المؤلفون: Gustavo Nunes de Oliveira Costa, Mittermayer Barreto Santiago, Emanuela Pimenta da Fonseca, Carolina Freitas Lins, Willer Gonçalves Dourado Santos, Lúcio Macedo Barbosa, Viviane Machicado, Daniel Sá Ribeiro, Carla Baleeiro Rodrigues Silva, Giselle Calasans de Souza Costa, Mitermayer G. Reis, Maria Eduarda Haerdy Monteiro, Verena Galvão, Anna Paula Mota Duque Sousa, Maria Fernanda Rios Grassi, Ana Luisa Pedreira, Mauricio Lima Barreto

المصدر: JCR: Journal of Clinical Rheumatology. 27:S193-S197

مصطلحات موضوعية: Adult, Male, medicine.medical_specialty, Population, Pilot Projects, Human leukocyte antigen, Polymorphism, Single Nucleotide, Jaccoud arthropathy, Rheumatology, immune system diseases, Internal medicine, Arthropathy, Humans, Lupus Erythematosus, Systemic, Medicine, Genetic Predisposition to Disease, In patient, skin and connective tissue diseases, education, Allele frequency, education.field_of_study, Lupus erythematosus, business.industry, Case-control study, Middle Aged, medicine.disease, Dermatology, Case-Control Studies, Interferon Regulatory Factors, Immunology, Female, Joint Diseases, business, Serositis

الوصف: Introduction Jaccoud arthropathy (JA) is a nonerosive and deforming arthropathy experienced frequently by patients with systemic lupus erythematosus (SLE). Although genetic polymorphisms are associated with SLE development, the association between genetic polymorphisms and JA has not been studied to date. The main objective of this study was to evaluate an association between HLA, STAT4, IRF5, and BLK polymorphisms and the presence of JA in Brazilian individuals with SLE. Methods Patients were selected from a cohort of individuals with SLE followed at 2 rheumatology reference centers in Salvador, Bahia, Brazil. The JA diagnosis was based on clinical and radiological criteria. The participants were genotyped for rs9271100, rs7574865, rs10488631, and rs13277113 polymorphisms in the HLA, STAT4, IRF5, and BLK genes, respectively, using real-time polymerase chain reaction. The presence of JA was correlated with allele frequencies, and clinical and laboratory data. Results One hundred forty-four individuals with SLE (38 with JA and 106 with SLE without JA) were studied. The mean age of the patients was 45 ± 12 years; the majority were women and had brown skin. Patients with JA had a longer disease duration than patients without JA. Serositis and neuropsychiatric manifestations were more frequent in the JA population. The A allele of rs13277113 in the BLK gene was associated with the presence of JA. Conclusions The rs13277113 polymorphism in the BLK gene was found to be a possible genetic risk for JA development. However, further studies in larger populations should be performed to confirm this finding.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cbb61c645992176aada8bacf3145cc66Test
https://doi.org/10.1097/rhu.0000000000001653Test

المؤلفون: Felicidade Mota Pereira, Roberto Perez Carreiro, Bernardo Galvão Castro, Luciano Kalabric Silva, Maria Fernanda Rios Grassi, Fred Luciano Neves Santos, Maria da Conceição Almeida Chagas

المصدر: The American Journal of Tropical Medicine and Hygiene

مصطلحات موضوعية: Adult, Male, Veterinary medicine, Hepatitis C virus, Population, Hepacivirus, Biology, medicine.disease_cause, Article, Serology, Interquartile range, Seroepidemiologic Studies, Virology, Genotype, medicine, Seroprevalence, Humans, education, Genotyping, Retrospective Studies, education.field_of_study, virus diseases, Hepatitis C, Middle Aged, medicine.disease, digestive system diseases, Infectious Diseases, Parasitology, Female, Brazil

