المؤلفون: Ling Zhang, Ze-Jun Dong, Zheng-Hui Li, Ji-Kai Liu, Liang-Yan Liu, Shuang Wang

المصدر: Natural Products and Bioprospecting

مصطلحات موضوعية: Stereochemistry, Tumor cells, Plant Science, Toxicology, Bioinformatics, Biochemistry, Analytical Chemistry, chemistry.chemical_compound, Cytotoxicity, Spectral data, Pharmacology, Ergosterol, biology, ergosterol, Organic Chemistry, Regular Article, biology.organism_classification, Polyporus, chemistry, Cell culture, cytotoxicity, Polyporus ellisii, Two-dimensional nuclear magnetic resonance spectroscopy, Human cancer, Food Science, basidiomycete

الوصف: Investigation of the culture of basidiomycete Polyporus ellisii led to the isolation of a novel compound 3β,9α,15α-trihydroxy-(22E,24R)-10(5→4)-abeo-ergosta-6,8(14),22-trien-5-one (1) with a new 5/7/6/5 ring system of ergosterol skeleton. In addition, five new steroids, 5β,6β-epoxy-3β,7α,9α-trihydroxy-(22E,24R)-ergosta-8(14),22-dien-15-one (2), 5β,6β-epoxy-3β,7α-dihydroxy-(22E,24R)-ergosta-8(14),22-dien-15-one (3), 5α,6α-epoxy-3β,9α,15α-trihydroxy-(22E,24R)-ergosta-8(14),22-dien-7-one (4), 15α-acetoxy-(22E,24R)-ergosta-4,6,8(14),22-tetraen-3-one (5), 15β-methoxy-(22E,24R)-ergosta-4,6,8(14),22-tetraen-3-one (6), along with four known ergosterols (7–10), were obtained. All structures were elucidated based on 1D and 2D NMR spectral data. New compounds were evaluated for cytotoxicity against five human cancer cell lines, only compound 4 was found to exhibit a favorable cytotoxicity profile toward all tested tumor cell lines.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b7f1cecdae64fe838acc95b0ac6569dTest
http://europepmc.org/articles/PMC4131608Test

المؤلفون: Liang Li, Tao Feng, Ji-Kai Liu, Zheng-Hui Li, Jian-Hai Ding

المصدر: Natural Products and Bioprospecting

مصطلحات موضوعية: Pharmacology, chemistry.chemical_classification, Boreostereum vibrans, Chemistry, Stereochemistry, Organic Chemistry, Pharmacology toxicology, sesquiterpenoid, Regular Article, Plant Science, dihydrobenzofuran, Toxicology, Biochemistry, Isozyme, Analytical Chemistry, lactone, Plant biochemistry, cadinane, Bioorganic chemistry, boreovibrin, Lactone, Food Science

الوصف: Seven cadinane sesquiterpenoids, named boreovibrins A–G (1–7), three dihydrobenzofurans (8–10), and two lactones (11 and 12), together with one known compound (13), were isolated from cultures of the basidiomycete Boreostereum vibrans. The new structures were elucidated by means of spectroscopic methods. Compounds 5, 6, and 11 showed weak inhibitory activities against isozymes of 11β-hydroxysteroid dehydrogenases (11β-HSD).

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b88b81bc755bc715643a9db059b9343cTest
https://doi.org/10.1007/s13659-012-0060-xTest

المؤلفون: Ji-Kai Liu, Zheng-Hui Li, Ze-Jun Dong, Tao Feng, Yan Li, Jia Su

المصدر: Natural Products and Bioprospecting

مصطلحات موضوعية: Pharmacology, Traditional medicine, biology, Chemistry, Organic Chemistry, Pharmacology toxicology, sesquiterpenoid, Regular Article, Plant Science, boledulin, Toxicology, Electronic Supplementary Material, biology.organism_classification, Biochemistry, Terpenoid, Analytical Chemistry, Boletus edulis, Plant biochemistry, Cytotoxic T cell, botryane, Human cancer, Food Science

الوصف: Three non-isoprenoid botryane sesquiterpenoids, named boledulins A-C (1–3), have been isolated from the cultures of basidiomycete Boletus edulis Bull. The structures were established by means of spectroscopic methods. Boledulin A (1) exhibited moderate inhibitory activity against five human cancer cell lines. Electronic Supplementary Material Supplementary material is available for this article at 10.1007/s13659-011-0005-9 and is accessible for authorized users.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::893f9eedea116762aaae86b0bec63384Test
http://europepmc.org/articles/PMC4131704Test

