نتائج البحث - "integrin-linked kinase"

1

Substratum stiffness signals through integrin-linked kinase and β1-integrin to regulate midbody proteins and abscission during EMT

المؤلفون: Celeste M. Nelson, Emann M Rabie, Sherry X. Zhang, Connor E. Dunn

المصدر: Molecular Biology of the Cell

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2aabde3868c45601b0e7f0d43616721dTest
https://doi.org/10.1091/mbc.e21-02-0072Test

2

Loss of Integrin-linked kinase sensitizes breast cancer to SRC inhibitors

المؤلفون: Henry Beetham, Billie G.C. Griffith, Olga Murina, Alexander E.P. Loftus, David A. Parry, Carolin Temps, Jayne Culley, Morwenna Muir, Asier Unciti-Broceta, Andrew H. Sims, Adam Byron, Valerie G. Brunton

المصدر: Beetham, H, Griffith, B, Murina, O, Loftus, A, Parry, D A, Temps, C, Culley, J, Muir, M, Unciti-Broceta, A, Sims, A H, Byron, A & Brunton, V G 2021, ' Loss of Integrin-linked kinase sensitizes breast cancer to SRC inhibitors ', Cancer Research . https://doi.org/10.1158/0008-5472.CAN-21-0373Test
Beetham, H, Griffith, B G C, Murina, O, Loftus, A E P, Parry, D A, Temps, C, Culley, J, Muir, M, Unciti-Broceta, A, Sims, A H, Byron, A & Brunton, V G 2022, ' Loss of Integrin-linked kinase sensitizes breast cancer to SRC inhibitors ', Cancer Research, vol. 82, no. 4, pp. 632-647 . https://doi.org/10.1158/0008-5472.CAN-21-0373Test

مصطلحات موضوعية: Cancer Research, Breast Neoplasms, Aniline Compounds/pharmacology, Kaplan-Meier Estimate, bosutinib, Protein Serine-Threonine Kinases, Breast Neoplasms/enzymology, Cell Proliferation/drug effects, Gene Knockout Techniques, Breast cancer, Cell Line, Tumor, Signal Transduction/drug effects, Nitriles, Animals, Humans, Integrin-linked kinase, Protein Kinase Inhibitors, Cell Proliferation, Mice, Knockout, Quinolines/pharmacology, Aniline Compounds, Gene Expression Profiling, Xenograft Model Antitumor Assays, synthetic lethality, Gene Expression Regulation, Neoplastic, src-Family Kinases, src-Family Kinases/antagonists & inhibitors, Xenograft Model Antitumor Assays/methods, Oncology, Protein Kinase Inhibitors/pharmacology, Nitriles/pharmacology, Quinolines, MCF-7 Cells, Female, Protein Serine-Threonine Kinases/genetics, Gene Expression Profiling/methods, Signal Transduction, SRC

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e60490b72d4b6e9896c2cb3f20e716f6Test
https://www.pure.ed.ac.uk/ws/files/245549967/Loss_of_Integrin_linked_kinase_sensitizes_breast_cancer_to_SRC_inhibitors_published_AAM.pdfTest

3

Serum deprivation‐response protein regulates aldehyde dehydrogenase 1 through integrin‐linked kinase signaling in endometrioid carcinoma cells

المؤلفون: Masako Kurashige, Jun-ichiro Ikeda, Satoshi Nojima, Eiichi Morii, Daisuke Okuzaki, Yumiko Hori, Naoki Wada, Shinichiro Tahara, Kenji Ohshima, Yuichi Motoyama

