المؤلفون: Napoli, Eleonora, Flores, Amanda, Mansuri, Yasmeen, Hagerman, Randi J, Giulivi, Cecilia

مصطلحات موضوعية: Biological Sciences, Biomedical and Clinical Sciences, Genetics, Fragile X Syndrome, Nutrition, Complementary and Integrative Health, Pediatric, Rare Diseases, Neurodegenerative, Intellectual and Developmental Disabilities (IDD), Clinical Research, Neurosciences, Brain Disorders, Aetiology, 2.1 Biological and endogenous factors, Neurological, Good Health and Well Being, Aged, Aged, 80 and over, Ataxia, Energy Metabolism, Female, Fibroblasts, Humans, In Vitro Techniques, Iron, Isothiocyanates, Male, Middle Aged, Mitochondria, NF-E2-Related Factor 2, Oxidative Stress, Proteasome Endopeptidase Complex, Sulfoxides, Tremor, Unfolded Protein Response, Neurodegeneration, Triplet nucleotide repeat diseases, Bioenergetics, Brain, Antioxidants, Unfolded protein response, NRF2, Phytochemicals, Clinical Sciences, Neurology & Neurosurgery, Biochemistry and cell biology

الوصول الحر: https://escholarship.org/uc/item/99m292mwTest

المؤلفون: Xia, Zhiyu, Su, Yu‐Ru, Petersen, Paneen, Qi, Lihong, Kim, Andre E, Figueiredo, Jane C, Lin, Yi, Nan, Hongmei, Sakoda, Lori C, Albanes, Demetrius, Berndt, Sonja I, Bézieau, Stéphane, Bien, Stephanie, Buchanan, Daniel D, Casey, Graham, Chan, Andrew T, Conti, David V, Drew, David A, Gallinger, Steven J, Gauderman, W James, Giles, Graham G, Gruber, Stephen B, Gunter, Marc J, Hoffmeister, Michael, Jenkins, Mark A, Joshi, Amit D, Le Marchand, Loic, Lewinger, Juan P, Li, Li, Lindor, Noralane M, Moreno, Victor, Murphy, Neil, Nassir, Rami, Newcomb, Polly A, Ogino, Shuji, Rennert, Gad, Song, Mingyang, Wang, Xiaoliang, Wolk, Alicja, Woods, Michael O, Brenner, Hermann, White, Emily, Slattery, Martha L, Giovannucci, Edward L, Chang‐Claude, Jenny, Pharoah, Paul DP, Hsu, Li, Campbell, Peter T, Peters, Ulrike

المصدر: Cancer Medicine. 9(10)

مصطلحات موضوعية: Biomedical and Clinical Sciences, Oncology and Carcinogenesis, Digestive Diseases, Human Genome, Genetics, Cancer, Diabetes, Prevention, Nutrition, Colo-Rectal Cancer, Metabolic and endocrine, ATPases Associated with Diverse Cellular Activities, Aged, Body Mass Index, Colorectal Neoplasms, Databases, Genetic, Diabetes Mellitus, Type 2, Female, Gene Expression, Genotype, Hepatocyte Nuclear Factor 3-alpha, Humans, Male, Microtubule-Associated Proteins, Middle Aged, Obesity, Phenotype, Proteasome Endopeptidase Complex, Protein Tyrosine Phosphatase, Non-Receptor Type 2, Sex Factors, Sialic Acid Binding Ig-like Lectin 3, Voltage-Gated Sodium Channel beta-1 Subunit, BMI, colorectal cancer, diabetes, gene expression, gene-environmental interaction, Biochemistry and Cell Biology, Oncology and carcinogenesis

وصف الملف: application/pdf

الوصول الحر: https://escholarship.org/uc/item/86q5m86bTest

المؤلفون: Banerjee, Sourav, Wei, Tiantian, Wang, Jue, Lee, Jenna J, Gutierrez, Haydee L, Chapman, Owen, Wiley, Sandra E, Mayfield, Joshua E, Tandon, Vasudha, Juarez, Edwin F, Chavez, Lukas, Liang, Ruqi, Sah, Robert L, Costello, Caitlin, Mesirov, Jill P, de la Vega, Laureano, Cooper, Kimberly L, Dixon, Jack E, Xiao, Junyu, Lei, Xiaoguang

