دورية أكاديمية
Assessment of Residual Cancer Burden and Event-Free Survival in Neoadjuvant Treatment for High-risk Breast Cancer: An Analysis of Data From the I-SPY2 Randomized Clinical Trial.
| العنوان: | Assessment of Residual Cancer Burden and Event-Free Survival in Neoadjuvant Treatment for High-risk Breast Cancer: An Analysis of Data From the I-SPY2 Randomized Clinical Trial. |
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| المؤلفون: | Symmans, W Fraser, Yau, Christina, Chen, Yunn-Yi, Balassanian, Ron, Klein, Molly E, Pusztai, Lajos, Nanda, Rita, Parker, Barbara A, Datnow, Brian, Krings, Gregor, Wei, Shi, Feldman, Michael D, Duan, Xiuzhen, Chen, Beiyun, Sattar, Husain, Khazai, Laila, Zeck, Jay C, Sams, Sharon, Mhawech-Fauceglia, Paulette, Rendi, Mara, Sahoo, Sunati, Ocal, Idris Tolgay, Fan, Fang, LeBeau, Lauren Grasso, Vinh, Tuyethoa, Troxell, Megan L, Chien, A Jo, Wallace, Anne M, Forero-Torres, Andres, Ellis, Erin D, Albain, Kathy S, Murthy, Rashmi K, Boughey, Judy C, Liu, Minetta C, Haley, Barbara B, Elias, Anthony D, Clark, Amy S, Kemmer, Kathleen, Isaacs, Claudine, Lang, Julie E, Han, Hyo S, Edmiston, Kirsten, Viscusi, Rebecca K, Northfelt, Donald W, Khan, Qamar J, Leyland-Jones, Brian, Venters, Sara J, Shad, Sonal, Matthews, Jeffrey B, Asare, Smita M, Buxton, Meredith, Asare, Adam L, Rugo, Hope S, Schwab, Richard B, Helsten, Teresa, Hylton, Nola M, van 't Veer, Laura, Perlmutter, Jane, DeMichele, Angela M, Yee, Douglas, Berry, Donald A, Esserman, Laura J |
| المصدر: | Articles, Abstracts, and Reports |
| بيانات النشر: | Providence St. Joseph Health Digital Commons |
| سنة النشر: | 2021 |
| المجموعة: | Providence St. Joseph Health Digital Commons |
| مصطلحات موضوعية: | washington, seattle, swedish, swedish cancer, Adult, Antineoplastic Combined Chemotherapy Protocols, Breast Neoplasms, Female, Humans, Middle Aged, Neoadjuvant Therapy, Neoplasm, Residual, Prognosis, Progression-Free Survival, Receptor, ErbB-2, Oncology |
| الوصف: | IMPORTANCE: Residual cancer burden (RCB) distributions may improve the interpretation of efficacy in neoadjuvant breast cancer trials. OBJECTIVE: To compare RCB distributions between randomized control and investigational treatments within subtypes of breast cancer and explore the relationship with survival. DESIGN, SETTING, AND PARTICIPANTS: The I-SPY2 is a multicenter, platform adaptive, randomized clinical trial in the US that compares, by subtype, investigational agents in combination with chemotherapy vs chemotherapy alone in adult women with stage 2/3 breast cancer at high risk of early recurrence. Investigational treatments graduated in a prespecified subtype if there was 85% or greater predicted probability of higher rate of pathologic complete response (pCR) in a confirmatory, 300-patient, 1:1 randomized, neoadjuvant trial in that subtype. Evaluation of a secondary end point was reported from the 10 investigational agents tested in the I-SPY2 trial from March 200 through 2016, and analyzed as of September 9, 2020. The analysis plan included modeling of RCB within subtypes defined by hormone receptor (HR) and ERBB2 status and compared control treatments with investigational treatments that graduated and those that did not graduate. INTERVENTIONS: Neoadjuvant paclitaxel plus/minus 1 of several investigational agents for 12 weeks, then 12 weeks of cyclophosphamide/doxorubicin chemotherapy followed by surgery. MAIN OUTCOMES AND MEASURES: Residual cancer burden (pathological measure of residual disease) and event-free survival (EFS). RESULTS: A total of 938 women (mean [SD] age, 49 [11] years; 66 [7%] Asian, 103 [11%] Black, and 750 [80%] White individuals) from the first 10 investigational agents were included, with a median follow-up of 52 months (IQR, 29 months). Event-free survival worsened significantly per unit of RCB in every subtype of breast cancer (HR-positive/ERBB2-negative: hazard ratio [HZR], 1.75; 95% CI, 1.45-2.16; HR-positive/ERBB2-positive: HZR, 1.55; 95% CI, 1.18-2.05; ... |
| نوع الوثيقة: | text |
| اللغة: | unknown |
| العلاقة: | https://digitalcommons.psjhealth.org/publications/5930Test; https://pubmed.ncbi.nlm.nih.gov/34529000Test/ |
| الإتاحة: | https://digitalcommons.psjhealth.org/publications/5930Test https://pubmed.ncbi.nlm.nih.gov/34529000Test/ |
| رقم الانضمام: | edsbas.DAE22B2 |
| قاعدة البيانات: | BASE |
| الوصف غير متاح. |