المؤلفون: Lakhbir Kaur Dhaliwal, Virendra Singh, Sunita Kumari, Kartar Singh, Sujata Siwatch

المصدر: Journal of obstetrics and gynaecology : the journal of the Institute of Obstetrics and Gynaecology. 42(5)

مصطلحات موضوعية: Infertility, Liver Cirrhosis, medicine.medical_specialty, Cirrhosis, endocrine system diseases, digestive system, Gastroenterology, Non-alcoholic Fatty Liver Disease, Diabetes mellitus, Internal medicine, medicine, Humans, Risk factor, Transaminases, medicine.diagnostic_test, business.industry, Fatty liver, nutritional and metabolic diseases, Obstetrics and Gynecology, medicine.disease, female genital diseases and pregnancy complications, digestive system diseases, Liver biopsy, Female, Metabolic syndrome, Insulin Resistance, Transient elastography, business, Infertility, Female, Polycystic Ovary Syndrome

الوصف: Non-alcoholic fatty liver disease (NAFLD) is a frequent occurrence in polycystic ovarian syndrome (PCOS). We studied the frequencies and characteristics of NAFLD in PCOS women. We compared various methods of detection of advanced fibrosis/cirrhosis. One hundred and forty women with PCOS and seventy controls, matched for age, were evaluated for the presence of NAFLD. Anthropometric variables, serum levels of aminotransferases, glucose, lipids and transient elastography were done. Thirty-six percent of the NAFLD patients had abnormal aminotransferases. In women presenting to an infertility clinic, NAFLD was higher in both obese and non-obese PCOS women, being present in 117 (83.6%) of PCOS cases and 32 (45.7%) of non-PCOS controls (p< .001). Fibroscan is helpful in evaluating for liver fibrosis in patients with NAFLD.Impact StatementWhat is already known on this subject? Polycystic ovarian syndrome (PCOS) has been associated with many long-term health complications including endometrial cancer, diabetes, hypertension and metabolic syndrome. The association of PCOS with NAFLD has been suggested. NAFLD is recognised as a leading cause of liver dysfunction which can progress to long-term sequel of cirrhosis.What do the results of this study add? In this study, asymptomatic women seeking treatment of infertility were screened for presence of NAFLD. The study shows a high prevalence of NAFLD in young Indian women. The prevalence was significantly higher in women with PCOS than non-PCOS women.What are the implications of these findings for clinical practice and/or further research? The findings of the study suggest that all infertile women, especially those with PCOS, should be screened for NAFLD. This will help in early identification and management of this condition and to avoid long-term consequences of liver dysfunction and cirrhosis. PCOS is an independent risk factor for the development of NAFLD in obese women. Liver ultrasound, serum levels of transaminases clinch the diagnosis. Short of liver biopsy, non-invasive tests like Fibroscan and NAFLD fibrosis score are useful to assess the stage of fibrosis.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::14586b810f18b20d6236cc72d538ab29Test
https://pubmed.ncbi.nlm.nih.gov/34689689Test

المؤلفون: Anupama Hari, Amita Jain, Neena Malhotra, Venkateswaran K. Iyer, S. P. Jaiswar, Lakhbir Kaur Dhaliwal, Urvashi B. Singh, Nomita Chandhiok, Aparna Srikantam, Aijaz Ahmad, Pankush Gupta, Shalini Gainder

المصدر: European journal of obstetrics, gynecology, and reproductive biology. 267

مصطلحات موضوعية: Pathology, medicine.medical_specialty, Tuberculosis, Biopsy, Antitubercular Agents, Endometrium, Immune system, medicine, Humans, Subclinical infection, CD20, medicine.diagnostic_test, biology, business.industry, Obstetrics and Gynecology, Mycobacterium tuberculosis, medicine.disease, Tuberculosis, Female Genital, medicine.anatomical_structure, Reproductive Medicine, Granuloma, biology.protein, Immunohistochemistry, Female, business, Infertility, Female, Endometrial biopsy