المصدر: Proceedings of the National Academy of Sciences of the United States of America. 116(49)

مصطلحات موضوعية: Human Genome, Orphan Drug, Cancer, Genetics, Breast Cancer, Rare Diseases, 5.1 Pharmaceuticals, Development of treatments and therapeutic interventions, ATPases Associated with Diverse Cellular Activities, Animals, Bortezomib, Cell Line, Tumor, Female, Gene Editing, Gene Expression Regulation, Gene Knockout Techniques, HEK293 Cells, Humans, Mice, Inbred BALB C, Mice, Inbred C57BL, Multiple Myeloma, Neoplastic Processes, Phosphorylation, Proteasome Endopeptidase Complex, Proteasome Inhibitors, Protein Serine-Threonine Kinases, Protein-Tyrosine Kinases, TYK2 Kinase, Triple Negative Breast Neoplasms, DYRK, multiple myeloma, triple-negative breast cancer, kinase inhibitor, proteasome inhibitor

وصف الملف: application/pdf

الوصول الحر: https://escholarship.org/uc/item/10h2v4tzTest

المؤلفون: O'Donoghue, Anthony J, Bibo-Verdugo, Betsaida, Miyamoto, Yukiko, Wang, Steven C, Yang, Justin Z, Zuill, Douglas E, Matsuka, Shoun, Jiang, Zhenze, Almaliti, Jehad, Caffrey, Conor R, Gerwick, William H, Eckmann, Lars

المصدر: Antimicrobial Agents and Chemotherapy. 63(11)

مصطلحات موضوعية: Biochemistry and Cell Biology, Biomedical and Clinical Sciences, Biological Sciences, Infectious Diseases, Sexually Transmitted Infections, Biotechnology, 5.1 Pharmaceuticals, Development of treatments and therapeutic interventions, Infection, Good Health and Well Being, Amino Acid Sequence, Animals, Anti-Infective Agents, Antitrichomonal Agents, Cytoplasm, Drug Resistance, Female, Humans, Mice, Mice, Inbred BALB C, Parasitic Sensitivity Tests, Proteasome Endopeptidase Complex, Proteomics, Sexually Transmitted Diseases, Trichomonas Infections, Trichomonas Vaginitis, Trichomonas vaginalis, proteasome, protozoa, Trichomonas vaginalis, Microbiology, Medical Microbiology, Pharmacology and Pharmaceutical Sciences, Medical microbiology, Pharmacology and pharmaceutical sciences

وصف الملف: application/pdf

الوصول الحر: https://escholarship.org/uc/item/2bk3t711Test

المؤلفون: Jalovecka, Marie, Hartmann, David, Miyamoto, Yukiko, Eckmann, Lars, Hajdusek, Ondrej, O'Donoghue, Anthony J, Sojka, Daniel

المصدر: International Journal for Parasitology Drugs and Drug Resistance. 8(3)

مصطلحات موضوعية: Microbiology, Biological Sciences, Rare Diseases, Orphan Drug, Emerging Infectious Diseases, Vector-Borne Diseases, Biotechnology, Malaria, Infectious Diseases, 5.1 Pharmaceuticals, Development of treatments and therapeutic interventions, Infection, Good Health and Well Being, Animals, Babesia, Babesia microti, Babesiosis, Boronic Acids, Cell Line, Disease Models, Animal, Drug Delivery Systems, Female, Macrophages, Mice, Oligopeptides, Proteasome Endopeptidase Complex, Proteasome Inhibitors, Proteome, Proteasome, Carfilzomib, Epoxyketone, Cytotoxicity, Medical Microbiology

وصف الملف: application/pdf

الوصول الحر: https://escholarship.org/uc/item/6rv665g4Test

المؤلفون: Banerjee, Sourav, Ji, Chenggong, Mayfield, Joshua E, Goel, Apollina, Xiao, Junyu, Dixon, Jack E, Guo, Xing