المصدر: Cancer Science

مصطلحات موضوعية: 0301 basic medicine, Gene isoform, Cancer Research, Epithelial-Mesenchymal Transition, Aldehyde dehydrogenase, Biology, integrin‐linked kinase, Protein Serine-Threonine Kinases, Aldehyde Dehydrogenase 1 Family, 03 medical and health sciences, 0302 clinical medicine, Cell Movement, Cell Line, Tumor, Pathology, serum deprivation‐response protein, Humans, Integrin-linked kinase, Neoplasm Invasiveness, aldehyde dehydrogenase 1, Cell Proliferation, Kinase, microcystic, elongated and fragmented, Retinal Dehydrogenase, General Medicine, Original Articles, Aldehyde Dehydrogenase, Phosphate-Binding Proteins, Molecular biology, Endometrial Neoplasms, Gene Expression Regulation, Neoplastic, 030104 developmental biology, Oncology, Tumor progression, 030220 oncology & carcinogenesis, biology.protein, Original Article, Female, Stem cell, SDPR, Carrier Proteins, Carcinoma, Endometrioid, Cavin, endometrioid carcinoma, Signal Transduction

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d08bc10b6b0cd70b16a466deaeabf65fTest
http://europepmc.org/articles/PMC6500992Test

4

دورية أكاديمية

Loss-of-function mutations in ELMO2 cause intraosseous vascular malformation by impeding RAC1 signaling

المساهمون: Uludağ Üniversitesi/Fen-Edebiyat Fakültesi/Moleküler Biyoloji ve Genetik Bölümü., orcid:0000-0002-1459-5485, Uz, Elif, 13807893000

مصطلحات موضوعية: Genetics & heredity, Integrin-linked kinase, Craniofacial region, Sequencing data, Cell-migration, Angiogenesis, Mechanism, Complex, Lesions, Growth, Bone, Adaptor proteins, signal transducing, Adult, Alleles, Animals, Bone and bones, Cell movement, Cytoskeletal proteins, Evolution, molecular, Female, Homozygote, Humans, Male, Mutation, Phenotype, Phylogeny, Rac GTP-binding proteins, Rac1 GTP-binding protein

وصف الملف: application/pdf

العلاقة: 108S420; K030-T439; 2011K120020; Makale - Uluslararası Hakemli Dergi; American Journal of Human Genetics; Yurt içi; Yurt dışı; Sanayi; Çetinkaya, A. vd. (2016). "Loss-of-function mutations in ELMO2 cause intraosseous vascular malformation by impeding RAC1 signaling". American Journal of Human Genetics, 99(2), 299-317.; https://doi.org/10.1016/j.ajhg.2016.06.008Test; https://www.sciencedirect.com/science/article/pii/S0002929716302105Test; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4974086Test/; http://hdl.handle.net/11452/29550Test; 000381617200004; 2-s2.0-84979752469; 299; 317; 99

الإتاحة: https://doi.org/10.1016/j.ajhg.2016.06.008Test
http://hdl.handle.net/11452/29550Test
https://www.sciencedirect.com/science/article/pii/S0002929716302105Test
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4974086Test/

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النص الكامل

5

The focal adhesion protein Integrin-Linked Kinase (ILK) as an important player in breast cancer pathogenesis

المؤلفون: Katerina Tsirtsaki, Vasiliki Gkretsi

المصدر: Cell Adhesion & Migration
article-version (VoR) Version of Record
Cell Adhesion & Migration, Vol 14, Iss 1, Pp 204-213 (2020)

مصطلحات موضوعية: 0301 basic medicine, Epithelial-Mesenchymal Transition, Breast Neoplasms, Review, Protein Serine-Threonine Kinases, Rictor, Metastasis, Focal adhesion, Pathogenesis, 03 medical and health sciences, Cellular and Molecular Neuroscience, Breast cancer, 0302 clinical medicine, PINCH-1, Cell Line, Tumor, metastasis, Animals, Humans, Medicine, Integrin-linked kinase, lcsh:QH573-671, Protein kinase B, Tissue homeostasis, Focal Adhesions, biology, lcsh:Cytology, business.industry, Akt, EMT, Cancer, Cell Biology, invasion, medicine.disease, 030104 developmental biology, 030220 oncology & carcinogenesis, embryonic structures, PARVA, Neoplastic Stem Cells, biology.protein, Cancer research, Female, ILK, business

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::247e177068705245e6c84da383a27bf6Test
https://doi.org/10.1080/19336918.2020.1829263Test

