المؤلفون: Juan Antonio Navarro, Cristina Rosell-Valle, Antonio J. López-Gambero, Carlos Sanjuan, Patricia Rivera, Antonio Vargas, Juan Suárez, Dina Medina-Vera, Fernando Rodríguez de Fonseca

المساهمون: [López-Gambero,AJ, Rosell-Valle,C, Medina-Vera,D, Navarro,JA, Vargas,A, Rivera,P, Rodríguez de Fonseca,F, Suárez,J] Instituto de investigación Biomédica de Málaga-IBIMA, Málaga, Spain. [López-Gambero,AJ, Rodríguez de Fonseca,F] UGC Salud Mental, Hospital Regional Universitario de Málaga, Málaga, Spain. [López-Gambero,AJ, Medina-Vera,D] Departamento de Biología Celular, Genética y Fisiología, Universidad de Málaga, Andalucia Tech, Málaga, Spain. [Medina-Vera,D, Suárez,J] Facultad de Medicina, Universidad de Málaga, Andalucia Tech, Málaga, Spain. [Medina-Vera,D] UGC Corazón, Hospital Universitario Virgen de la Victoria, Málaga, Spain. [Sanjuan,C] EURONUTRA S.L, Parque Tecnológico de Andalucía, Campanillas, Spain. [Suárez,J] Departamento de Anatomía Humana, Medicina Legal e Historia de la Ciencia, Universidad de Málaga, Málaga, Spain, This research was funded by the European Regional Development Funds-European Union (ERDF-EU) and Fatzheimer project EULAC-HEALTH H2020, grant number EULACH16/T010131, Ministerio de Economía, Industria y Competitividad, Gobierno de España, grant number RTC-2016-4983-1, EU-ERDF and Instituto de Salud Carlos III (ISCIII), grant numbers PI19/01577 and PI19/00343, Ministerio de Sanidad, Delegación de Gobierno para el Plan Nacional sobre Drogas, grant numbers 2019/040 and 2020/048, Consejería de Transformación Económica, Industria, Conocimiento y Universidades, Junta de Andalucía, grant number P18-TP-5194. J.S. (CPII17/00024) holds a 'Miguel Servet II' research contract from the National System of Health, EU-ERDF-ISCIII. P.R. (CP19/00068) holds a 'Miguel Servet I' research contract from the National System of Health, EU-ERDF-ISCIII. D.M-V. (FI20/00227) holds a 'PFIS' predoctoral contract from the National System of Health, EU-ERDF-ISCIII. A.J.L.-G. (IFI18/00042) holds an 'iPFIS' predoctoral contract from the National System of Health, EU-ERDF-ISCIII.

المصدر: International Journal of Molecular Sciences
Volume 22
Issue 10
International Journal of Molecular Sciences, Vol 22, Iss 5365, p 5365 (2021)