المؤلفون: Zheng-Hui Li, Ling Zhang, Tao Feng, Sheng-Tao Fang, Ji-Kai Liu, Ze-Jun Dong

المصدر: Natural Products and Bioprospecting

مصطلحات موضوعية: Pharmacology, Stereochemistry, Organic Chemistry, Pharmacology toxicology, Phellodon niger, diterpenoid, Regular Article, Plant Science, Biology, nigernin, Toxicology, Biochemistry, Terpenoid, Analytical Chemistry, cyathane, Plant biochemistry, Two-dimensional nuclear magnetic resonance spectroscopy, Bond cleavage, Food Science

الوصف: Four new cyathane-type diterpenoids, nigernins C-F (1–4), together with four known compounds, were isolated from the fruiting bodies of the basidiomycete Phellodon niger. The structures of these new compounds were established on the basis of spectroscopic analysis, including 1D and 2D NMR experiments. In addition, nigernin F (4) with an unusual 3,4-seco cyathane diterpenoid skeleton was found to occur in nature for the first time. It was suggested to be as an oxidation product of C-3-C-4 bond cleavage of nigernin E (3). Electronic Supplementary Material Supplementary material is available for this article at 10.1007/s13659-011-0002-z and is accessible for authorized users.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb1fdca2f08f0b5344d19a03b7bcb060Test
http://europepmc.org/articles/PMC4131705Test

المؤلفون: Ji-Kai Liu, Zheng-Hui Li, Liang-Yan Liu

المصدر: Chinese Journal of Natural Medicines. 11:71-73

مصطلحات موضوعية: biology, Chemistry, Monoterpene, Pleurotus eryngii, General Medicine, Food science, biology.organism_classification

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::01038a02cf64bbaa8974a6c654b1b72dTest
https://doi.org/10.3724/sp.j.1009.2013.00071Test

المؤلفون: Zhen-Zhu Zhao, Ji-Kai Liu, He-Ping Chen, Tao Feng, Zheng-Hui Li, Ze-Jun Dong

المصدر: Natural Products and Bioprospecting

مصطلحات موضوعية: Pharmacology, Drimane, Traditional medicine, Phellinidium sulphurascens, Organic Chemistry, Pharmacology toxicology, Plant Science, Fungus, Biology, Toxicology, biology.organism_classification, Bioinformatics, Biochemistry, 7,10-Epoxy-2,6,10-trimethyldodeca-2,11-diene, Analytical Chemistry, Plant biochemistry, Original Article, Food Science

الوصف: Four new sesquiterpenoids, namely 12-hydroxy-3-oxodrimenol (1), 11-hydroxyacetoxydrim-7-en-3β-ol (2), 2,6-dimethyl-7,10-epoxy-10-hydroxymethyldodeca-2,11-dien-6-ol (3), and 7,10-epoxy-2,6,10-trimethyldodeca-2,11-diene-4,6-diol (4), along with fourteen known compounds, were isolated from the cultures of Phellinidium sulphurascens. The structures of compounds 1–4 were established on the basis of extensive spectroscopic analysis. All of them were evaluated for their cytotoxic activities. Electronic supplementary material The online version of this article (doi:10.1007/s13659-014-0047-x) contains supplementary material, which is available to authorized users.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e4f7289d0e22344732b1376e4808fb71Test
https://pubmed.ncbi.nlm.nih.gov/25491089Test

المؤلفون: Liang-Yan Liu, Yan Li, Zheng-Hui Li, Jia Su, Ze-Jun Dong, Xing-Yao Li, Ji-Kai Liu

المصدر: Natural Products and Bioprospecting

مصطلحات موضوعية: Pharmacology, Mushroom, biology, Agrocybe, Stereochemistry, Chemistry, Organic Chemistry, Pharmacology toxicology, Regular Article, Plant Science, Toxicology, biology.organism_classification, Bioinformatics, fomannosane-type sesquiterpenoids, Biochemistry, Analytical Chemistry, Agrocybe salicacola, Plant biochemistry, agrocybins, Single crystal, Food Science

