التفاصيل البيبلوغرافية
| العنوان: |
Immunology and Endometriosis. |
| المؤلفون: |
Berkkanoglu, Murat1, Arici, Aydin1 |
| المصدر: |
American Journal of Reproductive Immunology. Jul2003, Vol. 50 Issue 1, p48-59. 12p. |
| مصطلحات موضوعية: |
*ENDOMETRIOSIS, *MENSTRUATION, *FEMALE infertility, *FEMALE reproductive organ diseases, *IMMUNOLOGY, *KILLER cells |
| مستخلص: |
Problem: Accumulating data suggests that aberrant immune responses during retrograde menstruation may be involved in the development of endometriosis. Method of Study: The role of immunology in the etiology of endometriosis is reviewed and summarized from the available literature. Results: Immunologic factors may affect a woman's susceptibility to implantation of exfoliated endometrial cells. Immune alterations include increased number and activation of peritoneal macrophages, decreased T cell reactivity and natural killer cell cytotoxicity, increased circulating antibodies, and changes in the cytokine network. Conclusion: There is substantial evidence that immunologic factors play a role in the pathogenesis of endometriosis and endometriosis-associated infertility. Decreased natural killer cell cytotoxicity leads to an increased likelihood of implantation of endometriotic tissue. In addition, macrophages and a complex network of locally produced cytokines modulate the growth and inflammatory behavior of ectopic endometrial implants. [ABSTRACT FROM AUTHOR] |
| قاعدة البيانات: |
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