مصطلحات موضوعية: Male, Leptin, medicine.medical_treatment, Plaque, Amyloid, Mice, 0302 clinical medicine, Polipéptido inhibidor gástrico, energy expenditure, Organisms::Eukaryota::Animals [Medical Subject Headings], Insulin, Resistin, Organisms::Eukaryota::Animals::Animal Population Groups::Animals, Genetically Modified::Mice, Transgenic [Medical Subject Headings], Biology (General), hypothalamus, Metabolismo energético, Spectroscopy, Enfermedades neuroinflamatorias, digestive, oral, and skin physiology, Chemicals and Drugs::Amino Acids, Peptides, and Proteins::Proteins::Amyloid::Amyloidogenic Proteins [Medical Subject Headings], Brain, General Medicine, 5xFAD, Chemicals and Drugs::Amino Acids, Peptides, and Proteins::Peptides::Peptide Hormones::Pancreatic Hormones::Insulins [Medical Subject Headings], Ghrelin, Amyloid, medicine.medical_specialty, QH301-705.5, Chemicals and Drugs::Amino Acids, Peptides, and Proteins::Peptides::Intercellular Signaling Peptides and Proteins::Cytokines::Interleukins::Interleukin-1 [Medical Subject Headings], Hypothalamus, Check Tags::Male [Medical Subject Headings], Resistencia a la insulina, Chemicals and Drugs::Hormones, Hormone Substitutes, and Hormone Antagonists::Hormones::Peptide Hormones::Adipokines::Resistin [Medical Subject Headings], Article, Inorganic Chemistry, 03 medical and health sciences, Diseases::Nutritional and Metabolic Diseases::Metabolic Diseases::Glucose Metabolism Disorders::Hyperinsulinism::Insulin Resistance [Medical Subject Headings], Leptina, Alzheimer Disease, Diseases::Pathological Conditions, Signs and Symptoms::Pathological Conditions, Anatomical::Plaque, Amyloid [Medical Subject Headings], Ghrelina, Molecular Biology, Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Rodentia::Muridae::Murinae::Mice [Medical Subject Headings], Chemicals and Drugs::Hormones, Hormone Substitutes, and Hormone Antagonists::Hormones::Gastrointestinal Hormones::Gastric Inhibitory Polypeptide [Medical Subject Headings], Chemicals and Drugs::Amino Acids, Peptides, and Proteins::Peptides::Amyloid beta-Peptides [Medical Subject Headings], Body weight, Diseases::Nutritional and Metabolic Diseases::Metabolic Diseases [Medical Subject Headings], medicine.disease, Orexin, Chemicals and Drugs::Amino Acids, Peptides, and Proteins::Proteins::Amyloid::Amyloidogenic Proteins::Amyloid beta-Protein Precursor [Medical Subject Headings], 030104 developmental biology, Endocrinology, Resistina, Check Tags::Female [Medical Subject Headings], Chemicals and Drugs::Enzymes and Coenzymes::Enzymes::Transferases::Phosphotransferases::Phosphotransferases (Alcohol Group Acceptor)::Protein Kinases::Protein-Serine-Threonine Kinases::TOR Serine-Threonine Kinases [Medical Subject Headings], 030217 neurology & neurosurgery, 0301 basic medicine, Chemicals and Drugs::Amino Acids, Peptides, and Proteins::Proteins::Amyloid [Medical Subject Headings], Orexinas, neuroinflammation, Amyloid beta-Protein Precursor, Neuroinflammation, Glucagon-Like Peptide 1, Enfermedad de Alzheimer, Phenomena and Processes::Digestive System and Oral Physiological Phenomena::Digestive System Physiological Phenomena::Digestive System Processes::Eating [Medical Subject Headings], Gastric inhibitory polypeptide, Chemicals and Drugs::Amino Acids, Peptides, and Proteins::Peptides::Intercellular Signaling Peptides and Proteins::Agouti-Related Protein [Medical Subject Headings], Chemicals and Drugs::Hormones, Hormone Substitutes, and Hormone Antagonists::Hormones::Gastrointestinal Hormones::Proglucagon::Glucagon-Like Peptides::Glucagon-Like Peptide 1 [Medical Subject Headings], Chemicals and Drugs::Enzymes and Coenzymes::Enzymes::Transferases::Phosphotransferases::Phosphotransferases (Alcohol Group Acceptor)::Protein Kinases::Protein-Serine-Threonine Kinases::AMP-Activated Protein Kinases [Medical Subject Headings], Computer Science Applications, Insulin signaling, Chemistry, Female, Factor de transcripción STAT5, Alzheimer’s disease, hormones, hormone substitutes, and hormone antagonists, Diseases::Nervous System Diseases::Neurodegenerative Diseases::Tauopathies::Alzheimer Disease [Medical Subject Headings], Amyloidogenic Proteins, Mice, Transgenic, Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Models, Animal::Disease Models, Animal [Medical Subject Headings], Gastric Inhibitory Polypeptide, Catalysis, Proteínas sustrato del receptor de insulina, Insulin resistance, Metabolic Diseases, Internal medicine, medicine, Animals, Physical and Theoretical Chemistry, QD1-999, insulin signaling, Chemicals and Drugs::Hormones, Hormone Substitutes, and Hormone Antagonists::Hormones::Peptide Hormones::Adipokines::Leptin [Medical Subject Headings], Amyloid beta-Peptides, business.industry, Organic Chemistry, Peso corporal, Phenomena and Processes::Metabolic Phenomena::Metabolism::Energy Metabolism [Medical Subject Headings], Anatomy::Nervous System::Central Nervous System::Brain [Medical Subject Headings], Chemicals and Drugs::Amino Acids, Peptides, and Proteins::Peptides::Intracellular Signaling Peptides and Proteins::Adaptor Proteins, Signal Transducing::STAT Transcription Factors [Medical Subject Headings], Anatomy::Nervous System::Central Nervous System::Brain::Limbic System::Hypothalamus [Medical Subject Headings], STAT5 transcription factor, IRS1, Disease Models, Animal, Chemicals and Drugs::Hormones, Hormone Substitutes, and Hormone Antagonists::Hormones::Peptide Hormones::Ghrelin [Medical Subject Headings], Diseases::Pathological Conditions, Signs and Symptoms::Signs and Symptoms::Body Weight [Medical Subject Headings], Energy expenditure, Energy Metabolism, business, Hipotálamo

