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1دورية أكاديمية
المؤلفون: Zsoldos, E., Filippini, N., Mahmood, A., Mackay, C.E., Singh-Manoux, A., Kivimäki, M., Jenkinson, M., Ebmeier, K.P.
مصطلحات موضوعية: Humans, Cohort Studies, Aging, Aged, 80 and over, Female, Male, Allostasis, White Matter, Gray Matter
الوصف: The allostatic load index quantifies the cumulative multisystem physiological response to chronic everyday stress, and includes cardiovascular, metabolic and inflammatory measures. Despite its central role in the stress response, research of the effect of allostatic load on the ageing brain has been limited. We investigated the relation of mid-life allostatic load index and multifactorial predictors of stroke (Framingham stroke risk) and diabetes (metabolic syndrome) with voxelwise structural grey and white matter brain integrity measures in the ageing Whitehall II cohort (N = 349, mean age = 69.6 (SD 5.2) years, N (male) = 281 (80.5%), mean follow-up before scan = 21.4 (SD 0.82) years). Higher levels of all three markers were significantly associated with lower grey matter density. Only higher Framingham stroke risk was significantly associated with lower white matter integrity (low fractional anisotropy and high mean diffusivity). Our findings provide some empirical support for the concept of allostatic load, linking the effect of everyday stress on the body with features of the ageing human brain. ; Enikő Zsoldos, Nicola Filippini, Abda Mahmood, Clare E. Mackay, Archana Singh-Manoux, Mika Kivimäki . et al.
العلاقة: Scientific Reports, 2018; 8(1):6411-6411; http://hdl.handle.net/2440/129562Test; Jenkinson, M. [0000-0001-6043-0166]
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2دورية أكاديمية
المؤلفون: Atherton, KE, Filippini, N, Zeman, AZJ, Nobre, AC, Butler, CR
المصدر: 140 ; 127
مصطلحات موضوعية: Science & Technology, Social Sciences, Life Sciences & Biomedicine, Behavioral Sciences, Neurosciences, Psychology, Experimental, Neurosciences & Neurology, Accelerated forgetting, Memory, Epilepsy, fMRI, Transient epileptic amnesia, TEMPORAL-LOBE EPILEPSY, MEMORY CONSOLIDATION, ALZHEIMERS-DISEASE, FUNCTIONAL CONNECTIVITY, PARIETAL DEACTIVATION, PATTERN SEPARATION, EPISODIC MEMORY, NEURAL ACTIVITY, HIPPOCAMPUS, IMPAIRMENT, Aged, Amnesia, Brain, Female, Humans, Learning, Male
الوصف: The accelerated forgetting of newly learned information is common amongst patients with epilepsy and, in particular, in the syndrome of transient epileptic amnesia (TEA). However, the neural mechanisms underlying accelerated forgetting are poorly understood. It has been hypothesised that interictal epileptiform activity during longer retention intervals disrupts normally established memory traces. Here, we tested a distinct hypothesis–that accelerated forgetting relates to the abnormal encoding of memories. We studied a group of 15 patients with TEA together with matched, healthy control subjects. Despite normal performance on standard anterograde memory tasks, patients showed accelerated forgetting of a word list over one week. We used a subsequent memory paradigm to compare encoding-related brain activity in patients and controls. Participants studied a series of visually presented scenes whilst undergoing functional MRI scanning. Recognition memory for these scenes was then probed outside the scanner after delays of 45 min and of 4 days. Patients showed poorer memory for the scenes compared with controls. In the patients but not the controls, subsequently forgotten stimuli were associated with reduced hippocampal activation at encoding. Furthermore, patients demonstrated reduced deactivation of posteromedial cortex regions upon viewing subsequently remembered stimuli as compared to subsequently forgotten ones. These data suggest that abnormal encoding-related activity in key memory areas of the brain contributes to accelerated forgetting in TEA. We propose that abnormally encoded memory traces may be particularly vulnerable to interference from subsequently encountered material and hence be forgotten more rapidly. Our results shed light on the mechanisms underlying memory impairment in epilepsy, and offer support to the proposal that accelerated forgetting may be a useful marker of subtle dysfunction in memory-related brain systems.
العلاقة: Cortex; http://hdl.handle.net/10044/1/91171Test
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3دورية أكاديمية
المؤلفون: Petsas N., Tomassini V., Filippini N., Sbardella E., Tona F., Piattella M. C., Pozzilli C., Wise R. G., Pantano P.