الوصف: In Salvador, which is the capital of the Brazilian state of Bahia, it has been estimated that 1.5% of the general population is infected with hepatitis C virus (HCV); however, the circulation of HCV throughout the state remains unknown. The present retrospective study aimed to determine anti-HCV seroprevalence and describe the geographic distribution of hepatitis C in Bahia. Data from HCV serological tests submitted to the Bahia Central Laboratory of Public Health between 2004 and 2013 were analyzed. Serology for HCV was performed using the AxSYM anti-HCV enzymatic microparticle immunoassay and chemiluminescence immunoassay. A subgroup of samples with detectable HCV-RNA was genotyped using the linear array hepatitis C virus genotyping assay. A total of 247,837 samples were analyzed. The median age of the studied population was 31 years (interquartile range, 25–44 years), and the female:male ratio was 3.9:1. The global seroprevalence of HCV in Bahia was estimated to be 1.3% (3,230/247,837), corresponding to an infection rate of 21.2/100,000 inhabitants. The seroprevalence of HCV was higher among males and increased with age. The presence of anti-HCV antibodies was detected throughout all mesoregions of Bahia, and the municipality with the highest infection rate was Ipiaú (112.04 cases/100,000 inhabitants). Genotypes 1 and 3 were found to be the most prevalent, followed by genotypes 2, 4, and 5. Our results provide evidence of the widespread distribution of previous HCV infection throughout the state of Bahia.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc5d38c7367670e2705defb87127574dTest
http://europepmc.org/articles/PMC8592152Test

المؤلفون: Junji Yamauchi, Kenichiro Tanabe, Tomoo Sato, Masanori Nakagawa, Eiji Matsuura, Yoshio Tsuboi, Keiko Tamaki, Hirokuni Sakima, Satoshi Ishihara, Yuki Ohta, Naoki Matsumoto, Kenichi Kono, Naoko Yagishita, Natsumi Araya, Katsunori Takahashi, Yasuo Kunitomo, Misako Nagasaka, Ariella Coler-Reilly, Yasuhiro Hasegawa, Abelardo Araujo, Steven Jacobson, Maria Fernanda Rios Grassi, Bernardo Galvão-Castro, Martin Bland, Graham P. Taylor, Fabiola Martin, Yoshihisa Yamano

المصدر: Viruses, Vol 14, Iss 136, p 136 (2022)
Viruses
Viruses; Volume 14; Issue 1; Pages: 136

مصطلحات موضوعية: Male, Human T-lymphotropic virus 1, Motor Disorders, prednisolone, Middle Aged, Microbiology, Article, Paraparesis, Tropical Spastic, human T-lymphotropic virus type 1, methylprednisolone, QR1-502, Infectious Diseases, Treatment Outcome, Adrenal Cortex Hormones, Virology, randomized controlled trial, Humans, Disabled Persons, Female, Prospective Studies, HTLV-1-associated myelopathy, Aged

الوصف: Corticosteroids are most commonly used to treat HTLV-1-associated myelopathy (HAM); however, their clinical efficacy has not been tested in randomized clinical trials. This randomized controlled trial included 8 and 30 HAM patients with rapidly and slowly progressing walking disabilities, respectively. Rapid progressors were assigned (1:1) to receive or not receive a 3-day course of intravenous methylprednisolone in addition to oral prednisolone therapy. Meanwhile, slow progressors were assigned (1:1) to receive oral prednisolone or placebo. The primary outcomes were a composite of ≥1-grade improvement in the Osame Motor Disability Score or ≥30% improvement in the 10 m walking time (10 mWT) at week 2 for rapid progressors and changes from baseline in 10 mWT at week 24 for slow progressors. In the rapid progressor trial, all four patients with but only one of four without intravenous methylprednisolone achieved the primary outcome (p = 0.14). In the slow progressor trial, the median changes in 10 mWT were −13.8% (95% CI: −20.1–−7.1; p < 0.001) and −6.0% (95% CI: −12.8–1.3; p = 0.10) with prednisolone and placebo, respectively (p for between-group difference = 0.12). Whereas statistical significance was not reached for the primary endpoints, the overall data indicated the benefit of corticosteroid therapy. (Registration number: UMIN000023798, UMIN000024085)

