دورية أكاديمية
Subsequent primary malignancies after diffuse large B-cell lymphoma in the modern treatment era.
| العنوان: | Subsequent primary malignancies after diffuse large B-cell lymphoma in the modern treatment era. |
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| المؤلفون: | Tao, Li, Clarke, Christina A, Rosenberg, Aaron S, Advani, Ranjana H, Jonas, Brian A, Flowers, Christopher R, Keegan, Theresa HM |
| المصدر: | British journal of haematology, vol 178, iss 1 |
| بيانات النشر: | eScholarship, University of California |
| سنة النشر: | 2017 |
| المجموعة: | University of California: eScholarship |
| مصطلحات موضوعية: | Humans, Melanoma, Thyroid Neoplasms, Neoplasms, Second Primary, Antineoplastic Agents, Registries, Incidence, Follow-Up Studies, Adolescent, Adult, Aged, Middle Aged, California, Female, Male, Leukemia, Myeloid, Acute, Lymphoma, Large B-Cell, Diffuse, Young Adult, Rituximab, cancer, diffuse large B-cell lymphoma, second primary malignancy, Clinical Research, Rare Diseases, Hematology |
| جغرافية الموضوع: | 72 - 80 |
| الوصف: | With the addition of rituximab and other treatment advances, survival after diffuse large B-cell lymphoma (DLBCL) has improved, but subsequent primary malignancies (SPMs) have emerged as an important challenge for DLBCL survivorship. We calculated standardized incidence ratios (SIRs) and 95% confidence intervals (CIs) for SPMs among 23879 patients who survived at least 1year after a first primary DLBCL diagnosed during 1989-2012, compared to the general population in California. Cumulative incidence (CMI) of SPMs, accounting for the competing risk of death, also was calculated. We found that the incidence of acute myeloid leukaemia (AML) nearly doubled in the post-rituximab era [SIR (95% CI) 4·39 (2·51-7·13) pre- (1989-2000) and 8·70 (6·62-11·22) post-rituximab (2001-2012)]. Subsequent thyroid cancer was rare pre-rituximab, but increased substantially after 2001 [0·66 (0·08-2·37) vs. 2·27(1·44-3·41)]. The 5-year CMI for all SPMs (4·77% pre- vs. 5·41% post-rituximab, P=0·047), AML (0·15% vs. 0·41%, P=0·003), thyroid cancer (0·03% vs. 0·15%, P=0·003) and melanoma (0·25% vs. 0·42%, P=0·020) were greater in DLBCL patients diagnosed in the post- versus pre-rituximab period. This study provides insight into the changing pattern of SPM occurrence after the introduction of rituximab, which may elucidate the aetiology of SPMs and should guide future cancer surveillance efforts among DLBCL patients. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | unknown |
| العلاقة: | qt6v63t6xs; https://escholarship.org/uc/item/6v63t6xsTest; https://escholarship.org/content/qt6v63t6xs/qt6v63t6xs.pdfTest |
| DOI: | 10.1111/bjh.14638 |
| الإتاحة: | https://doi.org/10.1111/bjh.14638Test https://escholarship.org/uc/item/6v63t6xsTest https://escholarship.org/content/qt6v63t6xs/qt6v63t6xs.pdfTest |
| حقوق: | CC-BY-NC-ND |
| رقم الانضمام: | edsbas.301F827F |
| قاعدة البيانات: | BASE |
| DOI: | 10.1111/bjh.14638 |
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