الوصف: Background Female Genital Tuberculosis (FGTB) causes infertility in a large number of females in developing countries. Presence of granuloma on histopathological examination of endometrial samples is diagnostic of FGTB. But immunohistochemical evaluation of endometrial aspirates has not been explored before. Aim To evaluate the immunohistochemical delineation of immune cells in FGTB. Methods 1515 infertile women from 20 to 35 years were enrolled and underwent endometrial aspiration (EA), which was subjected to microbiological and histopathological examination along with PCR. Patients positive for conventional tests like granulomas, acid fast bacilli, mycobacterial culture on LJ medium or liquid (MGIT) culture were started on antitubercular therapy. Conventional test negative but PCR positive patients were posted for laparoscopy. Immunohistochemistry (IHC) for LCA, CD68, CD3, CD4, CD8, CD 20, CD138, IFN gamma and IL10 were evaluated. Result 38/1515 (2.5%) subjects tested positive for conventional methods. PCR-TB was positive in 615/1515 samples (40.59%). On IHC, the number of CD45 (LCA) positive immune cells (p = 0.03) and IFN gamma (p = 0.002) and IL10 expression (p = 0.012) at 1 + level were higher in the PCR positive samples. Laparoscopy done in 418/463 patients and 89/418 (21.3%) showed definitive findings of tuberculosis. CD3, CD4, CD8, CD20, CD68 and CD138 showed no correlation with PCR and laparoscopy. Conclusion Increased IFN gamma and IL 10 expressing immune cells in PCR positive EA suggests subclinical early changes, and can be useful as a research tool but have no role in diagnosing FGTB.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4638c8ccf485a356819e3dce353437dbTest
https://pubmed.ncbi.nlm.nih.gov/34800826Test

المؤلفون: Seema, Chopra, Susmita, Sharma, Kusum, Sharma, Nalini, Gupta, Aman, Sharma, Lakhbir Kaur, Dhaliwal, Arvind, Rajvanshi, Meera, Sharma

المصدر: The Journal of the Association of Physicians of India. 67(12)

مصطلحات موضوعية: Antigens, Bacterial, Humans, Tuberculosis, Female, Mycobacterium tuberculosis, Multiplex Polymerase Chain Reaction, Sensitivity and Specificity, Tuberculosis, Female Genital

الوصف: Female genital tract tuberculosis (FGTB) is a very common disease in developing countries. Rapid and specific diagnosis is of paramount importance.To evaluate Multiplex PCR using MPB 64 and IS6110 primers directed against M. tuberculosis for the diagnosis of FGTB and to compare the different methods available for diagnosis like histopathology, smear microscopy and TB culture.Multiplex PCR was performed on endometrial biopsy samples of 21FGTB confirmed cases, 49 clinically suspected FGTB cases and 25 Non TB (control group) patients.: Multiplex PCR had sensitivity of 95.23% for confirmed cases and specificity of 100% for confirmed FGTB cases. In 49 clinically diagnosed, but unconfirmed FGTB cases multiplex PCR was positive in 61.22% cases. The overall sensitivity of microscopy, culture, Histopathology and multiplex PCR were 1.42%, 8.57%, 21.42%, 72.85% and specificity was 100%, 100%, 100% and 100% respectively.Multiplex PCR using MPB 64 and IS6110 primers has a high sensitivity and specificity in diagnosis of FGTB.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=pmid________::7fb51052ceed2c598280c2f9481ebe31Test
https://pubmed.ncbi.nlm.nih.gov/31801325Test

المؤلفون: Lakhbir Kaur Dhaliwal, Shalmoli Bhattacharya, Savita Bhunwal, Kanya Mukhopadhyay, Pranab Dey

المصدر: Indian Pediatrics. 55:211-215

مصطلحات موضوعية: Male, medicine.medical_specialty, Birth weight, Chorioamnionitis, Gastroenterology, Cohort Studies, Sepsis, 03 medical and health sciences, 0302 clinical medicine, Pregnancy, Risk Factors, 030225 pediatrics, Internal medicine, Ductus arteriosus, medicine, Birth Weight, Humans, Rupture of membranes, Bronchopulmonary Dysplasia, 030219 obstetrics & reproductive medicine, business.industry, Infant, Newborn, medicine.disease, medicine.anatomical_structure, Bronchopulmonary dysplasia, Pediatrics, Perinatology and Child Health, Gestation, Female, business, Infant, Premature

الوصف: To find out the incidence and associations of bronchopulmonary dysplasia (BPD) in preterm neonates. Descriptive cohort. All consecutively born neonates

