Predicting the 'usefulness' of 5-ALA-derived tumor fluorescence for fluorescence-guided resections in pediatric brain tumors:a European survey
| العنوان: | Predicting the 'usefulness' of 5-ALA-derived tumor fluorescence for fluorescence-guided resections in pediatric brain tumors:a European survey |
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| المؤلفون: | Stummer, Walter, Rodrigues, Floriano, Schucht, Philippe, Preuss, Matthias, Wiewrodt, Dorothee, Nestler, Ulf, Stein, Marco, Artero, José Manuel Cabezudo, Platania, Nunzio, Skjøth-Rasmussen, Jane, Della Puppa, Alessandro, Caird, John, Cortnum, Søren, Cortnum, Søren Ole Stigaard, Eljamel, Sam, Ewald, Christian, González-García, Laura, Martin, Andrew J, Melada, Ante, Peraud, Aurelia, Brentrup, Angela, Santarius, Thomas, Steiner, Hans Herbert |
| المصدر: | Stummer, W, Rodrigues, F, Schucht, P, Preuss, M, Wiewrodt, D, Nestler, U, Stein, M, Artero, J M C, Platania, N, Skjøth-Rasmussen, J, Della Puppa, A, Caird, J, Cortnum, S, Eljamel, S, Ewald, C, González-García, L, Martin, A J, Melada, A, Peraud, A, Brentrup, A, Santarius, T, Steiner, H H & European ALA Pediatric Brain Tumor Study Group 2014, ' Predicting the "usefulness" of 5-ALA-derived tumor fluorescence for fluorescence-guided resections in pediatric brain tumors : a European survey ', Acta Neurochirurgica, vol. 156, no. 12, pp. 2315-2324 . https://doi.org/10.1007/s00701-014-2234-2Test Acta Neurochirurgica Cortnum, S O S & European ALA Pediatric Brain Tumor Study Group 2014, ' Predicting the "usefulness" of 5-ALA-derived tumor fluorescence for fluorescence-guided resections in pediatric brain tumors : a European survey ', Acta Neurochirurgica, vol. 156, no. 12, pp. 2315-24 . https://doi.org/10.1007/s00701-014-2234-2Test Stummer, Walter; Rodrigues, Floriano; Schucht, Philippe; Preuss, Matthias; Wiewrodt, Dorothee; Nestler, Ulf; Stein, Marco; Artero, José Manuel Cabezudo; Platania, Nunzio; Skjøth-Rasmussen, Jane; Della Puppa, Alessandro; Caird, John; Cortnum, Søren; Eljamel, Sam; Ewald, Christian; González-García, Laura; Martin, Andrew J; Melada, Ante; Peraud, Aurelia; Brentrup, Angela; ... (2014). Predicting the "usefulness" of 5-ALA-derived tumor fluorescence for fluorescence-guided resections in pediatric brain tumors: a European survey. Acta neurochirurgica, 156(12), pp. 2315-2324. Springer 10.1007/s00701-014-2234-2 <http://dx.doi.org/10.1007/s00701-014-2234-2Test> |
| سنة النشر: | 2014 |
| مصطلحات موضوعية: | Oncology, Ependymoma, Male, Aminolevulinic Acid/analysis, Pediatric brain tumor, Contrast Media, Brain Neoplasms/surgery, Neurosurgical Procedures, Glioma/surgery, Neurosurgical Procedures/methods, Prospective cohort study, Child, Neuroradiology, Brain Neoplasms, Data Collection, Optical Imaging, Glioma, Magnetic Resonance Imaging, Europe, Child, Preschool, Female, Neurosurgery, Anaplastic astrocytoma, medicine.medical_specialty, Adolescent, Clinical Neurology, 610 Medicine & health, Fluorescence, Clinical Article - Pediatrics, Internal medicine, Gliolan, medicine, Humans, Medical physics, 5-ALA, Retrospective Studies, Medulloblastoma, business.industry, Infant, Retrospective cohort study, Aminolevulinic Acid, Fluorescence-guided resection, medicine.disease, Optical Imaging/methods, Surgery, Neurology (clinical), business, Glioblastoma |
| الوصف: | BACKGROUND: Five-aminolevulinic acid (Gliolan, medac, Wedel, Germany, 5-ALA) is approved for fluorescence-guided resections of adult malignant gliomas. Case reports indicate that 5-ALA can be used for children, yet no prospective study has been conducted as of yet. As a basis for a study, we conducted a survey among certified European Gliolan users to collect data on their experiences with children.METHODS: Information on patient characteristics, MRI characteristics of tumors, histology, fluorescence qualities, and outcomes were requested. Surgeons were further asked to indicate whether fluorescence was "useful", i.e., leading to changes in surgical strategy or identification of residual tumor. Recursive partitioning analysis (RPA) was used for defining cohorts with high or low likelihoods for useful fluorescence.RESULTS: Data on 78 patients CONCLUSIONS: Our survey demonstrates 5-ALA as being used in pediatric brain tumors. 5-ALA may be especially useful for contrast-enhancing supratentorial tumors. These data indicate controlled studies to be necessary and also provide a basis for planning such a study. |
| وصف الملف: | application/pdf |
| اللغة: | English |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cffbb72dc42d69c6f5e92201ebec3235Test https://vbn.aau.dk/da/publications/279e9e2b-c606-4969-987d-d35b34b1c120Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....cffbb72dc42d69c6f5e92201ebec3235 |
| قاعدة البيانات: | OpenAIRE |
| الوصف غير متاح. |