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e4481974ca3f88ee2a15d5ab3e18037Test
https://www.mdpi.com/1999-4915/14/1/136Test

المؤلفون: Ângelo Antônio Oliveira Silva, Leonardo Maia Leony, Wayner Vieira de Souza, Natália Erdens Maron Freitas, Ramona Tavares Daltro, Emily Ferreira Santos, Larissa de Carvalho Medrado Vasconcelos, Maria Fernanda Rios Grassi, Carlos Gustavo Regis-Silva, Fred Luciano Neves Santos

المصدر: PloS one. 17(10)

مصطلحات موضوعية: Multidisciplinary, Pregnancy, Syphilis, Congenital, Infant, Newborn, Humans, Female, Pregnant Women, Syphilis, Pregnancy Complications, Infectious, Brazil, Retrospective Studies

الوصف: In Brazil, the notification of congenital (CS) and syphilis in pregnant women (SiP) is compulsory. Notification data provided by the Ministry of Health in combination with the mapping of vulnerable geographic areas is essential to forecasting possible outbreaks and more effectively combating infection through monitoring. We aim to evaluate the spatiotemporal distribution and epidemiological aspects of reported cases of CS and SiP in Brazil. A retrospective ecological study was carried out using secondary surveillance data obtained from the Brazilian National Notifiable Diseases Information System (SINAN) database, considering all reported cases of CS and SiP between 2001 to 2017. Epidemiological characteristics and time trends were analyzed using joinpoint regression models and spatial distribution, considering microregions or states/macroregions as units of analysis. A total of 188,630 (359/100,000 birth lives) CS and 235,895 of SiP (6.3/100,000 inhabitants) were reported during the period studied. In general, the epidemiologic profile of Brazil indicates most reported CS cases occurred in "mixed-race" newborns who were diagnosed within seven days of birth and whose mothers had received prenatal care, but the epidemiologic profile varies by Brazilian macroregion. Regarding SiP, most cases were among women who self-reported ‘mixed-race’, were aged 20–39 years, had up to eight years of formal education and were diagnosed with primary or latent syphilis. Approximately 549 (98.4%) and 558 (100%) microregions reported at least one case of CS and SiP, respectively. From 2012 to 2016, CS cases increased significantly in almost all Brazilian states, most notably in the South, Southeast, and Central-West macroregions, from 2001–2017 and the relative risk (RR) of SiP increased around 400% (RR: 1,00 to 445,50). Considering the epidemiological scenario of the infection in Brazil, it is necessary to enhance preventive, control and eradication measures.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eadfcec8d8d749fec8b428c020ab4b48Test
https://pubmed.ncbi.nlm.nih.gov/36201505Test

المؤلفون: Hans Yssel, Aurélien Corneau, Luana Leandro Gois, Christopher Maucourant, Catherine Blanc, Maria Fernanda Rios Grassi, Nadine Tarantino, Aïda Meghraoui-Kheddar, Vincent Vieillard, Assia Samri, Antonio Bandeira, Gabriel Andrade Nonato Queiroz

المساهمون: Centre d'Immunologie et de Maladies Infectieuses (CIMI), Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Cytométrie Pitié-Salpêtrière (PASS-CYPS), Unité Mixte de Service Production et Analyse de données en Sciences de la vie et en Santé (PASS), Sorbonne Université (SU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU)-Institut National de la Santé et de la Recherche Médicale (INSERM), Sorbonne Université (SU)-Institut National de la Santé et de la Recherche Médicale (INSERM)

المصدر: Journal of Immunology
Journal of Immunology, Publisher : Baltimore : Williams & Wilkins, c1950-. Latest Publisher : Bethesda, MD : American Association of Immunologists, 2021, 207 (5), pp.1333-1343. ⟨10.4049/jimmunol.2001180⟩