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e17f47af500f9c8c68ba2280d11fb2aTest
https://doi.org/10.1007/s13312-018-1319-zTest

المؤلفون: Neha Mittal, Upasana Gautam, Radhika Srinivasan, Arvind Rajwanshi, Raje Nijhawan, Swati Sood, Nalini Gupta, Lakhbir Kaur Dhaliwal

المصدر: Indian Journal of Pathology and Microbiology, Vol 59, Iss 4, Pp 481-488 (2016)

مصطلحات موضوعية: Microbiology (medical), Adult, Pathology, medicine.medical_specialty, endocrine system diseases, Serous carcinoma, serous tubal intraepithelial carcinoma, lcsh:QR1-502, Context (language use), Biology, Fallopian tube, sectioning and extensively examining the fimbria protocol, lcsh:Microbiology, Pathology and Forensic Medicine, 03 medical and health sciences, Young Adult, 0302 clinical medicine, Fallopian Tube Neoplasm, medicine, lcsh:Pathology, Fallopian Tube Neoplasms, Humans, Prospective Studies, Cystadenocarcinoma, Fallopian Tubes, secretory cell outgrowths, 030219 obstetrics & reproductive medicine, Carcinoma in situ, Serous Tubal Intraepithelial Carcinoma, General Medicine, Middle Aged, medicine.disease, female genital diseases and pregnancy complications, p53 signature, Cystadenocarcinoma, Serous, Serous fluid, medicine.anatomical_structure, serous carcinoma, 030220 oncology & carcinogenesis, Case-Control Studies, Female, Tumor Suppressor Protein p53, Carcinoma in Situ, lcsh:RB1-214

الوصف: Context: High-grade serous carcinomas of ovarian, tubal, and peritoneal origin are together referred as pelvic serous carcinoma. The fallopian tubes, ovarian surface epithelium, and the tuboperitoneal junctional epithelium are all implicated in pelvic serous carcinogenesis. Aims: The aim of this study is to identify putative precursor lesions of serous carcinoma including secretory cell outgrowths (SCOUTs), serous tubal intraepithelial carcinoma (STIC), and p53 signatures and assign its probable site of origin. Settings and Design: Prospective case-control study of consecutive specimen comprising 32 serous carcinomas and 31 controls (10 normal adnexa, 10 benign and 6 atypically proliferative surface epithelial tumors, and 5 other carcinomas). Subjects and Methods: Sectioning and extensive examination of the fimbrial end (SEE-FIM) protocol along with immunohistochemistry for Bcl-2, p53, and Ki-67 was employed for evaluating invasive carcinoma and precursor lesions in cases versus controls. Results: SCOUT, p53 signatures, and STIC were most frequent in the serous carcinomas. p53 signatures and STIC were always seen in the fimbrial end. STICs were exclusively present in serous carcinomas, more common in ipsilateral tubes of cases with dominant ovarian mass. Multifocal p53 signatures with STIC were seen in 7 (21.9%) cases. STIC was present with or without an invasive carcinoma in 25% and in 6.25% of cases of pelvic serous carcinomas, respectively. The junctional epithelia did not show any lesion in any group. Conclusions: SEE-FIM protocol is recommended for evaluation of sporadicpelvic (ovarian/tubal/peritoneal) serous carcinoma. Based on the presence of STIC or invasive carcinoma, nearly 60% of all pelvic serous carcinomas are of fallopian tubal origin.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::90c221bc1ea06f7232a3cccf358b6fdeTest
http://www.ijpmonline.org/article.asp?issn=0377-4929;year=2016;volume=59;issue=4;spage=481;epage=488;aulast=MittalTest

المؤلفون: Sujata Ghosh, Firuza D. Patel, A. Arora, Lakhbir Kaur Dhaliwal, Swati Sood, Radhika Srinivasan

المصدر: Clinical Oncology. 27:720-727

مصطلحات موضوعية: Adult, Uterine Cervical Neoplasms, MLH1, Epigenesis, Genetic, Gene expression, Humans, Medicine, Neoplasm Invasiveness, Radiology, Nuclear Medicine and imaging, Telomerase reverse transcriptase, Epigenetics, Promoter Regions, Genetic, Telomerase, Aged, MyoD Protein, Neoplasm Staging, business.industry, Estrogen Receptor alpha, Promoter, Chemoradiotherapy, Methylation, DNA Methylation, Middle Aged, Prognosis, Gene Expression Regulation, Neoplastic, Oncology, DNA methylation, Cancer research, Female, business