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المؤلفون: Theresa E. Bjorness, Robert W. Greene

المصدر: Pharmacol Biochem Behav

مصطلحات موضوعية: Male, Sleep Wake Disorders, Adenosine, media_common.quotation_subject, Dopamine, Clinical Biochemistry, Self Administration, Toxicology, Biochemistry, Article, Arousal, 03 medical and health sciences, Behavioral Neuroscience, Cocaine-Related Disorders, 0302 clinical medicine, Cocaine, Dopamine Uptake Inhibitors, Reward, medicine, Animals, Humans, Biological Psychiatry, media_common, Pharmacology, Sleep disorder, Orexins, Behavior, Animal, business.industry, Abstinence, medicine.disease, Sleep in non-human animals, 030227 psychiatry, Orexin, Sleep behavior, Cocaine use, Conditioning, Operant, Female, business, Sleep, Neuroscience, 030217 neurology & neurosurgery, medicine.drug

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المؤلفون: Nancy Bower, Takashi Ueno, Carsten T. Beuckmann, Shoji Asakura, Margaret Moline, Motohiro Shiotani, Atsushi Fujiwara, David V. Gauvin

المصدر: Regulatory Toxicology and Pharmacology. 127:105053

مصطلحات موضوعية: Male, Zolpidem, Pyridines, Substance-Related Disorders, Lemborexant, Physical dependence, Stimulus (physiology), Pharmacology, Toxicology, medicine, Animals, Hypnotics and Sedatives, Dose-Response Relationship, Drug, business.industry, Suvorexant, Antagonist, General Medicine, Orexin receptor, Rats, Substance Withdrawal Syndrome, Pyrimidines, Female, Orexin Receptor Antagonists, medicine.symptom, Self-administration, business, medicine.drug

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المؤلفون: Manuel Sanchez-Alavez, Cindy L. Ehlers, Derek N. Wills, Leslie R. Amodeo

المصدر: Alcohol Clin Exp Res

مصطلحات موضوعية: medicine.medical_specialty, Rapid eye movement sleep, 030508 substance abuse, Medicine (miscellaneous), Binge drinking, Sleep, REM, Underage Drinking, Toxicology, Sleep, Slow-Wave, Article, Binge Drinking, 03 medical and health sciences, 0302 clinical medicine, Orexin Receptors, Internal medicine, Sleep Initiation and Maintenance Disorders, Insomnia, medicine, Animals, Theta Rhythm, Wakefulness, Slow-wave sleep, Ethanol, business.industry, Antagonist, Central Nervous System Depressants, Electroencephalography, Sleep in non-human animals, Brain Waves, Orexin receptor, Orexin, Rats, Psychiatry and Mental health, Disease Models, Animal, Endocrinology, Delta Rhythm, Sleep Deprivation, Female, Orexin Receptor Antagonists, medicine.symptom, 0305 other medical science, business, Sleep, 030217 neurology & neurosurgery

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المؤلفون: Eric F P M Vuurman, Johannes G Ramaekers, Cees J Van Leeuwen, Anita C M Van Oers, Oneeb Majid, Ishani Landry, Carlos Perdomo, Kate Pinner, Gleb Filippov, Margaret Moline, Patricia Murphy, Stefan Jongen, Annemiek Vermeeren

المصدر: Sleep

مصطلحات موضوعية: Adult, Male, Automobile Driving, plasma concentrations, Pyridines, hypnotics, elderly, Piperazines, Young Adult, Double-Blind Method, Physiology (medical), driving, adults, Humans, Hypnotics and Sedatives, AcademicSubjects/MED00385, Driving Under the Influence, Aged, Cross-Over Studies, AcademicSubjects/SCI01870, Middle Aged, Healthy Volunteers, Pyrimidines, Insomnia and Psychiatric Disorders, orexin antagonist, Female, Orexin Receptor Antagonists, zopiclone, Neurology (clinical), Erratum, Azabicyclo Compounds, Psychomotor Performance, AcademicSubjects/MED00370, lemborexant

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المؤلفون: Clemens Muehlan, Racheal Rowles, Pierre Peeters, Rob Zuiker, Jasper Dingemanse

المصدر: Journal of clinical psychopharmacology. 40(2)

مصطلحات موضوعية: Adult, Male, medicine.medical_specialty, media_common.quotation_subject, Placebo, Gastroenterology, White People, 03 medical and health sciences, 0302 clinical medicine, Pharmacokinetics, Asian People, Internal medicine, medicine, Humans, Pharmacology (medical), Adverse effect, media_common, business.industry, Area under the curve, Middle Aged, Orexin receptor, 030227 psychiatry, Psychiatry and Mental health, Pharmacodynamics, Female, Orexin Receptor Antagonists, medicine.symptom, business, 030217 neurology & neurosurgery, Somnolence, Vigilance (psychology)