مصطلحات موضوعية: medicine.medical_treatment, [SDV]Life Sciences [q-bio], Immunology, Cell, Lymphocyte Activation, Zika virus, Cohort Studies, Interferon-gamma, 03 medical and health sciences, 0302 clinical medicine, Immune system, Pregnancy, MHC class I, STAT5 Transcription Factor, medicine, Humans, Immunology and Allergy, Mass cytometry, Cells, Cultured, ComputingMilieux_MISCELLANEOUS, 030304 developmental biology, 0303 health sciences, biology, Tumor Necrosis Factor-alpha, Zika Virus Infection, Receptors, KIR3DL1, Zika Virus, biology.organism_classification, Interleukin-12, 3. Good health, Killer Cells, Natural, Flavivirus, Cytokine, medicine.anatomical_structure, Acute Disease, biology.protein, Female, KIR3DL1, 030215 immunology

الوصف: Zika virus (ZIKV) is a mosquito-borne flavivirus that has emerged as a global concern because of its impact on human health. ZIKV infection during pregnancy can cause microcephaly and other severe brain defects in the developing fetus and there have been reports of the occurrence of Guillain-Barré syndrome in areas affected by ZIKV. NK cells are activated during acute viral infections and their activity contributes to a first line of defense because of their ability to rapidly recognize and kill virus-infected cells. To provide insight into NK cell function during ZIKV infection, we have profiled, using mass cytometry, the NK cell receptor-ligand repertoire in a cohort of acute ZIKV-infected female patients. Freshly isolated NK cells from these patients contained distinct, activated, and terminally differentiated, subsets expressing higher levels of CD57, NKG2C, and KIR3DL1 as compared with those from healthy donors. Moreover, KIR3DL1+ NK cells from these patients produced high levels of IFN-γ and TNF-α, in the absence of direct cytotoxicity, in response to in vitro stimulation with autologous, ZIKV-infected, monocyte-derived dendritic cells. In ZIKV-infected patients, overproduction of IFN-γ correlated with STAT-5 activation (r = 0.6643; p = 0.0085) and was mediated following the recognition of MHC class 1–related chain A and chain B molecules expressed by ZIKV-infected monocyte-derived dendritic cells, in synergy with IL-12 production by the latter cells. Together, these findings suggest that NK cells contribute to the generation of an efficacious adaptive anti-ZIKV immune response that could potentially affect the outcome of the disease and/or the development of persistent symptoms.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db5d75fe68fe719df4371b6278b29f3bTest
https://hal.archives-ouvertes.fr/hal-03382710Test

المؤلفون: Raphaela Lisboa Andrade, Vincent Vieillard, Maria Fernanda Rios Grassi, Rita Elizabeth Moreira Mascarenhas, Bernardo Galvão-Castro, Gabriel Andrade Nonato Queiroz

المساهمون: Gestionnaire, Hal Sorbonne Université, Fundação Oswaldo Cruz (FIOCRUZ), Réseau International des Instituts Pasteur (RIIP), Centre d'Immunologie et des Maladies Infectieuses (CIMI), Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Sorbonne Université (SU), Escola Bahiana de Medicina e Saúde Pública, Centre d'Immunologie et de Maladies Infectieuses (CIMI)

المصدر: BMC Infectious Diseases, Vol 19, Iss 1, Pp 1-9 (2019)
BMC Infectious Diseases
BMC Infectious Diseases, 2019, 19 (1), pp.433. ⟨10.1186/s12879-019-4032-1⟩
BMC Infectious Diseases, BioMed Central, 2019, 19 (1), pp.433. ⟨10.1186/s12879-019-4032-1⟩

