التفاصيل البيبلوغرافية
| العنوان: |
Cytological and Ultrasound Features of Thyroid Nodules Correlate With Histotypes and Variants of Thyroid Carcinoma. |
| المؤلفون: |
Sgrò, Daniele, Brancatella, Alessandro, Greco, Giuseppe, Torregrossa, Liborio, Piaggi, Paolo, Viola, Nicola, Rago, Teresa, Basolo, Fulvio, Giannini, Riccardo, Materazzi, Gabriele, Elisei, Rossella, Santini, Ferruccio, Latrofa, Francesco |
| المصدر: |
Journal of Clinical Endocrinology & Metabolism; Nov2023, Vol. 108 Issue 11, pe1186-e1192, 7p |
| مصطلحات موضوعية: |
CYTOLOGY, THYROID nodules, THYROID cancer |
| مستخلص: |
Context: Prognosis is excellent for papillary thyroid carcinoma (PTC), noninvasive follicular thyroid neoplasia with papillary-like nuclear features (NIFT-P), and follicular thyroid carcinoma (FTC) but is poor for poorly differentiated thyroid carcinoma (PDTC) and anaplastic thyroid carcinoma (ATC). Among PTCs, the prognosis is more favorable for follicular (FV-PTC) and classic (CV-PTC) than for tall cell (TCV-PTC), and solid (SV-PTC) variants. Objective: To associate histotypes and variants of thyroid carcinoma with ultrasound and cytological features. Methods: Histology of 1018 benign tumors and 514 PTC (249 CV, 167 FV, 49 TC, 34 SV, and 15 other variants), 52 NIFT-P, 50 FTC, 11 PDTC, and 3 ATC was correlated with fine-needle aspiration biopsy categories (Italian classification: TIR1, TIR2, TIR3A, TIR3B, TIR4, and TIR5) and ultrasound features at the Endocrinology Unit, University Hospital of Pisa. In total, 1117 patients with thyroid nodule(s) who underwent thyroidectomy were included. Results: Of PTC, 36.3% had indeterminate cytology (TIR3A or TIR3B), 56.6% were suspicious for malignancy or malignant (TIR4 or TIR5); 84.0% FTC and 69.3% NIFT-P were TIR3A or TIR3B; 72.5% FV-PTC and 73.6% SV-PTC were TIR3A or TIR3B; 79.9% CV-PTC and 95.9% TCV-PTC were TIR4 or TIR5. The association of a hypoechoic pattern, irregular margins, and no microcalcifications was more frequent in TCV-PTC than in CV-PTC (P = .02, positive predictive value = 38.9%; negative predictive value = 85.5%). Conclusion: At cytology, most FTC, NIFT-P, FV-PTC, and SV-PTC were indeterminate, most CV-PTC and TCV-PTC were suspicious for malignancy or malignant. Ultrasound can be helpful in ruling out TCV-PTC. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
