxynitrite |
| الوصف: | Mild traumatic brain injury (TBI), also called concussion, initiates sequelae leading to motor deficits, cognitive impairments and subtly compromised neurobehaviors. While the acute phase of TBI is associated with neuroinflammation and nitroxidative burst, the chronic phase shows a lack of stimulation of the neurorepair process and regeneration. The deficiency of nitric oxide (NO), the consequent disturbed NO metabolome, and imbalanced mechanisms of S-nitrosylation are implicated in blocking the mechanisms of neurorepair processes and functional recovery in the both phases. Hypoxia inducible factor-1 alpha (HIF-1α), a master regulator of hypoxia/ischemia, stimulates the process of neurorepair and thus aids in functional recovery after brain trauma. The activity of HIF-1α is regulated by NO via the mechanism of S-nitrosylation of HIF-1α. S-nitrosylation is dynamically regulated by NO metabolites such as S-nitrosoglutathione (GSNO) and peroxynitrite. GSNO stabilizes, and peroxynitrite destabilizes HIF-1α. Exogenously administered GSNO was found not only to stabilize HIF-1α and to induce HIF-1α-dependent genes but also to stimulate the regeneration process and to aid in functional recovery in TBI animals. |
| تدمد: | 1673-5374 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c807c5236eb1446cebb55b45892995c6Test https://pubmed.ncbi.nlm.nih.gov/28616019Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....c807c5236eb1446cebb55b45892995c6 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 16735374 |
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