الوصف: Two novel fomannosane-type sesquiterpenoids, agrocybins H (1) and I (2), together with a known compound illudosin (3), were isolated from the culture broth of the mushroom Agrocybe salicacola. Their structures were elucidated by extensive spectroscopic analysis. The relative stereochemistry of 1 was determined by the use of single crystal X-ray crystallographic diffraction. Electronic Supplementary Material Supplementary material is available for this article at 10.1007/s13659-012-0031-2 and is accessible for authorized users.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f58782d0444df8cede80947cfd03ef04Test
http://europepmc.org/articles/PMC4131595Test

المؤلفون: Ji-Kai Liu, Zheng-Hui Li, Xia Yin, Tao Feng, Ying Leng

المصدر: Natural Products and Bioprospecting

مصطلحات موضوعية: Stereochemistry, Psathyrellaceae diterpenes, 11β hsd1, Dehydrogenase, Plant Science, Fungus, Toxicology, Electronic Supplementary Material, Bioinformatics, Biochemistry, Isozyme, Analytical Chemistry, Psathyrella candolleana, Ic50 values, 11β-HSD1, Pharmacology, biology, Chemistry, Organic Chemistry, Guanacastepenes P–T, biology.organism_classification, Plant biochemistry, Original Article, hormones, hormone substitutes, and hormone antagonists, Food Science

الوصف: Five new guanacastane-type diterpenes, named guanacastepenes P–T (1–5), were isolated from cultures of the fungus Psathyrella candolleana. Their structures were elucidated on the basis of extensive spectroscopic methods. All of the compounds were tested for their 11β-hydroxysteroid dehydrogenase (11β-HSD1) inhibitory activity. Compound 3 exhibited inhibitory activity against both human and mouse isozymes of 11β-HSD1 with IC50 values of 6.2 and 13.9 μM, respectively. Electronic supplementary material The online version of this article (doi:10.1007/s13659-014-0020-8) contains supplementary material, which is available to authorized users.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa1dc7663a065576c0a1c772b63ac407Test

المؤلفون: Xia Yin, Ji-Kai Liu, Rong-Hua Yin, Tao Feng, Zhen-Zhu Zhao, Zheng-Hui Li, Kun Wei, He-Ping Chen

المصدر: Natural Products and Bioprospecting

مصطلحات موضوعية: Pharmacology, Boreostereum vibrans, biology, Chemistry, Stereochemistry, Organic Chemistry, Pharmacology toxicology, Plant Science, Fungus, Toxicology, biology.organism_classification, Bioinformatics, Biochemistry, Analytical Chemistry, Vibralactone, Plant biochemistry, Original Article, Cultural broth, Food Science, Vibralactone derivatives

الوصف: Phytochemical reinvestigation on the cultural broth of Boreostereum vibrans led to the isolation of six new vibralactone derivatives, vibralactone N (1), vibralactone O (2), vibralactone P (3), 10-lactyl vibralactone G (4), (3S*, 4R*)-6-acetoxymethyl-2,2-dimethyl-3,4-dihydro-2H-chromene-3,4-diol (5), vibralactone Q (6). Their structures were elucidated by extensive spectroscopic methods.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d07b63906fc67b016cfa8d4b54823aa6Test

المؤلفون: Zheng-Hui Li, Ji-Kai Liu, Hua Guo, Tao Feng

المصدر: Natural Products and Bioprospecting

مصطلحات موضوعية: Pharmacology, Stereochemistry, Organic Chemistry, Pharmacology toxicology, Regular Article, Dehydrogenase, Tumor cells, Craterellus odoratus, Plant Science, Biology, Toxicology, Biochemistry, Isozyme, Analytical Chemistry, Plant biochemistry, Ic50 values, craterellones, Cytotoxicity, polyketides, Food Science

الوصف: Five new polyketides, craterellones A–E (1–5), were isolated from cultures of basidiomycete Craterellus odoratus, together with five known compounds (6–10). Structures of 1–5 were elucidated on the basis of extensive spectroscopic analysis. All compounds were evaluated for their inhibitory activities against one isozyme of 11β-hydroxysteroid dehydrogenase (11β-HSD1) and cytotoxic activities on five tumor cell lines. Compound 10 exhibited significant cytotoxicity against HL-60, SMMC-7721, A-549, MCF-7, and SW-480, with IC50 values of 0.50, 0.69, 0.64, 1.10, 0.54 µM, respectively. Electronic Supplementary Material Supplementary material is available for this article at 10.1007/s13659-012-0057-5 and is accessible for authorized users.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::00c02ba358fdce83df2f7e2316253824Test