دورية أكاديمية
Fast inactivation of coronavirus in filtering-facepiece respirators in a reflective cylindrical UV-C chamber
| العنوان: | Fast inactivation of coronavirus in filtering-facepiece respirators in a reflective cylindrical UV-C chamber |
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| المؤلفون: | Marilia Wellichan Mancini, Luciana Almeida-Lopes, Paulo Sérgio Bossini, Gislaine Santos Jacintho, Junko Tsukamoto, Clarice Weis Arns |
| المصدر: | Journal of Photochemistry and Photobiology, Vol 12, Iss , Pp 100151- (2022) |
| بيانات النشر: | Elsevier |
| سنة النشر: | 2022 |
| المجموعة: | Directory of Open Access Journals: DOAJ Articles |
| مصطلحات موضوعية: | COVID-19, UV-C light, FFR, N95, PFF2, Reuse, Chemistry, QD1-999 |
| الوصف: | Objective: We report on the development and characterization of a UV-C (λ = 200 – 280 nm, λpeak = 254 nm) chamber designed for the rapid disinfection of N95 class filtering-facepiece respirators contaminated with SARS-CoV-2 coronaviruses. The device was evaluated against Betacoronavirus strain MHV-3 and its virucidal capacity was evaluated as a function of different applied UV-C doses (UV-C exposure times of 60 s, 120 s, 180 s, and 240 s) using two types of respirators geometry (shell and two-panel shapes, 3M 8801 H and 9920 H, respectively), at eight points of the respirators. Background: Most chemical disinfection methods are not recommended for N95 masks. UV-C light provided by UVGI lamps (254 nm) is an effective physical agent against viruses and bacteria due to direct photochemical harming effect on DNA/RNA, and can provide rapid disinfection for personal protective equipment such as N95/PFF2 masks. Results: The device reached a mean elimination rate of 99.9999% of MHV-3 inoculated into all the assessed different points on the tested PFF2 respirator models in a UV-C cycle of just 60 s. Statistical analysis performed through Person´s chi-square test showed no correlation between the viral infectivity reduction and the viral inoculation point (p = 0.512) and the tested respirator models (p = 0.556). However, a correlation was found between the exposure time and the viral infectivity reduction (p = 0.000*), between UV-C and no UV-C exposure. All the tested UV-C exposure times (60 s, 120 s, 180 s, and 240 s) provided the same reduction in infection rates. Therefore, 60 s was confirmed as the minimum exposure time to achieve a 99.9999% or 6 Log reduction in MHV-3 coronavirus infection rates in the PFF2 samples tested in the device. Conclusions: We conclude that the assessed UV-C chamber for the inactivation of MHV-3 coronavirus in N95/PFF2 standard masks can be a promising tool for effective and rapid disinfection of coronaviruses, including SARS-CoV-2 virus. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 2666-4690 |
| العلاقة: | http://www.sciencedirect.com/science/article/pii/S2666469022000446Test; https://doaj.org/toc/2666-4690Test; https://doaj.org/article/ad03071082f04308b15c44a62b9fd7e5Test |
| DOI: | 10.1016/j.jpap.2022.100151 |
| الإتاحة: | https://doi.org/10.1016/j.jpap.2022.100151Test https://doaj.org/article/ad03071082f04308b15c44a62b9fd7e5Test |
| رقم الانضمام: | edsbas.10D199DF |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 26664690 |
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| DOI: | 10.1016/j.jpap.2022.100151 |