High nocturnal sleep fragmentation is associated with low T lymphocyte P2Y11protein levels in narcolepsy type 1
| العنوان: | High nocturnal sleep fragmentation is associated with low T lymphocyte P2Y11protein levels in narcolepsy type 1 |
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| المؤلفون: | Benedicte A. Lie, Sebjørg E H Nordstrand, Birgitte Rahbek Kornum, Hilde T Juvodden, Stine Knudsen-Heier, Marte K. Viken, Per Medbøe Thorsby, Rannveig Viste, Terje Rootwelt |
| المصدر: | Viste, R, Viken, M K, Lie, B A, Juvodden, H T, Nordstrand, S E H, Thorsby, P M, Rootwelt, T, Kornum, B R & Knudsen-Heier, S 2021, ' High nocturnal sleep fragmentation is associated with low T lymphocyte P2Y 11 protein levels in narcolepsy type 1 ', Sleep, vol. 44, no. 8, zsab062 . https://doi.org/10.1093/sleep/zsab062Test Sleep |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | medicine.medical_specialty, P2Y11, T-Lymphocytes, Single-nucleotide polymorphism, Neurological Disorders, P2RY11, 03 medical and health sciences, Influenza A Virus, H1N1 Subtype, 0302 clinical medicine, Polymorphism (computer science), Physiology (medical), Internal medicine, medicine, Humans, Pandemrix, sleep fragmentation, AcademicSubjects/MED00385, Allele, First-degree relatives, narcolepsy 1, Narcolepsy, 030304 developmental biology, 0303 health sciences, AcademicSubjects/SCI01870, business.industry, T lymphocyte, P2Y, medicine.disease, Endocrinology, Influenza Vaccines, Sleep Deprivation, Neurology (clinical), Sleep, business, 030217 neurology & neurosurgery, CD8, AcademicSubjects/MED00370 |
| الوصف: | Study Objectives Narcolepsy type 1 (NT1) is associated with hypocretin neuron loss. However, there are still unexplained phenotypic NT1 features. We investigated the associations between clinical and sleep phenotypic characteristics, the NT1-associated P2RY11 polymorphism rs2305795, and P2Y11 protein levels in T lymphocytes in patients with NT1, their first-degree relatives and unrelated controls. Methods The P2RY11 SNP was genotyped in 100 patients (90/100 H1N1-(Pandemrix)-vaccinated), 119 related and 123 non-related controls. CD4 and CD8 T lymphocyte P2Y11 protein levels were quantified using flow cytometry in 167 patients and relatives. Symptoms and sleep recording parameters were also collected. Results We found an association between NT1 and the rs2305795 A allele (OR = 2, 95% CI (1.3, 3.0), p = 0.001). T lymphocyte P2Y11 protein levels were significantly lower in patients and relatives homozygous for the rs2305795 risk A allele (CD4: p = 0.012; CD8: p = 0.007). The nocturnal sleep fragmentation index was significantly negatively correlated with patients’ P2Y11 protein levels (CD4: p = 0.004; CD8: p = 0.006). Mean MSLT sleep latency, REM-sleep latency, and core clinical symptoms were not associated with P2Y11 protein levels. Conclusions We confirmed that the P2RY11 polymorphism rs2305795 is associated with NT1 also in a mainly H1N1-(Pandemrix)-vaccinated cohort. We demonstrated that homozygosity for the A risk allele is associated with lower P2Y11 protein levels. A high level of nocturnal sleep fragmentation was associated with low P2Y11 levels in patients. This suggests that P2Y11 has a previously unknown function in sleep-wake stabilization that affects the severity of NT1. |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 0161-8105 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::30e93714b2858b3f44f3e71869886cffTest https://curis.ku.dk/portal/da/publications/high-nocturnal-sleep-fragmentation-is-associated-with-low-t-lymphocyte-p2y11protein-levels-in-narcolepsy-type-1Test(9b7b73c5-e944-45fd-895c-180f46233f2b).html |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....30e93714b2858b3f44f3e71869886cff |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 01618105 |
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