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المؤلفون: Brandon S. Bentzley, Morgan H. James, Linnea R. Freeman, Gary Aston-Jones

المصدر: International Journal of Neuropsychopharmacology

مصطلحات موضوعية: Male, medicine.medical_specialty, SB334867, AcademicSubjects/MED00415, Hypocretin, behavioral economics, Biology, Body weight, Regular Research Articles, Rats, Sprague-Dawley, Eating, Binge-eating disorder, Internal medicine, Male rats, medicine, High fat, Animals, Urea, Pharmacology (medical), Naphthyridines, Pharmacology, Benzoxazoles, Motivation, Orexins, Sex Characteristics, Behavior, Animal, Economic demand, AcademicSubjects/SCI01870, Economics, Behavioral, digestive, oral, and skin physiology, sucrose, Feeding Behavior, medicine.disease, Orexin, Rats, Sexual dimorphism, Psychiatry and Mental health, Eating disorders, Endocrinology, high-fat food, Female, Orexin Receptor Antagonists

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المؤلفون: Sara E. Keefer, Lauren C. Anderson, Sindy Cole, Gorica D. Petrovich

المصدر: J Neurosci

مصطلحات موضوعية: Male, Lateral hypothalamus, media_common.quotation_subject, Prefrontal Cortex, Biology, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Orexin Receptors, Neuroplasticity, Neural Pathways, Animals, Learning, Prefrontal cortex, Neurotransmitter, Sensory cue, Research Articles, 030304 developmental biology, media_common, Neurons, 0303 health sciences, Neuronal Plasticity, General Neuroscience, digestive, oral, and skin physiology, Appetite, Feeding Behavior, Associative learning, Orexin, Rats, chemistry, nervous system, Hypothalamic Area, Lateral, Female, Cues, Neuroscience, 030217 neurology & neurosurgery, psychological phenomena and processes, Signal Transduction

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المؤلفون: Sergio Bernardini, Marzia Nuccetelli, Nicola Biagio Mercuri, Francesca Izzi, Simona Di Santo, Matteo Spanetta, Giulia Maria Sancesario, Fabio Placidi, Claudio Liguori, Flaminia Franchini

المصدر: Journal of Alzheimer's disease : JAD. 74(2)

مصطلحات موضوعية: 0301 basic medicine, Oncology, cognition, Male, medicine.medical_specialty, Alzheimer’s disease, orexin, sleep-wake cycle, tau proteins, tau Proteins, Disease, Neuropsychological Tests, 03 medical and health sciences, 0302 clinical medicine, Alzheimer Disease, Sleep Disorders, Circadian Rhythm, Internal medicine, Insomnia, Medicine, Dementia, Humans, Circadian rhythm, Wakefulness, Aged, Orexins, business.industry, General Neuroscience, Settore BIO/12, Cognition, General Medicine, Middle Aged, medicine.disease, Mental Status and Dementia Tests, Sleep in non-human animals, Actigraphy, Orexin, Psychiatry and Mental health, Clinical Psychology, 030104 developmental biology, Tauopathies, Sleep Deprivation, Sleep diary, Female, Geriatrics and Gerontology, medicine.symptom, business, Sleep, psychological phenomena and processes, 030217 neurology & neurosurgery

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المؤلفون: Nancy Hall, Ishani Landry, Jagadeesh Aluri, Bojan Lalovic, Jim Ferry, Kenya Nakai, Margaret Moline

المصدر: Clinical Pharmacology in Drug Development

مصطلحات موضوعية: Adult, Male, safety, Pyridines, media_common.quotation_subject, insomnia, orexin receptor antagonists, Lemborexant, Pharmaceutical Science, Original Manuscript, Pharmacology, 030226 pharmacology & pharmacy, White People, 03 medical and health sciences, 0302 clinical medicine, Sex Factors, Pharmacokinetics, Asian People, Double-Blind Method, Insomnia, pharmacodynamics, Medicine, Humans, Pharmacology (medical), media_common, Aged, Dose-Response Relationship, Drug, business.industry, Antagonist, Age Factors, Wake time, Articles, Middle Aged, Orexin receptor, Pyrimidines, 030220 oncology & carcinogenesis, Pharmacodynamics, Female, medicine.symptom, business, pharmacokinetics, Vigilance (psychology), Half-Life, lemborexant

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