المساهمون: Petsas, N., Tomassini, V., Filippini, N., Sbardella, E., Tona, F., Piattella, M. C., Pozzilli, C., Wise, R. G., Pantano, P.
مصطلحات موضوعية: fMRI, functional connectivity, motor task, multiple sclerosi, resting state, Adult, Brain, Brain Mapping, Diffusion Tensor Imaging, Female, Gray Matter, Human, Magnetic Resonance Imaging, Male, Motor Activity, Multiple Sclerosis, Relapsing-Remitting, Neural Pathway, Regression Analysi, Rest
الوصف: Background. Resting brain activity can be modulated by motor tasks to adapt to function. In multiple sclerosis (MS) patients, altered resting-state functional connectivity (RS-FC) has been reported and associated with impaired function and disability; little is known on how RS-FC is modulated by a simple repetitive motor task. Objective. To assess changes in RS-FC in early relapsing-remitting MS (RRMS) patients associated with repetitive thumb flexions (RTFs). Methods. A total of 20 right-handed patients with early RRMS and 14 healthy controls underwent a resting functional magnetic resonance imaging (fMRI) scan, before and after 25 minutes of alternate 30-s blocks of right RTF and rest. Dual-regression analysis of resting fMRI data followed the independent component analysis. Individual spatial maps of coherence between brain areas for 2 networks of interest, sensorimotor and cerebellar, were compared at the group level and correlated with measures of both clinical impairment and brain damage. Results. Significant RTF-induced differences in RS-FC were observed between groups in the cerebellar network because of increased RS-FC in patients but not in controls. In the sensorimotor network, the RS-FC after RTF increased in both groups, with no significant between-group differences. The sensorimotor and the cerebellar RS-FC were intercorrelated only in patients and only after the RTF. The sensorimotor RS-FC increase in patients correlated with structural MRI alterations. Conclusions. Our study unmasked RS-FC changes of motor-related networks occurring after a simple repetitive motor task in early RRMS patients only. Evaluation of altered RSN dynamics might prove useful for anticipating neuroplasticity and for MRI-informed neurorehabilitation.
العلاقة: info:eu-repo/semantics/altIdentifier/pmid/25416740; info:eu-repo/semantics/altIdentifier/wos/WOS:000358313600007; volume:29; issue:6; firstpage:557; lastpage:565; numberofpages:9; journal:NEUROREHABILITATION AND NEURAL REPAIR; http://hdl.handle.net/11564/716891Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-84936946705
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المؤلفون: Suri, S, Emir, U, Stagg, C, Near, J, Mekle, R, Schubert, F, Zsoldos, E, Mahmood, A, Singh-Manoux, A, Kivimaki, M, Ebmeier, K, Mackay, C, Filippini, N
المصدر: Neuroimage
مصطلحات موضوعية: Adult, Aged, 80 and over, Male, Aging, Posterior cingulate cortex, Precuneus, Cognitive Neuroscience, Proton Magnetic Resonance Spectroscopy, Apolipoprotein E4, APOE gene, Middle Aged, Gyrus Cinguli, Article, Young Adult, Neurology, Magnetic resonance spectroscopy, Metabolites, Humans, Female, Aged
الوصف: Proton magnetic resonance spectroscopy (1H-MRS) has provided valuable information about the neurochemical profile of Alzheimer's disease (AD). However, its clinical utility has been limited in part by the lack of consistent information on how metabolite concentrations vary in the normal aging brain and in carriers of apolipoprotein E (APOE) ε4, an established risk gene for AD. We quantified metabolites within an 8 cm3 voxel within the posterior cingulate cortex (PCC)/precuneus in 30 younger (20–40 years) and 151 cognitively healthy older individuals (60–85 years). All 1H-MRS scans were performed at 3 T using the short-echo SPECIAL sequence and analyzed with LCModel. The effect of APOE was assessed in a sub-set of 130 volunteers. Older participants had significantly higher myo-inositol and creatine, and significantly lower glutathione and glutamate than younger participants. There was no significant effect of APOE or an interaction between APOE and age on the metabolite profile. Our data suggest that creatine, a commonly used reference metabolite in 1H-MRS studies, does not remain stable across adulthood within this region and therefore may not be a suitable reference in studies involving a broad age-range. Increases in creatine and myo-inositol may reflect age-related glial proliferation; decreases in glutamate and glutathione suggest a decline in synaptic and antioxidant efficiency. Our findings inform longitudinal clinical studies by characterizing age-related metabolite changes in a non-clinical sample.