6

Disruption of the integrin-linked kinase (ILK) pseudokinase domain affects kidney development in mice

المؤلفون: Nada Bulus, Charles R. Sanders, Ambra Pozzi, Glenda Mernaugh, Anika Böttcher, Xinyu Dong, Reinhard Fässler, Roy Zent, Kyle L. Brown

المصدر: Journal of Biological Chemistry
The Journal of Biological Chemistry
J. Biol. Chem. 296:100361 (2021)

مصطلحات موضوعية: IPP, ILK–pinch–parvin, Male, CD, collecting duct, Kidney development, Kidney, Cell morphology, Biochemistry, Mice, 0302 clinical medicine, Mice, Knockout, 0303 health sciences, biology, medicine.diagnostic_test, Chemistry, Microfilament Proteins, PBS, paxillin-binding site, LIM Domain Proteins, MD, molecular dynamics, ILK, integrin-linked kinase, Cell biology, Pleckstrin homology domain, embryonic structures, Female, Research Article, PH, pleckstrin homology, DMEM, Dulbecco's minimal essential media, Molecular Dynamics Simulation, Protein Serine-Threonine Kinases, Cell Line, 03 medical and health sciences, Protein Domains, Western blot, Cell Adhesion, medicine, Animals, Integrin-linked kinase, Cell adhesion, Molecular Biology, Adaptor Proteins, Signal Transducing, 030304 developmental biology, cell culture, Focal Adhesions, western blot, molecular modeling, Membrane Proteins, PC, principal component, Cell Biology, molecular dynamics, Mice, Inbred C57BL, Cell culture, biology.protein, Paxillin, 030217 neurology & neurosurgery

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad61ae4ef7134c8112c643b4b35e5fccTest

7

Integrin-linked kinase controls retinal angiogenesis and is linked to Wnt signaling and exudative vitreoretinopathy

المؤلفون: Kee-Pyo Kim, Wolfgang Berger, Ralf H. Adams, Kenichi Kanai, Hongryeol Park, Lea Ambühl, Hiroyuki Yamamoto, Harald J. Junge, Alessia Fraccaroli, Inga Schmidt, Lucas Mohn, Eloi Montanez, Silke Feil

المساهمون: University of Zurich, Adams, Ralf H

المصدر: Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
Dipòsit Digital de la UB
Universidad de Barcelona
Nature Communications, 10 (1)
Nature Communications

مصطلحات موضوعية: Male, 0301 basic medicine, Integrins, Angiogenesis, Familial Exudative Vitreoretinopathies, General Physics and Astronomy, Neovascularization, 11124 Institute of Medical Molecular Genetics, Mice, chemistry.chemical_compound, 0302 clinical medicine, Protein kinases, Blood-Retinal Barrier, lcsh:Science, Vascular diseases, Wnt Signaling Pathway, Multidisciplinary, Kinase, Microfilament Proteins, Wnt signaling pathway, 3100 General Physics and Astronomy, Metabolisme, Retinal diseases, 3. Good health, Cell biology, Phenotype, Malalties de la retina, 030220 oncology & carcinogenesis, embryonic structures, Female, medicine.symptom, Cèl·lules, Cells, Science, Neovascularization, Physiologic, 610 Medicine & health, 1600 General Chemistry, Protein Serine-Threonine Kinases, Biology, Article, General Biochemistry, Genetics and Molecular Biology, Gene product, 10127 Institute of Evolutionary Biology and Environmental Studies, 03 medical and health sciences, 1300 General Biochemistry, Genetics and Molecular Biology, Human Umbilical Vein Endothelial Cells, medicine, Genetics, Animals, Humans, Integrin-linked kinase, Endothelial Cells, Retinal Vessels, Retinal, General Chemistry, medicine.disease, Proteïnes quinases, 030104 developmental biology, Metabolism, chemistry, biology.protein, Familial exudative vitreoretinopathy, 570 Life sciences, biology, lcsh:Q, Genètica