دورية أكاديمية
Spontaneous fertility and pregnancy outcomes amongst 480 women with Turner syndrome
| العنوان: | Spontaneous fertility and pregnancy outcomes amongst 480 women with Turner syndrome |
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| المؤلفون: | Bernard, Valérie, Donadille, Bruno, Zenaty, Delphine, Courtillot, Carine, Salenave, Sylvie, Perrière, Aude, Brac de La, Albarel, Frédérique, Fèvre, Anne, Kerlan, Véronique, Brue, Thierry, Delemer, Brigitte, Borson-Chazot, Françoise, Carel, Jean-Claude, Chanson, Philippe, Leger, Juliane, Touraine, Philippe, Christin-Maitre, Sophie |
| المساهمون: | CHU Pitié-Salpêtrière AP-HP, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), CHU Saint-Antoine AP-HP, Service de pédiatrie générale, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Robert Debré-Université Paris Diderot - Paris 7 (UPD7), Université Pierre et Marie Curie - Paris 6 (UPMC), Sorbonne Université (SU), Service d'endocrinologie, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Bicêtre, Groupement Hospitalier Lyon-Est (GHE), Hospices Civils de Lyon (HCL), Centre de recherche en neurobiologie - neurophysiologie de Marseille (CRN2M), Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Hôpital universitaire Robert Debré Reims, Service d'Endocrinologie (CHRU - Endocrino), Centre Hospitalier Régional Universitaire de Brest (CHRU Brest), Groupe d'Etude de la Thrombose de Bretagne Occidentale (GETBO), Université de Brest (UBO)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut Brestois Santé Agro Matière (IBSAM), Université de Brest (UBO)-Université de Brest (UBO), Hôpital de la Cavale Blanche - CHRU Brest (CHU - BREST ), Service d'Endocrinologie - Diabète - Nutrition Reims, Université de Reims Champagne-Ardenne (URCA)-Hôpital Robert Debré-Hôpital universitaire Robert Debré Reims, Centre de Recherche en Cancérologie de Lyon (UNICANCER/CRCL), Centre Léon Bérard Lyon -Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Neuroprotection du Cerveau en Développement / Promoting Research Oriented Towards Early Cns Therapies (PROTECT), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Robert Debré-Université Paris Diderot - Paris 7 (UPD7)-Institut National de la Santé et de la Recherche Médicale (INSERM), Service d'endocrinologie diabétologie pédiatrique CHU Debré, AP-HP Hôpital universitaire Robert-Debré Paris, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Signalisation Hormonale, Physiopathologie Endocrinienne et Métabolique, Université Paris-Sud - Paris 11 (UP11)-Institut National de la Santé et de la Recherche Médicale (INSERM)-AP-HP Hôpital Bicêtre (Le Kremlin-Bicêtre), Centre de Référence des Maladies Endocriniennes Rares de la Croissance APHP Robert Debré, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Robert Debré-Université Paris Cité (UPCité), Physiopathologie des maladies génétiques d'expression pédiatrique, Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de la Santé et de la Recherche Médicale (INSERM), CMERC Center for Rare Disease |
| المصدر: | ISSN: 0268-1161. |
| بيانات النشر: | HAL CCSD Oxford University Press (OUP) |
| سنة النشر: | 2016 |
| المجموعة: | Université de Toulon: HAL |
| مصطلحات موضوعية: | Adolescent, Adult, Aged, Cohort Studies, Female, female infertility, Fertility, fertility preservation, Follow-Up Studies, France, Humans, Menarche, Middle Aged, monosomy X, Mosaicism, Pregnancy, Pregnancy Complications, Cardiovascular, Pregnancy Outcome, Pregnancy Rate, Primary Ovarian Insufficiency, Registries, Reproductive History, Time-to-Pregnancy, Turner Syndrome, Young Adult, [SDV.NEU.NB]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Neurobiology |
| الوصف: | International audience ; STUDY QUESTION: What are the prevalence and the outcomes of spontaneous pregnancies (SP) in a large cohort of French women with Turner syndrome (TS)?ăSUMMARY ANSWER: Amongst 480 women with TS, 27 women (5.6%) had a total of 52 SP, with 30 full-term deliveries for 18 women.ăWHAT IS KNOWN ALREADY: Primary ovarian insufficiency is a classic feature of TS. So far, few studies have evaluated the rate of SP in these patients.ăSTUDY DESIGN, SIZE, DURATION: The French Ministry of Health set up a National Reference Centre for Rare Growth Disorders (CRMERC), including TS. We studied a cohort of adult TS patients from seven endocrine units (Saint-Antoine, Pitié-Salpêtrière, Bicêtre, Lyon, Marseille, Brest, Reims Hospitals) belonging to this centre, between January 1999 and January 2014.ăPARTICIPANTS/MATERIALS, SETTING, METHODS: A total of 480 adult patients with TS were included. The patients' clinical characteristics, karyotypes and reproductive histories had been collected, after informed consent, in a web database called CEMARA. Our reference population was issued from a database belonging to the French Health Ministry, collecting pregnancy outcomes in the French general population. In order to find predictive characteristics of SP, TS with spontaneous pregnancies were compared with non-pregnant TS patients from our cohort.ăMAIN RESULTS AND THE ROLE OF CHANCE: There were 27 patients (5.6%) who had a total of 52 SP. The two predictive factors which correlated with occurrence of a SP were spontaneous menarche and mosaic karyotype. The median delay to conception was 6 months (range 0-84). Miscarriage occurred in 16 pregnancies, 30.8% versus 15% in the general French population (P \textless 0.01). The remaining pregnancy outcomes were legal abortion (n = 2), medical interruption (n = 3), intrauterine fetal death (n = 1) and delivery at term (n = 30). Caesarean section rates were higher than in the general population, respectively 46.7% versus 21% (P \textless 0.001). Pregnancy-induced hypertensive ... |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | info:eu-repo/semantics/altIdentifier/pmid/26874361; hal-01473964; https://hal.science/hal-01473964Test; PUBMED: 26874361; WOS: 000374228200010 |
| DOI: | 10.1093/humrep/dew012 |
| الإتاحة: | https://doi.org/10.1093/humrep/dew012Test https://hal.science/hal-01473964Test |
| رقم الانضمام: | edsbas.41F916C7 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1093/humrep/dew012 |
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