وصف الملف: application/pdf
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::4a22f6002dfd59248a99180a04d3ec3bTest
http://europepmc.org/articles/PMC5440729Test -
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المؤلفون: Topiwala, A, Suri, S, Allan, C, Valkanova, V, Filippini, N, Sexton, C, Heise, V, Zsoldos, E, Mahmood, A, Singh-Manoux, A, Mackay, C, Kivimäki, M, Ebmeier, K
المصدر: PLoS ONE, Vol 14, Iss 2, p e0211273 (2019)
PLoS ONE
PLOS ONEمصطلحات موضوعية: Male, Central Nervous System, Computer and Information Sciences, Imaging Techniques, Cognitive Neuroscience, Science, Social Sciences, Neuroimaging, Pathology and Laboratory Medicine, Research and Analysis Methods, Alzheimer's Disease, Network Resilience, Nervous System, Diagnostic Radiology, Signs and Symptoms, Sociology, Diagnostic Medicine, Mental Health and Psychiatry, Medicine and Health Sciences, Humans, Cognitive Dysfunction, Social Stratification, Prospective Studies, Life Style, Aged, Cognitive Impairment, Brain Mapping, Cognitive Neurology, Radiology and Imaging, Brain, Biology and Life Sciences, Neurodegenerative Diseases, Middle Aged, Magnetic Resonance Imaging, Neurology, Cognitive Science, Medicine, Female, Dementia, Atrophy, Anatomy, Network Analysis, Research Article, Neuroscience
الوصف: Background There is significant heterogeneity in the clinical expression of structural brain abnormalities, including Alzheimer’s disease biomarkers. Some individuals preserve their memory despite the presence of risk factors or pathological brain changes, indicating resilience. We aimed to test whether resilient individuals could be distinguished from those who develop cognitive impairment, using sociodemographic variables and neuroimaging. Methods We included 550 older adults participating in the Whitehall II study with longitudinal data, cognitive test results, and multi-modal MRI. Hippocampal atrophy was defined as Scheltens Scores >0. Resilient individuals (n = 184) were defined by high cognitive performance despite hippocampal atrophy (HA). Non-resilient participants (n = 133) were defined by low cognitive performance (≥1.5 standard deviations (S.D.) below the group mean) in the presence of HA. Dynamic and static exposures were evaluated for their ability to predict later resilience status using multivariable logistic regression. In a brain-wide analysis we tested for group differences in the integrity of white matter (structural connectivity) and resting-state networks (functional connectivity). Findings Younger age (OR: 0.87, 95% CI: 0.83 to 0.92, pConclusions Resilient individuals could be distinguished from those who developed impairments on the basis of sociodemographic characteristics, brain structural and functional connectivity, but not midlife lifestyles. There was a synergistic deleterious effect of hippocampal atrophy and poor white matter integrity on cognitive performance. Exploiting and supporting neural correlates of resilience could offer a fresh approach to postpone or avoid the appearance of clinical symptoms.