المصدر: Proceedings of the National Academy of Sciences of the United States of America. 115(32)

مصطلحات موضوعية: Complementary and Integrative Health, Cancer, Breast Cancer, 5.1 Pharmaceuticals, Development of treatments and therapeutic interventions, Animals, Antineoplastic Agents, Apoptosis, CRISPR-Cas Systems, Cell Proliferation, Crystallography, X-Ray, Curcumin, Drug Synergism, Female, Gene Editing, Gene Knockout Techniques, HEK293 Cells, Humans, Inhibitory Concentration 50, Mice, Neoplasms, Oligopeptides, Proteasome Endopeptidase Complex, Proteasome Inhibitors, Protein Serine-Threonine Kinases, Protein-Tyrosine Kinases, Signal Transduction, Tumor Burden, Xenograft Model Antitumor Assays, triple-negative breast cancer, multiple myeloma, proteasome inhibitor, kinase specificity profiling, DYRK

وصف الملف: application/pdf

الوصول الحر: https://escholarship.org/uc/item/8g81x53qTest

المؤلفون: Yang, N, Wang, Y, Dai, P, Li, T, Zierhut, C, Tan, A, Zhang, T, Xiang, JZ, Ordureau, A, Funabiki, H, Chen, Z, Deng, L

المساهمون: Zierhut, Christian

مصطلحات موضوعية: Mice, Inbred C57BL, Animals, Knockout, Female, Nucleotidyltransferases, Dendritic Cells, Vaccinia virus, Virulence Factors, Ubiquitination, Viral Proteins, Proteasome Endopeptidase Complex, Interferon Type I, HEK293 Cells, Humans, Membrane Proteins, T-Lymphocytes

جغرافية الموضوع: England

وصف الملف: Electronic; application/pdf

العلاقة: 2898; Nature Communications, 2023, 14 (1), pp. 2898 -; https://repository.icr.ac.uk/handle/internal/5939Test

الإتاحة: https://doi.org/10.1038/s41467-023-38514-5Test
https://repository.icr.ac.uk/handle/internal/5939Test

المؤلفون: Hodonsky, Chani J, Jain, Deepti, Schick, Ursula M, Morrison, Jean V, Brown, Lisa, McHugh, Caitlin P, Schurmann, Claudia, Chen, Diane D, Liu, Yong Mei, Auer, Paul L, Laurie, Cecilia A, Taylor, Kent D, Browning, Brian L, Li, Yun, Papanicolaou, George, Rotter, Jerome I, Kurita, Ryo, Nakamura, Yukio, Browning, Sharon R, Loos, Ruth JF, North, Kari E, Laurie, Cathy C, Thornton, Timothy A, Pankratz, Nathan, Bauer, Daniel E, Sofer, Tamar, Reiner, Alex P

المصدر: PLoS genetics. 13(4)

مصطلحات موضوعية: Erythrocytes, Humans, Proteasome Endopeptidase Complex, Hemoglobins, Homeodomain Proteins, Tumor Suppressor Proteins, Erythrocyte Count, Polymorphism, Single Nucleotide, Hispanic Americans, Female, Male, Genome-Wide Association Study, alpha-Globins, beta-Globins, RNA, Long Noncoding, Solute Carrier Family 12, Member 2, Polymorphism, Single Nucleotide, RNA, Long Noncoding, Solute Carrier Family 12, Member 2, Genetics, Developmental Biology