الوصف: Aims Locally advanced invasive cervical cancer [International Federation of Gynecology and Obstetrics (FIGO) IIB/III] is treated by chemoradiation. The response to treatment is variable within a given FIGO stage. Therefore, the aim of the present study was to evaluate the gene promoter methylation profile and corresponding transcript expression of a panel of six genes to identify genes which could predict the response of patients treated by chemoradiation. Materials and methods In total, 100 patients with invasive cervical cancer in FIGO stage IIB/III who underwent chemoradiation treatment were evaluated. Ten patients developed systemic metastases during therapy and were excluded. On the basis of patient follow-up, 69 patients were chemoradiation-sensitive, whereas 21 were chemoradiation-resistant. Gene promoter methylation and gene expression was determined by TaqMan assay and quantitative real-time PCR, respectively, in tissue samples. Results The methylation frequency of ESR1, BRCA1, RASSF1A, MLH1, MYOD1 and hTERT genes ranged from 40 to 70%. Univariate and hierarchical cluster analysis revealed that gene promoter methylation of MYOD1, ESR1 and hTERT could predict for chemoradiation response. A pattern of unmethylated MYOD1, unmethylated ESR1 and methylated hTERT promoter as well as lower ESR1 transcript levels predicted for chemoradiation resistance. Conclusion Methylation profiling of a panel of three genes that includes MYOD1, ESR1 and hTERT may be useful to predict the response of invasive cervical carcinoma patients treated with standard chemoradiation therapy.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7cd8959c3621a78f484a3fb6552d3a4bTest
https://doi.org/10.1016/j.clon.2015.08.001Test

المؤلفون: Naresh Sachdeva, Anil Bhansali, Mahinder Paul, Lakhbir Kaur Dhaliwal, Devi Dayal

المصدر: Cytotherapy. 20(11)

مصطلحات موضوعية: 0301 basic medicine, Adult, CD4-Positive T-Lymphocytes, Cancer Research, Immunology, Cell- and Tissue-Based Therapy, chemical and pharmacologic phenomena, Stimulation, medicine.disease_cause, T-Lymphocytes, Regulatory, Autoimmunity, Umbilical Cord, Cell therapy, Immunomodulation, 03 medical and health sciences, 0302 clinical medicine, Transforming Growth Factor beta, medicine, Immunology and Allergy, Humans, IL-2 receptor, Genetics (clinical), Cells, Cultured, Proinsulin, Transplantation, Chemistry, Infant, Newborn, Interleukin-2 Receptor alpha Subunit, hemic and immune systems, Forkhead Transcription Factors, Cell Biology, Fetal Blood, In vitro, 030104 developmental biology, Diabetes Mellitus, Type 1, Oncology, Cord blood, Female, 030215 immunology, Transforming growth factor

الوصف: Background Antigen-specific regulatory T cells (Tregs) have proven to be effective in reversing established autoimmunity in type 1 diabetes (T1D). Cord blood (CB) can serve as an efficient and safe source for Tregs for antigen-specific immunomodulation in T1D, a strategy that is yet to be explored. Therefore, we assessed the potential of CB in generation of proinsulin (PI)-specific Tregs by using HLA class II tetramers. Methods We analyzed the frequency of PI-specific natural Tregs (nTregs) and induced Tregs (iTregs) derived from the CB as well as peripheral blood (PB) of patients with T1D and healthy control subjects. For this, CD4+CD25+CD127low and CD4+CD25-T cells were cultured in the presence of PI-derived peptides, transforming growth factor (TGF)-β and rapamycin. PI-specific Tregs were then selected using allele-specific HLA II tetramers loaded with PI-derived peptides, followed by suppression assays. Results Following stimulation, we observed that CB harbors a significantly higher frequency of PI-specific Tregs than PB of subjects with T1D (P = 0.0003). Further, the proportion of PI-specific Tregs was significantly higher in both the nTreg (P = 0.01) and iTreg (P = 0.0003) compartments of CB as compared with PB of subjects with T1D. In co-culture experiments, the PI-specific Tregs suppressed the proliferation of effector T cells significantly (P = 0.0006). The expanded nTregs were able to retain hypomethylation status at their Tregs-specific demethylated region (TSDR), whereas iTregs were unable to acquire the characteristic demethylation pattern. Conclusion Our study demonstrates that CB can serve as an excellent source for generation of functional antigen-specific Tregs for immunotherapeutic approaches in subjects with T1D.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b1d1296747742f727c916606f34c638dTest
https://pubmed.ncbi.nlm.nih.gov/30340983Test

