التفاصيل البيبلوغرافية
| العنوان: |
Post-COVID-19 illness and associations with sex and gender. |
| المؤلفون: |
Mangion, Kenneth, Morrow, Andrew J., Sykes, Robert, Kamdar, Anna, Bagot, Catherine, Bruce, George, Connelly, Paul, Delles, Christian, Gibson, Vivienne B., Gillespie, Lynsey, Barrientos, Pauline Hall, Lennie, Vera, Roditi, Giles, Sattar, Naveed, Stobo, David, Allwood-Spiers, Sarah, McConnachie, Alex, Berry, Colin, CISCO-19 investigators, Blyth, Kevin G. |
| المصدر: |
BMC Cardiovascular Disorders; 8/8/2023, Vol. 23 Issue 1, p1-13, 13p |
| مصطلحات موضوعية: |
PATIENT reported outcome measures, GENDER, COVID-19 pandemic, CARDIAC magnetic resonance imaging, COVID-19, MAYER-Rokitansky-Kuster-Hauser syndrome |
| مستخلص: |
Background: Post-COVID-19 syndromes have associated with female sex, but the pathophysiological basis is uncertain. Aim: There are sex differences in myocardial inflammation identified using cardiac magnetic resonance (CMR) in post-COVID-19 patients, and in patient reported health outcomes following COVID-19 infection. Design: This prospective study investigated the time-course of multiorgan injury in survivors of COVID-19 during convalescence. Methods: Clinical information, blood biomarkers, and patient reported outcome measures were prospectively acquired at enrolment (visit 1) and 28–60 days post-discharge (visit 2). Chest computed tomography (CT) and CMR were performed at visit 2. Follow-up was carried out for serious adverse events, including death and rehospitalization. Results: Sixty-nine (43%) of 159 patients recruited were female. During the index admission, females had a lower peak C-reactive protein (74 mg/l (21,163) versus 123 mg/l (70, 192) p = 0.008) and peak ferritin (229 μg/l (103, 551) versus 514 μg/l (228, 1122) p < 0.001). Using the Modified Lake-Louise criteria, females were more likely to have definite evidence of myocardial inflammation (54% (37/68) versus 33% (30/90) p = 0.003). At enrolment and 28–60 days post-discharge, enhanced illness perception, higher levels of anxiety and depression and lower predicted maximal oxygen utilization occurred more commonly in women. The mean (SD, range) duration of follow-up after hospital discharge was 450 (88) days (range 290, 627 days). Compared to men, women had lower rates of cardiovascular hospitalization (0% versus 8% (7/90); p = 0.018). Conclusions: Women demonstrated worse patient reported outcome measures at index admission and 28–60 days follow-up though cardiovascular hospitalization was lower. [ABSTRACT FROM AUTHOR] |
|
Copyright of BMC Cardiovascular Disorders is the property of BioMed Central and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) |
| قاعدة البيانات: |
Complementary Index |
Full Text Finder