التفاصيل البيبلوغرافية
| العنوان: |
Prognostic factors for recurrence after endoscopic sinus surgery for chronic rhinosinusitis with nasal polyps. |
| المؤلفون: |
Nakayama, Tsuguhisa1,2 nakayama-t@jikei.ac.jp, Asaka, Daiya2, Kanaya, Hiroaki1, Kuboki, Akihito1,2, Haruna, Shin-ichi1 |
| المصدر: |
Auris Nasus Larynx. Dec2016, Vol. 43 Issue 6, p641-647. 7p. |
| مصطلحات موضوعية: |
*SINUSITIS treatment, *NASAL polyps, *ENDOSCOPIC surgery, *DISEASE relapse, *MESSENGER RNA, *FOLLOW-up studies (Medicine), *PROGNOSIS, *RNA metabolism, *CHRONIC diseases, *CYTOKINES, *EOSINOPHILS, *INTERFERONS, *INTERLEUKINS, *LONGITUDINAL method, *NASAL mucosa, *PARANASAL sinuses, *POLYMERASE chain reaction, *RHINITIS, *SINUSITIS, *RETROSPECTIVE studies, *REVERSE transcriptase polymerase chain reaction, *LYMPHOCYTE count |
| مستخلص: |
Objective: In this study, we aimed to clarify the prognostic factors affecting the ethmoid condition during a long-term follow-up after endoscopic sinus surgery in patients with chronic rhinosinusitis with nasal polyps (CRSwNP).Methods: Thirty-six patients with CRSwNP underwent surgery from December 2008 to February 2012. All surgeries were performed by one surgeon, and all patients were followed up for at least 2 years postoperatively. We investigated the association of postoperative endoscopic findings with clinical parameters, mucosal eosinophil count and mRNA expression of CCL11, IL-5, and IFN-gamma in nasal polyps.Results: Seventeen patients (47.2%) had severe mucosal edema, and the patency of each sinus was not confirmed during the >2-year follow-up. The mucosal eosinophil count and two eosinophil-associated factors, namely the CCL11 and IL-5 mRNA levels, were higher in the severe mucosal edema group than in the control group. The severe mucosal edema group was divided into two subgroups: the steroid-responsive and -resistant groups. Five patients (13.9%) had frank polyp formation because the oral steroids were less effective. The mucosal eosinophil count was significantly different among the four groups, including the control group (p=0.001); however, the CCL11, IL-5, and IFN-gamma mRNA levels were not significantly different. Although the IL-5 mRNA level was not significantly different among the four groups, it tended to increase when the sinus condition worsened. In the severe mucosal edema group, a higher IL-5 mRNA level was associated with earlier severe mucosal edema in the ethmoid cavity.Conclusion: The IL-5 mRNA level is associated with the time of severe edema formation in the ethmoid cavity. This finding permits early intervention on the postoperative course and would prevent polyp recurrence. [ABSTRACT FROM AUTHOR] |
| قاعدة البيانات: |
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