Genetic risk variants in African Americans with multiple sclerosis
| العنوان: | Genetic risk variants in African Americans with multiple sclerosis |
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| المؤلفون: | Marcelo J. Pando, Stephen L. Hauser, Sooyoung Yang, Laura Piccio, Stephen R. Spellman, Pouya Khankhanian, Stacy J. Caillier, Martin Maiers, Hanne F. Harbo, Pierre-Antoine Gourraud, Anne H. Cross, Philip L. De Jager, Nezih Cereb, Jorge R. Oksenberg, Noriko Isobe, Bruce A.C. Cree, Adam Santaniello |
| المصدر: | Neurology, vol 81, iss 3 Isobe, N; Gourraud, PA; Harbo, HF; Caillier, SJ; Santaniello, A; Khankhanian, P; et al.(2013). Genetic risk variants in African Americans with multiple sclerosis. Neurology, 81(3), 219-227. doi: 10.1212/WNL.0b013e31829bfe2f. UCSF: Retrieved from: http://www.escholarship.org/uc/item/3818f49xTest |
| سنة النشر: | 2013 |
| مصطلحات موضوعية: | Adult, Male, Multiple Sclerosis, Genotype, Clinical Sciences, Single-nucleotide polymorphism, Ancestry-informative marker, Human leukocyte antigen, Neurodegenerative, Biology, Autoimmune Disease, Polymorphism, Single Nucleotide, Article, Clinical Research, Polymorphism (computer science), Genetics, 2.1 Biological and endogenous factors, HLA-DQ beta-Chains, Humans, Genetic Predisposition to Disease, Aetiology, Allele, Polymorphism, Age of Onset, Genotyping, Alleles, Genetic Association Studies, African Americans, Neurology & Neurosurgery, HLA-A Antigens, Human Genome, Neurosciences, Odds ratio, Single Nucleotide, Middle Aged, Brain Disorders, Black or African American, Case-Control Studies, Cognitive Sciences, Female, Neurology (clinical), HLA-DRB1 Chains |
| الوصف: | Objectives: To assess the association of established multiple sclerosis (MS) risk variants in 3,254 African Americans (1,162 cases and 2,092 controls). Methods: Human leukocyte antigen (HLA)-DRB1, HLA-DQB1, and HLA-A alleles were typed by molecular techniques. Single nucleotide polymorphism (SNP) genotyping was conducted for 76 MS-associated SNPs and 52 ancestry informative marker SNPs selected throughout the genome. Self-declared ancestry was refined by principal component analysis of the ancestry informative marker SNPs. An ancestry-adjusted multivariate model was applied to assess genetic associations. Results: The following major histocompatibility complex risk alleles were replicated: HLADRB1 15:01 (odds ratio [OR] 5 2.02 [95% confidence interval: 1.54-2.63], p 5 2.50e-07), HLA-DRB1 03:01 (OR 5 1.58 [1.29-1.94], p 5 1.11e-05), as well as HLA-DRB1 04:05 (OR 5 2.35 [1.26-4.37], p 5 0.007) and the African-specific risk allele of HLA-DRB1 15:03 (OR 5 1.26 [1.05-1.51], p 5 0.012). The protective association of HLA-A02:01 was confirmed (OR 5 0.72 [0.55-0.93], p 5 0.013). None of the HLA-DQB1 alleles were associated with MS. Using a significance threshold of p , 0.01, outside the major histocompatibility complex region, 8MS SNPs were also found to be associated with MS in African Americans. Conclusion: MS genetic risk in African Americans only partially overlaps with that of Europeans and could explain the difference of MS prevalence between populations. © 2013 American Academy of Neurology. |
| وصف الملف: | application/pdf |
| تدمد: | 1526-632X |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e60aa32ec2715f5126af3b290b57cdfTest https://pubmed.ncbi.nlm.nih.gov/23771490Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....6e60aa32ec2715f5126af3b290b57cdf |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 1526632X |
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