مصطلحات موضوعية: Male, NK cells, [SDV.IMM.II]Life Sciences [q-bio]/Immunology/Innate immunity, Granzymes, 0302 clinical medicine, [SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases, immune system diseases, Tropical spastic paraparesis, Medicine, Cytotoxic T cell, NKp30, 0303 health sciences, medicine.diagnostic_test, biology, Degranulation, Antibodies, Monoclonal, virus diseases, Middle Aged, Flow Cytometry, Paraparesis, Tropical Spastic, 3. Good health, Killer Cells, Natural, Infectious Diseases, CD107, [SDV.MHEP.MI] Life Sciences [q-bio]/Human health and pathology/Infectious diseases, Female, Research Article, Adult, Natural cytotoxicity receptor, Flow cytometry, lcsh:Infectious and parasitic diseases, 03 medical and health sciences, Interferon-gamma, Humans, lcsh:RC109-216, [SDV.IMM.II] Life Sciences [q-bio]/Immunology/Innate immunity, 030304 developmental biology, Innate immune system, Natural Cytotoxicity Triggering Receptor 3, business.industry, Perforin, NKG2D, medicine.disease, HTLV-I Infections, Granzyme B, Cross-Sectional Studies, HTLV-1, Immunology, biology.protein, business, K562 Cells, HAM/TSP, 030217 neurology & neurosurgery, Biomarkers

الوصف: International audience; BACKGROUND: Natural killer (NK) cells are part of the innate immune system and provide surveillance against viruses and cancers. The ability of NK cells to kill virus-infected cells depends on the balance between the effects of inhibitory and activating NK cell receptors. This study aimed to investigate the phenotypic profile and the functional capacity of NK cells in the context of HTLV-1 infection.METHODS: This cross-sectional study sequentially recruited HTLV-1 infected individuals with HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP) and asymptomatic HTLV-1 (AS) from the Integrated and Multidisciplinary HTLV Center in Salvador, Brazil. Blood samples from healthy blood donors served as controls. NK cell surface receptors (NKG2D, KIR2DL2/KIR2DL3, NKp30, NKG2A, NKp46, TIM-3 and PD-1), intracellular cytolytic (Granzyme B, perforin) and functional markers (CD107a for degranulation, IFN-γ) were assayed by flow cytometry in the presence or absence of standard K562 target cells. In addition, cytotoxicity assays were performed in the presence or absence of anti-NKp30.RESULTS: The frequency of NKp30+ NK cells was significantly decreased in HAM/TSP patients [58%, Interquartile Range (IQR) 30-61] compared to controls (73%, IQR 54-79, p = 0.04). The production of cytolytic (perforin, granzyme B) and functional markers (CD107a and IFN-γ) was higher in unstimulated NK cells from HAM/TSP and AS patients compared to controls. By contrast, stimulation with K562 target cells did not alter the frequency of CD107a+ NK cells in HAM/TSP subjects compared to the other groups. Blockage of the NKp30 receptor was shown to decrease cytotoxic activity (CD107a) and IFN-γ expression only in asymptomatic HTLV-1-infected individuals.CONCLUSIONS: NK cells from individuals with a diagnosis of HAM/TSP present decreased expression of the activating receptor NKp30, in addition to elevated degranulation activity that remained unaffected after blocking the NKp30 receptor.

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a6dad214f4360323ce5518190f40269aTest
http://link.springer.com/article/10.1186/s12879-019-4032-1Test

المؤلفون: Maria Fernanda Rios Grassi, Úrsula Cury Copello, Bernardo Galvão-Castro, Thessika Hialla Almeida Araujo, Regina Helena Rathsam-Pinheiro, Karla Tayrine Silva Guimarães Rios, Ney Boa-Sorte

المصدر: Brazilian Journal of Infectious Diseases, Vol 23, Iss 2, Pp 95-101 (2019)
Brazilian Journal of Infectious Diseases v.23 n.2 2019
Brazilian Journal of Infectious Diseases
Brazilian Society of Infectious Diseases (BSID)
instacron:BSID
Brazilian Journal of Infectious Diseases, Volume: 23, Issue: 2, Pages: 101-95, Published: 18 JUL 2019

