التفاصيل البيبلوغرافية
| العنوان: |
Cardioprotection by Citrus grandis (L.) Peel Ethanolic Extract in Alloxan-Induced Cardiotoxicity in Diabetic Rats. |
| المؤلفون: |
Najar, Imtiyaz Ahmed, Bhat, Moomin Hussain, Qadrie, Zulfqar Lateif, Amaldoss, Maria John Newton, Kushwah, Ajay Singh, Singh, Thakur Gurjeet, Kabra, Atul, Khan, Nadeem, Kumar, Manish |
| المصدر: |
BioMed Research International; 6/16/2022, p1-9, 9p |
| مصطلحات موضوعية: |
BLOOD sugar analysis, ANTIOXIDANT analysis, HEART metabolism, BIOMARKERS, BIOCHEMISTRY, DIABETIC cardiomyopathy, HYPOGLYCEMIC sulfonylureas, HETEROCYCLIC compounds, ANIMAL experimentation, INFLAMMATION, INTRAPERITONEAL injections, CREATINE kinase, ANTIOXIDANTS, RATS, ISOENZYMES, OXIDATIVE stress, FRUIT, LACTATE dehydrogenase, DESCRIPTIVE statistics, PLANT extracts, HIGH density lipoproteins, HISTOLOGY, CARDIOTONIC agents, CHOLESTEROL |
| مستخلص: |
Diabetic cardiomyopathy (DCM) pathogenesis is multifarious, and there are insufficient therapeutic options to treat DCM. The present research explored the effects of Citrus grandis peel ethanolic extract (CGPE) in alloxan-induced DCM in rats. Diabetes was triggered by intraperitoneal (i.p.) injection of alloxan (150 mg/kg) in Wistar rats (200-250 g). CGPE (100, 200, and 400 mg/kg) or glibenclamide (Glib, 10 mg/kg) were administered orally for 2 weeks. After the treatment schedule, prooxidants (thiobarbituric acid reactive substances), antioxidants (glutathione, catalase, and superoxide dismutase), and inflammatory markers (tumor necrosis factor-α) were determined in cardiac tissues. Biomarkers of cell death, viz., lactate dehydrogenase (LDH), creatine kinase MB (CK-MB) activity, glucose levels, total cholesterol (TC), and high-density lipoproteins (HDL), were assessed in the blood. Rats administered with alloxan showed a consistent increase in blood glucose level (days 7 and 14) that was lowered considerably (p < 0.001) by CGPE or Glib. Alloxan-induced increase in LDH, CK-MB, TC, and decline in HDL was attenuated (p < 0.001) in rats that were treated with CGPE or Glib. Alloxan significantly (p < 0.001) elevated oxidative stress, inflammation, and reduced antioxidants in the cardiac tissue of rats, and these pathogenic abnormalities were ameliorated (p < 0.001) by CGPE. Histopathological studies showed a decrease in morphological disruptions by alloxan in CGPE-treated rats. CGPE (400 mg/kg) significantly ameliorated biochemical parameters in comparison to the lower doses against alloxan cardiotoxicity. Citrus grandis peel extract can be an alternative in the management of DCM. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
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