المؤلفون: Rashmi Bagga, Sanjeev Sharma, Shifa Javed, Bal Krishan Sharma, Swati Sood, Shalmoli Bhattacharyya, Lakhbir Kaur Dhaliwal, Radhika Srinivasan, Charan Singh Rayat

المصدر: BMC Cancer
BMC Cancer, Vol 18, Iss 1, Pp 1-12 (2018)

مصطلحات موضوعية: 0301 basic medicine, HPV16, Cancer Research, Epithelial-Mesenchymal Transition, Biopsy, Population, Karyotype, Uterine Cervical Neoplasms, Antineoplastic Agents, Minisatellite Repeats, Biology, Low passage, lcsh:RC254-282, Flow cytometry, 03 medical and health sciences, 0302 clinical medicine, Cancer stem cell, Cell Line, Tumor, Genetics, medicine, Humans, Epithelial–mesenchymal transition, AC133 Antigen, CD133, Cell Self Renewal, education, Cervical cancer, education.field_of_study, Human papillomavirus 16, medicine.diagnostic_test, Cancer stem cells, Cell Cycle, Papillomavirus Infections, Cell cycle, lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens, medicine.disease, Flow Cytometry, 030104 developmental biology, Oncology, Cell culture, 030220 oncology & carcinogenesis, Cancer research, Neoplastic Stem Cells, Adenocarcinoma, Cell lines, Female, Cisplatin, Research Article

الوصف: Background Cervical cancer is a major cause of cancer-related mortality in women in the developing world. Cancer Stem cells (CSC) have been implicated in treatment resistance and metastases development; hence understanding their significance is important. Methods Primary culture from tissue biopsies of invasive cervical cancer and serial passaging was performed for establishing cell lines. Variable Number Tandem Repeat (VNTR) assay was performed for comparison of cell lines with their parental tissue. Tumorsphere and Aldefluor assays enabled isolation of cancer stem cells (CSC); immunofluorescence and flow cytometry were performed for their surface phenotypic expression in cell lines and in 28 tissue samples. Quantitative real-time PCR for stemness and epithelial-mesenchymal transition (EMT) markers, MTT cytotoxicity assay, cell cycle analysis and cell kinetic studies were performed. Results Four low-passage novel cell lines designated RSBS-9, − 14 and − 23 from squamous cell carcinoma and RSBS-43 from adenocarcinoma of the uterine cervix were established. All were HPV16+. VNTR assay confirmed their uniqueness and derivation from respective parental tissue. CSC isolated from these cell lines showed CD133+ phenotype. In tissue samples of untreated invasive cervical cancer, CD133+ CSCs ranged from 1.3–23% of the total population which increased 2.8-fold in radiation-resistant cases. Comparison of CD133+ with CD133− bulk population cells revealed increased tumorsphere formation and upregulation of stemness and epithelial-mesenchymal transition (EMT) markers with no significant difference in cisplatin sensitivity. Conclusion Low-passage cell lines developed would serve as models for studying tumor biology. Cancer Stem Cells in cervical cancer display CD133+ phenotype and are increased in relapsed cases and hence should be targeted for achieving remission. Electronic supplementary material The online version of this article (10.1186/s12885-018-4237-5) contains supplementary material, which is available to authorized users.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::881722c58dca4a1e2f1ff97c4464c018Test
https://pubmed.ncbi.nlm.nih.gov/29609538Test

المؤلفون: Bikramjit, Das, Venkataseshan, Sundaram, William, Tarnow-Mordi, Alpana, Ghadge, Lakhbir Kaur, Dhaliwal, Praveen, Kumar

المصدر: Journal of perinatology : official journal of the California Perinatal Association. 38(5)

مصطلحات موضوعية: Male, Time Factors, Anthropometry, Placenta, Infant, Newborn, India, Infant, Gestational Age, Constriction, Umbilical Cord, Neurodevelopmental Disorders, Pregnancy, Child, Preschool, Humans, Blood Transfusion, Female, Infant, Premature