مصطلحات موضوعية: Male, Visual acuity, Prevalence, lcsh:QR1-502, lcsh:Microbiology, Myelopathy, Tropical spastic paraparesis, Human T cell lymphotropic virus type 1, Poisson Distribution, Child, Aged, 80 and over, Human T-lymphotropic virus 1, Reverse Transcriptase Polymerase Chain Reaction, Age Factors, Middle Aged, Viral Load, Infectious Diseases, Child, Preschool, symbols, Female, medicine.symptom, Brazil, Microbiology (medical), Adult, medicine.medical_specialty, Adolescent, Keratoconjunctivitis Sicca, Enzyme-Linked Immunosorbent Assay, Dry eye syndromes, lcsh:Infectious and parasitic diseases, symbols.namesake, Young Adult, Age Distribution, Sex Factors, Internal medicine, medicine, Humans, lcsh:RC109-216, Poisson regression, Aged, business.industry, Keratoconjunctivitis sicca, medicine.disease, Confidence interval, eye diseases, Cross-Sectional Studies, Socioeconomic Factors, HTLV-1, DNA, Viral, Itching, business

الوصف: Background: The prevalence of keratoconjunctivitis sicca (KCS) associated with Human T-Cell Lymphotropic Virus Type 1 (HTLV-1) (HTLV-1/KCS) has been estimated at around 37%, but its clinical manifestations are poorly described. Purpose: To determine the prevalence and associated factors of HTLV-1/KCS in a large cohort of HTLV-1-infected individuals living in Salvador, Brazil. Methods: A cross-sectional study was conducted between June 2004 and September 2017 at the Integrative and Multidisciplinary Center for HTLV in Salvador, Bahia-Brazil. Data from 758 HTLV-1-infected patients was collected. A complete ophthalmologic examination was performed in both eyes. Lacrimal function was evaluated by breakup time, Rose Bengal and Schirmer I Tests. KCS diagnosis was considered in the presence of at least two out of three positive tests. HTLV-1 proviral load Crude and Adjusted Prevalence Rates (PR) with 95% Confidence Intervals (95% CI) were estimated using multivariate Poisson Regression with robust error variance. Results: The overall prevalence of KCS was 31.7%, with higher rates observed in HTLV-1-associated myelopathy/tropical spastic paraparesis patients (crude PR: 1.84; CI95%: 1.50–2.26) even after adjusting for age, sex, time of HTLV-1 diagnosis and schooling (adjusted PR: 1.63; CI95%: 1.31–2.02). Proviral load, low corrected visual acuity, burning and/or pain and itching were all significantly higher in patients with KCS. Conclusion: Burning and/or pain and itching and low corrected visual acuity were the most common alterations of HTLV-1/KCS. High Proviral load was found to be associated with the presence of KCS. It is strongly recommended that HTLV-1 patients undergo periodic ophthalmologic examination to promote the early diagnosis of KCS and prevent the consequences associated with dry eye disease. Keywords: HTLV-1, Keratoconjunctivitis sicca, Prevalence, Dry eye syndromes

وصف الملف: text/html

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d5de906bd24aa891c9a3ea483e30a07Test
http://www.sciencedirect.com/science/article/pii/S1413867018311048Test

المؤلفون: Maíara Cerqueira, Ney Boa-Sorte, Thiago de Faria Junqueira, Bernardo Galvão-Castro, Monique Lírio, Humberto Castro-Lima, Sonia Lucia Rangel, André Luís Silva, Maria Fernanda Rios Grassi, Maria Luísa Carvalho Soliani, Ana Karina Galvão-Barroso, Adriele Ribeiro, Thessika Hialla Almeida Araujo, Aidê Nunes, Ana Verena Galvão-Castro, Inês Dourado

المصدر: PLoS Neglected Tropical Diseases
PLoS Neglected Tropical Diseases, Vol 14, Iss 12, p e0008922 (2020)

