Association of Soluble Suppression of Tumorigenesis-2 (ST2) with Endothelial Function in Patients with Ischemic Heart Failure
| العنوان: | Association of Soluble Suppression of Tumorigenesis-2 (ST2) with Endothelial Function in Patients with Ischemic Heart Failure |
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| المؤلفون: | Vasiliki Chara Mystakidi, Nikolaos Gouliopoulos, Manolis Vavuranakis, Costas Tsioufis, Gerasimos Siasos, Dimitris Tousoulis, Vasiliki Tsigkou, Dimitris Athanasiou, Georgios Charalambous, Aimilios Kalampogias, Evangelos Oikonomou, Stathis Dimitropoulos, Evanthia Bletsa |
| المصدر: | International Journal of Molecular Sciences International Journal of Molecular Sciences, Vol 21, Iss 9385, p 9385 (2020) Volume 21 Issue 24 |
| بيانات النشر: | MDPI AG, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | Male, medicine.medical_specialty, Endothelium, Myocardial Ischemia, Pulse Wave Analysis, 030204 cardiovascular system & hematology, Article, Catalysis, lcsh:Chemistry, FMD, Inorganic Chemistry, 03 medical and health sciences, Vascular Stiffness, 0302 clinical medicine, endothelial function, Internal medicine, soluble suppression of tumorigenesis-2, medicine, Humans, 030212 general & internal medicine, Physical and Theoretical Chemistry, Endothelial dysfunction, lcsh:QH301-705.5, Molecular Biology, Pulse wave velocity, Spectroscopy, Aged, Heart Failure, Ejection fraction, business.industry, Organic Chemistry, General Medicine, Middle Aged, medicine.disease, Interleukin-1 Receptor-Like 1 Protein, Pathophysiology, Computer Science Applications, medicine.anatomical_structure, lcsh:Biology (General), lcsh:QD1-999, Heart failure, cardiovascular system, Etiology, Cardiology, Arterial stiffness, Female, Endothelium, Vascular, business, Biomarkers |
| الوصف: | Soluble suppression of tumorigenesis-2 (sST2) has been introduced as a marker associated with heart failure (HF) pathophysiology and status. Endothelial dysfunction is a component underlying HF pathophysiology. Therefore, we examined the association of arterial wall properties with sST2 levels in patients with HF of ischemic etiology. We enrolled 143 patients with stable HF of ischemic etiology and reduced left ventricular ejection fraction (LVEF) and 77 control subjects. Flow-mediated dilation (FMD) was used to evaluate endothelial function and pulse wave velocity (PWV) to assess arterial stiffness. Although there was no significant difference in baseline demographic characteristics, levels of sST2 were increased in HF compared to the control (15.8 (11.0, 21.8) ng/mL vs. 12.5 (10.4, 16.3) ng/mL p < 0.001). In the HF group, there was a positive correlation of sST2 levels with age (rho = 0.22 p = 0.007) while there was no association of LVEF with sST2 (rho = &minus 0.119 p = 0.17) nor with PWV (rho = 0.1 p = 0.23). Interestingly, sST2 was increased in NYHA III [20.0 (12.3, 25.7) ng/mL] compared to patients with NYHA II (15.0 (10.4, 18.2) ng/mL p = 0.003) and inversely associated with FMD (rho = &minus 0.44 0.001) even after adjustment for possible confounders. In patients with chronic HF of ischemic etiology, sST2 levels are increased and are associated with functional capacity. There is an inverse association between FMD and sST2 levels, highlighting the interplay between the dysfunctional endothelium and HF pathophysiologic mechanisms. |
| وصف الملف: | application/pdf |
| تدمد: | 1422-0067 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a85c646a2f815f37b85e3a5d25065deTest https://doi.org/10.3390/ijms21249385Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....2a85c646a2f815f37b85e3a5d25065de |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14220067 |
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