دورية أكاديمية
Predictors of mortality in subjects with progressive fibrosing interstitial lung diseases
| العنوان: | Predictors of mortality in subjects with progressive fibrosing interstitial lung diseases |
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| المؤلفون: | Brown, Kevin K., Inoue, Yoshikazu, Flaherty, Kevin R., Martinez, Fernando J., Cottin, Vincent, Bonella, Francesco, Cerri, Stefania, Danoff, Sonye K., Jouneau, Stéphane, Goeldner, Rainer-Georg, Schmidt, Martin, Stowasser, Susanne, Schlenker-Herceg, Rozsa, Wells, Athol U. |
| المساهمون: | National Jewish Health (NJH), University of Michigan Ann Arbor, University of Michigan System, Weill Cornell Medicine Cornell University, Cornell University New York, Centre de Référence des Maladies Pulmonaires Rares Hôpital Louis Pradel - HCL, Hôpital Louis Pradel CHU - HCL, Hospices Civils de Lyon (HCL)-Hospices Civils de Lyon (HCL), Ruhrlandklinik University Hospital, Azienda Ospedaleria Universitaria di Modena = University Hospital of Modena, Johns Hopkins University School of Medicine Baltimore, Institut de recherche en santé, environnement et travail (Irset), Université d'Angers (UA)-Université de Rennes (UR)-École des Hautes Études en Santé Publique EHESP (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), École des Hautes Études en Santé Publique EHESP (EHESP), Boehringer Ingelheim Pharma GmbH & Co. KG, Imperial College London, Royal Brompton and Harefield NHS Foundation Trust, Boehringer Ingelheim International GmbHBoehringer Ingelheim |
| المصدر: | ISSN: 1323-7799. |
| بيانات النشر: | HAL CCSD Wiley |
| سنة النشر: | 2022 |
| المجموعة: | Université de Rennes 1: Publications scientifiques (HAL) |
| مصطلحات موضوعية: | clinical trial, death, fibrosing interstitial lung disease, forced vital capacity, pulmonary fibrosis, pulmonary function test, [SDV]Life Sciences [q-bio] |
| الوصف: | International audience ; Background and objective Demographic and clinical variables, measured at baseline or over time, have been associated with mortality in subjects with progressive fibrosing interstitial lung diseases (ILDs). We used data from the INPULSIS trials in subjects with idiopathic pulmonary fibrosis (IPF) and the INBUILD trial in subjects with other progressive fibrosing ILDs to assess relationships between demographic/clinical variables and mortality. Methods The relationships between baseline variables and time-varying covariates and time to death over 52 weeks were analysed using pooled data from the INPULSIS trials and, separately, the INBUILD trial using a Cox proportional hazards model. Results Over 52 weeks, 68/1061 (6.4%) and 33/663 (5.0%) subjects died in the INPULSIS and INBUILD trials, respectively. In the INPULSIS trials, a relative decline in forced vital capacity (FVC) >10% predicted within 12 months (hazard ratio [HR] 3.77) and age (HR 1.03 per 1-year increase) were associated with increased risk of mortality, while baseline FVC % predicted (HR 0.97 per 1-unit increase) and diffusing capacity of the lungs for carbon monoxide (DLCO) % predicted (HR 0.77 per 1-unit increase) were associated with lower risk. In the INBUILD trial, a relative decline in FVC >10% predicted within 12 months (HR 2.60) and a usual interstitial pneumonia-like fibrotic pattern on HRCT (HR 2.98) were associated with increased risk of mortality, while baseline DLCO % predicted (HR 0.95 per 1-unit increase) was associated with lower risk. Conclusion These data support similarity in the course of lung injury between IPF and other progressive fibrosing ILDs and the value of FVC decline as a predictor of mortality. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | info:eu-repo/semantics/altIdentifier/pmid/35224814; hal-03629139; https://hal.science/hal-03629139Test; https://hal.science/hal-03629139/documentTest; https://hal.science/hal-03629139/file/resp14231.pdfTest; PUBMED: 35224814 |
| DOI: | 10.1111/resp.14231 |
| الإتاحة: | https://doi.org/10.1111/resp.14231Test https://hal.science/hal-03629139Test https://hal.science/hal-03629139/documentTest https://hal.science/hal-03629139/file/resp14231.pdfTest |
| حقوق: | http://creativecommons.org/licenses/byTest/ ; info:eu-repo/semantics/OpenAccess |
| رقم الانضمام: | edsbas.28DE7F61 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1111/resp.14231 |
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