مصطلحات موضوعية: Male, RNA viruses, Viral Diseases, Pulmonology, Epidemiology, Coronaviruses, Health Care Providers, RC955-962, Telehealth, Pathology and Laboratory Medicine, Geographical locations, White Blood Cells, Medical Conditions, Animal Cells, Arctic medicine. Tropical medicine, Pandemic, Medicine and Health Sciences, Infected population, Allied Health Care Professionals, Human T-lymphotropic virus 1, T Cells, Middle Aged, Telemedicine, Geography, Infectious Diseases, Medical Microbiology, Viral Pathogens, Viruses, Female, Public aspects of medicine, RA1-1270, Pathogens, SARS CoV 2, Cellular Types, Brazil, Adult, 2019-20 coronavirus outbreak, medicine.medical_specialty, Coronavirus disease 2019 (COVID-19), SARS coronavirus, Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), Immune Cells, Immunology, Microbiology, Respiratory Disorders, Retroviruses, medicine, Humans, Pandemics, Microbial Pathogens, Aged, Symposium, Blood Cells, Biology and life sciences, SARS-CoV-2, Public Health, Environmental and Occupational Health, Organisms, COVID-19, Covid 19, Htlv-1, Cell Biology, South America, Virology, HTLV-I Infections, Health Care, Socioeconomic Factors, Respiratory Infections, People and places

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d15afdd495a73e99513deefdc1de32aTest
https://pubmed.ncbi.nlm.nih.gov/33382699Test

المؤلفون: Roberto Perez Carreiro, Fred Luciano Neves Santos, Felicidade Mota Pereira, Bernardo Galvão-Castro, Maria Fernanda Rios Grassi, Maria da Conceição Chagas de Almeida

المصدر: PLoS ONE, Vol 15, Iss 7, p e0223087 (2020)
PLoS ONE

مصطلحات موضوعية: Male, RNA viruses, 0301 basic medicine, Luminescence, Chemiluminescence, Gastroenterology and hepatology, Hepacivirus, Human T-lymphotropic virus, Antibodies, Viral, medicine.disease_cause, Geographical locations, Hepatitis, Serology, Prevalence, Pathology and laboratory medicine, Human T-lymphotropic virus 1, education.field_of_study, Multidisciplinary, biology, Coinfection, Hepatitis C virus, Physics, Electromagnetic Radiation, virus diseases, Hepatitis C, Medical microbiology, Infectious hepatitis, Infectious Diseases, Viruses, Physical Sciences, Medicine, Female, Pathogens, Brazil, Research Article, Adult, Genotype, Science, 030106 microbiology, Population, Sexually Transmitted Diseases, Viral diseases, Microbiology, 03 medical and health sciences, Retroviruses, medicine, Humans, education, Liver diseases, Retrospective Studies, Medicine and health sciences, Biology and life sciences, Flaviviruses, Organisms, Viral pathogens, Htlv-1, Hepatitis C Antibodies, South America, biology.organism_classification, medicine.disease, HTLV-I Infections, Virology, Hepatitis viruses, Microbial pathogens, 030104 developmental biology, Virus type, Co-Infections, People and places, Co infection