الوصف: To compare effect of placental transfusion by delayed cord clamping (DCC) or cord milking (CM) with early cord clamping (ECC) on a composite of mortality or abnormal neurological status at 40 weeks' post-menstrual age (PMA) and 24-30 months' chronological age in neonates of 30-33 weeks' gestation.Randomized, controlled trial.A composite of mortality or abnormal neurological status at 40 weeks PMA and survival free of neurodevelopmental abnormalities at 24-30 months' chronological age.A total of 461 neonates were randomized to placental transfusion (n = 233) or to ECC (n = 228). Among those assigned to placental transfusion group, 173 underwent DCC while in the remaining 60, CM was done. Incidence of mortality or abnormal neurological status at 40 weeks PMA (43 (18%) vs 35 (15%), RR (95% CI) 1.2 (0.8, 1.8), p = 0.4) and survival free of neurodevelopmental impairment at 24-30 months of chronological age (99 (47%) vs. 100 (50%); RR (95% CI): 0.9 (0.8, 1.2); P = 0.9) was similar between the study groups. The placental transfusion group showed a trend towards lower incidence of necrotizing enterocolitis.In 30-33 weeks' gestation preterm neonates, placental transfusion as compared to early cord clamping resulted in similar mortality or abnormal neurological status at 40 weeks PMA and at 24-30 months of chronological age.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=pmid________::31c314f8c8e4940cda229d06f0dc9d97Test
https://pubmed.ncbi.nlm.nih.gov/29410545Test

المؤلفون: Kanya Mukhopadhyay, Lakhbir Kaur Dhaliwal, Dhaarani Jayaraman, Anil Kumar Bhalla

المصدر: Journal of human lactation : official journal of International Lactation Consultant Association. 33(3)

مصطلحات موضوعية: Male, medicine.medical_specialty, Pediatrics, Time Factors, Birth weight, Breastfeeding, Weight Gain, law.invention, 03 medical and health sciences, 0302 clinical medicine, Randomized controlled trial, law, 030225 pediatrics, Lactation, medicine, Humans, 030212 general & internal medicine, Milk, Human, Obstetrics, business.industry, Incidence (epidemiology), Infant, Newborn, Obstetrics and Gynecology, Infant, Infant, Low Birth Weight, Kangaroo-Mother Care, Kangaroo-Mother Care Method, Low birth weight, medicine.anatomical_structure, Breast Feeding, Female, medicine.symptom, business, Breast feeding

الوصف: Background:Breastfeeding at discharge among sick low-birth-weight (LBW) infants is low despite counseling and intervention like kangaroo mother care (KMC).Research aim:The aim was to study the effects of early initiation of KMC on exclusive human milk feeding, growth, mortality, and morbidities in LBW neonates compared with late initiation of KMC during the hospital stay and postdischarge.Methods:A randomized controlled trial was conducted in level 2 and 3 areas of a tertiary care neonatal unit over 15 months. Inborn neonates weighing 1 to 1.8 kg and hemodynamically stable were randomized to receive either early KMC, initiated within the first 4 days of life, or late KMC (off respiratory support and intravenous fluids). Follow-up was until 1 month postdischarge. Outcomes were proportion of infants achieving exclusive human milk feeding and direct breastfeeding, growth, mortality and morbidities during hospital stay, and postdischarge feeding and KMC practices until 1 month.Results:The early KMC group ( n = 80) achieved significantly higher exclusive human milk feeding (86% vs. 45%, p < .001) and direct breastfeeding (49% vs. 30%, p = .021) in hospital and almost exclusive human milk feeding (73% vs. 36%, p < .001) until 1 month postdischarge than the late KMC group ( n = 80). The incidence of apnea (11.9% vs. 20%, p = .027) and recurrent apnea requiring ventilation (8.8% vs. 15%, p = .02) were significantly reduced in the early KMC group. There was no significant difference in mortality, morbidities, and growth during the hospital stay and postdischarge.Conclusion:Early KMC significantly increased exclusive human milk feeding and direct breastfeeding in LBW infants.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b6001654cc4db93a03dea7fd11c426d6Test
https://pubmed.ncbi.nlm.nih.gov/28152330Test