دورية أكاديمية
The prognostic impact of monoclonal immune globulin and free light chain secretion in diffuse large B cell lymphoma (DLBCL)
| العنوان: | The prognostic impact of monoclonal immune globulin and free light chain secretion in diffuse large B cell lymphoma (DLBCL) |
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| المؤلفون: | Maiolo E., Alma E., Napodano C., Bellesi S., Cuccaro A., Pocino K., D'Alo' F., Iachini M., Martini M., Larocca L. M., De Stefano V., Basile U., Hohaus S. |
| المساهمون: | Maiolo, E., Alma, E., Napodano, C., Gulli, F., Bellesi, S., Cuccaro, A., Pocino, K., D'Alo', F., Iachini, M., Martini, M., Larocca, L. M., De Stefano, V., Basile, U., Hohaus, S. |
| بيانات النشر: | Taylor and Francis Ltd |
| سنة النشر: | 2019 |
| المجموعة: | Università Cattolica del Sacro Cuore: PubliCatt |
| مصطلحات موضوعية: | Diffuse large B-cell lymphoma, free light chain, monoclonal immune globulin, prognosis, Settore MED/15 - MALATTIE DEL SANGUE |
| الوصف: | We analyzed the prognostic impact of levels of free light chains (FLC) in 106 patients with DLBCL, selecting 61 patients with a monoclonal (M) protein in serum, and 45 patients without a M protein as an IPI-matched control group. Patients with a M protein had higher levels of FLC, but these were not of prognostic significance in this group. The presence of a M protein nullified associations of κ-FLC with several laboratory parameters indicating immune system activation observed in patients without a M protein. Patients without M protein and κ-FLC >50 mg/L had a significant inferior event-free survival (p =.004). The presence of M protein of an IgM type at diagnosis was a negative outcome predictor (p =.008), while a non-IgM M protein did not significantly impact on prognosis. In conclusion, the prognostic performance of the FLC assay is altered by the presence of a M protein. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | info:eu-repo/semantics/altIdentifier/pmid/31889454; info:eu-repo/semantics/altIdentifier/wos/WOS:000504956000001; volume:61; issue:5; firstpage:1133-1139; lastpage:1139; issueyear:2020; journal:LEUKEMIA & LYMPHOMA; http://hdl.handle.net/10807/152275Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85078604649 |
| DOI: | 10.1080/10428194.2019.1706731 |
| الإتاحة: | https://doi.org/10.1080/10428194.2019.1706731Test http://hdl.handle.net/10807/152275Test |
| رقم الانضمام: | edsbas.E348E819 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1080/10428194.2019.1706731 |
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