الوصف: Both Human T-lymphotropic virus type 1 (HTLV-1) and hepatitis C virus (HCV) are endemic in Brazil. In Salvador, the capital of the state of Bahia, 2% and 1.5% of the general population is infected with HTLV-1 or HCV. This study aimed to estimate the prevalence and the distribution of HTLV/HCV coinfection in Bahia. This cross-sectional study was conducted at the Central Laboratory of Public Health for the state of Bahia (LACEN-BA). All samples in the LACEN database submitted to serological testing for anti-HCV (chemiluminescence) and anti-HTLV-1/2 (chemiluminescence/ELISA and Western blot) from 2004 to 2013 were included. Infection rate was expressed as the number of infected individuals per 100,000 inhabitants in a given municipality; municipalities were grouped by microregion for further analysis. A total of 120,192 samples originating from 358 of the 417 municipalities in Bahia (85.8%) were evaluated. The overall HCV coinfection rate in HTLV-positive was 14.31% [2.8 (ranging from 0.4 to 8.0) per 100,000 inhabitants.] Twenty-one (5%) of the municipalities reported at least one case of HTLV/HCV coinfection. Most cases (87%) were concentrated in three microregions (Salvador: 79%, Ilhéus/Itabuna: 5%, Porto Seguro: 3%). Coinfection occurred more frequently in males (51%) with a mean age of 59 [(IQR): 46 – 59] years. HTLV/HCV coinfection in the state of Bahia was more frequently found among males living in the microregions of Salvador, Ilhéus/Itabuna and Porto Seguro, all of which are known to be endemic for HTLV infection. Keywords: HTLV; HCV; Coinfection; Bahia; Prevalence

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4cf150ffe7bb5f89d0106487607284b4Test

المؤلفون: Everton da Silva Batista, Adenilda Lima Lopes Martins, Alisson de Aquino Firmino, Maria Fernanda Rios Grassi, Taiane Silva Paixão, Luana Leandro Gois, Bernardo Galvão-Castro

المصدر: Brazilian Journal of Infectious Diseases, Volume: 23, Issue: 1, Pages: 27-33, Published: 20 MAY 2019
Brazilian Journal of Infectious Diseases v.23 n.1 2019
Brazilian Journal of Infectious Diseases
Brazilian Society of Infectious Diseases (BSID)
instacron:BSID
Brazilian Journal of Infectious Diseases, Vol 23, Iss 1, Pp 27-33 (2019)

مصطلحات موضوعية: Microbiology (medical), Adult, Proviral load, medicine.medical_treatment, Cervicovaginal cytopathology, lcsh:QR1-502, Enzyme-Linked Immunosorbent Assay, Cervix Uteri, Asymptomatic, lcsh:Microbiology, Virus, Statistics, Nonparametric, lcsh:Infectious and parasitic diseases, Proinflammatory cytokine, 03 medical and health sciences, Immune system, Th2 Cells, medicine, Humans, lcsh:RC109-216, Human T cell lymphotropic virus type 1, 0303 health sciences, Human T-lymphotropic virus 1, 030306 microbiology, business.industry, Interleukin-17, Th1 Cells, Viral Load, Inflammatory cytokines, HTLV-I Infections, Body Fluids, Infectious Diseases, Real-time polymerase chain reaction, Cytokine, Cross-Sectional Studies, Social Class, Cytopathology, HTLV-1, Immunology, Vagina, Leukocytes, Mononuclear, Cytokines, Female, medicine.symptom, business

الوصف: Introduction: Human T-cell lymphotropic virus type 1 (HTLV-1) is sexually transmitted and causes persistent infection. This virus induces activation of the immune system and production of inflammatory cytokines. This study aimed to assess the cytokine profile and cytopathological findings in the cervicovaginal fluid of asymptomatic HTLV-1-infected women. Methods: HTLV-1-infected and uninfected women were selected at the Centro de Atendimento ao Portador de HTLV in Salvador-Brazil. None of the included HTLV-1-infected women reported any HTLV-1-associated diseases. All volunteers underwent gynecological examination to collect cervicovaginal fluid. Cytokine quantification was performed using the Cytometric Bead Array (CBA) Human Th1/Th2/Th17 kit. Light microscopy was used to evaluate cervicovaginal cytopathology. In addition, proviral load in cervicovaginal fluid and peripheral blood was measured by real-time quantitative polymerase chain reaction. Results: 112 women (63 HTLV-1-infected and 49 uninfected) were evaluated. No differences were found with respect to cytopathological cervicovaginal findings between the groups. IL-2, TNF, IL-4, IL-10, and IL-17 levels were significantly higher in cervicovaginal fluid of the HTLV-1-infected women than in uninfected women (p

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