Uremic Toxins and Vascular Calcification-Missing the Forest for All the Trees
| العنوان: | Uremic Toxins and Vascular Calcification-Missing the Forest for All the Trees |
|---|---|
| المؤلفون: | Pieter Evenepoel, Nikolas Rapp, Leon J. Schurgers, Peter Stenvinkel |
| المصدر: | Toxins Toxins, Vol 12, Iss 624, p 624 (2020) |
| بيانات النشر: | MDPI, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | CHRONIC KIDNEY-DISEASE, Vascular smooth muscle, Health, Toxicology and Mutagenesis, SMOOTH-MUSCLE-CELLS, uremic toxins, NF-KAPPA-B, lcsh:Medicine, Review, 030204 cardiovascular system & hematology, Bioinformatics, Kidney, Toxicology, Muscle, Smooth, Vascular, Pathogenesis, 0302 clinical medicine, uremia, cardiovascular disease, water-soluble uremic solutes, SERUM URIC-ACID, vascular smooth muscle cells, 0303 health sciences, Prognosis, Phenotype, middle molecules, C-REACTIVE PROTEIN, medicine.anatomical_structure, vascular calcification, Food Science & Technology, protein bound uremic solutes, medicine.symptom, Life Sciences & Biomedicine, Senescence, CORONARY-ARTERY CALCIFICATION, Inflammation, Cardiorenal syndrome, PLASMA LEPTIN LEVELS, 03 medical and health sciences, medicine, Animals, Humans, INDOXYL SULFATE, Renal Insufficiency, Chronic, 030304 developmental biology, Toxins, Biological, Science & Technology, Cardio-Renal Syndrome, business.industry, lcsh:R, NECROSIS-FACTOR-ALPHA, medicine.disease, Uremia, GLYCATION END-PRODUCT, business, chronic kidney disease |
| الوصف: | The cardiorenal syndrome relates to the detrimental interplay between the vascular system and the kidney. The uremic milieu induced by reduced kidney function alters the phenotype of vascular smooth muscle cells (VSMC) and promotes vascular calcification, a condition which is strongly linked to cardiovascular morbidity and mortality. Biological mechanisms involved include generation of reactive oxygen species, inflammation and accelerated senescence. A better understanding of the vasotoxic effects of uremic retention molecules may reveal novel avenues to reduce vascular calcification in CKD. The present review aims to present a state of the art on the role of uremic toxins in pathogenesis of vascular calcification. Evidence, so far, is fragmentary and limited with only a few uremic toxins being investigated, often by a single group of investigators. Experimental heterogeneity furthermore hampers comparison. There is a clear need for a concerted action harmonizing and standardizing experimental protocols and combining efforts of basic and clinical researchers to solve the complex puzzle of uremic vascular calcification. ispartof: TOXINS vol:12 issue:10 ispartof: location:Switzerland status: published |
| وصف الملف: | Electronic |
| اللغة: | English |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4874b43c082fbb80bdefe90548b9e72bTest https://lirias.kuleuven.be/handle/123456789/672669Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....4874b43c082fbb80bdefe90548b9e72b |
| قاعدة البيانات: | OpenAIRE |
| الوصف غير متاح. |