وصف الملف: application/pdf

الوصول الحر: https://escholarship.org/uc/item/9nh785sgTest

المؤلفون: Küry, Sébastien, Besnard, Thomas, Ebstein, Frédéric, Khan, Tahir N, Gambin, Tomasz, Douglas, Jessica, Bacino, Carlos A, Craigen, William J, Sanders, Stephan J, Lehmann, Andrea, Latypova, Xénia, Khan, Kamal, Pacault, Mathilde, Sacharow, Stephanie, Glaser, Kimberly, Bieth, Eric, Perrin-Sabourin, Laurence, Jacquemont, Marie-Line, Cho, Megan T, Roeder, Elizabeth, Denommé-Pichon, Anne-Sophie, Monaghan, Kristin G, Yuan, Bo, Xia, Fan, Simon, Sylvain, Bonneau, Dominique, Parent, Philippe, Gilbert-Dussardier, Brigitte, Odent, Sylvie, Toutain, Annick, Pasquier, Laurent, Barbouth, Deborah, Shaw, Chad A, Patel, Ankita, Smith, Janice L, Bi, Weimin, Schmitt, Sébastien, Deb, Wallid, Nizon, Mathilde, Mercier, Sandra, Vincent, Marie, Rooryck, Caroline, Malan, Valérie, Briceño, Ignacio, Gómez, Alberto, Nugent, Kimberly M, Gibson, James B, Cogné, Benjamin, Lupski, James R, Stessman, Holly AF, Eichler, Evan E, Retterer, Kyle, Yang, Yaping, Redon, Richard, Katsanis, Nicholas, Rosenfeld, Jill A, Kloetzel, Peter-Michael, Golzio, Christelle, Bézieau, Stéphane, Stankiewicz, Paweł, Isidor, Bertrand

المصدر: American Journal of Human Genetics. 100(2)

مصطلحات موضوعية: Biochemistry and Cell Biology, Bioinformatics and Computational Biology, Biological Sciences, Neurosciences, Congenital Structural Anomalies, Dental/Oral and Craniofacial Disease, Biotechnology, Genetics, Intellectual and Developmental Disabilities (IDD), Human Genome, Pediatric, Brain Disorders, 2.1 Biological and endogenous factors, Aetiology, Adolescent, Animals, Child, Child, Preschool, DNA Copy Number Variations, Disease Models, Animal, Down-Regulation, Female, Gene Deletion, Humans, Infant, Intellectual Disability, Male, Microcephaly, Neurodevelopmental Disorders, Polymorphism, Single Nucleotide, Proteasome Endopeptidase Complex, Zebrafish, PSMD12, RPN5, intellectual disability, proteasome 26S, syndromic neurodevelopmental disorder, ubiquitin, Medical and Health Sciences, Genetics & Heredity, Biological sciences, Biomedical and clinical sciences, Health sciences

وصف الملف: application/pdf

الوصول الحر: https://escholarship.org/uc/item/4s2493nhTest

المؤلفون: Kratter, Ian H, Zahed, Hengameh, Lau, Alice, Tsvetkov, Andrey S, Daub, Aaron C, Weiberth, Kurt F, Gu, Xiaofeng, Saudou, Frédéric, Humbert, Sandrine, Yang, X William, Osmand, Alex, Steffan, Joan S, Masliah, Eliezer, Finkbeiner, Steven

المصدر: Journal of Clinical Investigation. 126(9)

مصطلحات موضوعية: Biochemistry and Cell Biology, Biomedical and Clinical Sciences, Biological Sciences, Huntington's Disease, Orphan Drug, Neurodegenerative, Rare Diseases, Brain Disorders, Neurosciences, 5.1 Pharmaceuticals, 2.1 Biological and endogenous factors, Aetiology, Development of treatments and therapeutic interventions, Neurological, Alanine, Animals, Aspartic Acid, Behavior, Animal, Chromosomes, Artificial, Bacterial, Disease Models, Animal, Disease Progression, Female, Gait, Genotype, Humans, Huntingtin Protein, Huntington Disease, Male, Maze Learning, Mice, Mice, Transgenic, Mutation, Nerve Tissue Proteins, Neurodegenerative Diseases, Neurons, Nuclear Proteins, Phenotype, Phosphorylation, Proteasome Endopeptidase Complex, Serine, Medical and Health Sciences, Immunology, Biological sciences, Biomedical and clinical sciences, Health sciences

وصف الملف: application/pdf

الوصول الحر: https://escholarship.org/uc/item/0k72s7hcTest