التفاصيل البيبلوغرافية
| العنوان: |
Investigating the mechanism of acoustically activated uptake of drugs from Pluronic micelles. |
| المؤلفون: |
Husseini, Ghaleb A.1 ghaleb_husseini@hotmail.com, Runyan, Christopher M.2 cmr22@email.byu.edu, Pitt, William G.1 pitt@byu.edu |
| المصدر: |
BMC Cancer. 2002, Vol. 2, p20-6. 6p. 5 Graphs. |
| مصطلحات موضوعية: |
*MICELLES, *FLUORESCENT probes, *HELA cells, *DRUG therapy, *DRUGS |
| مستخلص: |
Background: This paper examines the mechanism of ultrasonic enhanced drug delivery from Pluronic micelles. In previous publications by our group, fluorescently labeled Pluronic was shown to penetrate HL-60 cells with and without the action of ultrasound, while drug uptake was increased with the application of ultrasound. Methods: In this study, the amount of uptake of two fluorescent probes, Lysosensor Green (a pH-sensitive probe) and Cell Tracker Orange CMTMR (a pH-independent probe), was measured in HL-60 and HeLa cells. Results: The results of our experiments show that the increase in drug accumulation in the cells as a result of ultrasonication is not due to an increase in endocytosis due to ultrasonication. Conclusions: We hypothesize that sonoporation plays an important role in the acoustically activated drug delivery of chemotherapy drugs delivered from Pluronic micelles. [ABSTRACT FROM AUTHOR] |
| قاعدة البيانات: |
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