وصف الملف: application/pdf
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::c77bf61ab52744939686067d42517293Test
https://doi.org/10.1371/journal.pone.0211273Test -
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المؤلفون: Akbaraly, T, Sexton, C, Zsoldos, E, Mahmood, A, Filippini, N, Kerleau, C, Michel Verdier, J, Virtanen, M, Gabelle, A, Ebmeier, K, Kivimaki, M
المساهمون: Department of Epidemiology and Public Health, Imperial College London, Mécanismes moléculaires dans les démences neurodégénératives (MMDN), Université de Montpellier (UM)-Université Montpellier 2 - Sciences et Techniques (UM2)-Institut National de la Santé et de la Recherche Médicale (INSERM)-École pratique des hautes études (EPHE), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL), Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), Department of Psychiatry, University of Oxford [Oxford], Oxford Centre for Functional Magnetic Resonance Imaging of the Brain (FMRIB), Uppsala University, Département de neurologie [Montpellier], Université Montpellier 1 (UM1)-Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier)-Hôpital Gui de Chauliac [Montpellier]-Université de Montpellier (UM), Cellules Souches, Plasticité Cellulaire, Médecine Régénératrice et Immunothérapies (IRMB), Université de Montpellier (UM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), University College of London [London] (UCL), Department of Public Health, Clinicum
المصدر: The American Journal of Medicine
The American Journal of Medicine, Elsevier [Commercial Publisher] 2018, 131 (11), pp.1372-1381.e4. ⟨10.1016/j.amjmed.2018.07.001⟩مصطلحات موضوعية: Male, HIGH-FAT DIET, Alternative Healthy Eating Index, Hippocampus, Article, Cohort Studies, Humans, Cognitive Dysfunction, Longitudinal Studies, Prospective Studies, BRAIN, Prospective study, Exercise, METAANALYSIS, ComputingMilieux_MISCELLANEOUS, Aged, Dietary indices, Nutrition and Dietetics, MORTALITY, Public Health, Global Health, Social Medicine and Epidemiology, Feeding Behavior, WHITEHALL II COHORT, Middle Aged, COGNITIVE IMPAIRMENT, DEPRESSION, Magnetic Resonance Imaging, Hippocampal volume, MEDITERRANEAN DIET, ALZHEIMERS-DISEASE, Näringslära, Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi, HEALTHY EATING INDEX, 3121 General medicine, internal medicine and other clinical medicine, Older adults, Female, Diet, Healthy, [SDV.AEN]Life Sciences [q-bio]/Food and Nutrition, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology
الوصف: BACKGROUND: Diet quality is associated with brain aging outcomes. However, few studies have explored in humans the brain structures potentially affected by long-term diet quality. We examined whether cumulative average of the Alternative Healthy Eating Index 2010 (AHEI-2010) score during adult life (an 11-year exposure period) is associated with hippocampal volume. METHODS: Analyses were based on data from 459 participants of the Whitehall II imaging sub-study (mean age [standard deviation] (SD) = 59.6 [5.3] years in 2002-2004, 19.2% women). Multimodal magnetic resonance imaging examination was performed at the end of follow-up (2015-2016). Structural images were acquired using a high-resolution 3-dimensional T1-weighted sequence and processed with Functional Magnetic Resonance Imaging of the Brain Software Library (FSL) tools. An automated model-based segmentation and registration tool was applied to extract hippocampal volumes. RESULTS: Higher AHEI-2010 cumulative average score (reflecting long-term healthy diet quality) was associated with a larger total hippocampal volume. For each 1 SD (SD = 8.7 points) increment in AHEI-2010 score, an increase of 92.5 mm(3) (standard error = 42.0 mm(3)) in total hippocampal volume was observed. This association was independent of sociodemographic factors, smoking habits, physical activity, cardiometabolic health factors, cognitive impairment, and depressive symptoms, and was more pronounced in the left hippocampus than in the right hippocampus. Of the AHEI-2010 components, no or light alcohol consumption was independently associated with larger hippocampal volume. CONCLUSIONS: Higher long-term AHEI-2010 scores were associated with larger hippocampal volume. Accounting for the importance of hippocampal structures in several neuropsychiatric diseases, our findings reaffirm the need to consider adherence to healthy dietary recommendation in multi-interventional programs to promote healthy brain aging. (C) 2018 The Authors. Published by Elsevier Inc.
وصف الملف: application/pdf
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::a71d3930e8f5b6b02606d79fc18ee846Test
http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-362397Test -
7دورية أكاديمية
المؤلفون: PETSAS, NIKOLAOS, TOMASSINI, VALENTINA, Filippini N, SBARDELLA, EMILIA, TONA, FRANCESCA, Piattella MC, POZZILLI, Carlo, Wise RG, PANTANO, Patrizia
المساهمون: Petsas, Nikolao, Tomassini, Valentina, Filippini, N, Sbardella, Emilia, Tona, Francesca, Piattella, Mc, Pozzilli, Carlo, Wise, Rg, Pantano, Patrizia
مصطلحات موضوعية: fMRI, functional connectivity, motor task, multiple sclerosi, resting state, Adult, Brain, Brain Mapping, Diffusion Tensor Imaging, Female, Gray Matter, Human, Magnetic Resonance Imaging, Male, Motor Activity, Multiple Sclerosis, Relapsing-Remitting, Neural Pathway, Regression Analysi, Rest, Rehabilitation, Neurology, Neurology (clinical)
الوصف: Resting brain activity can be modulated by motor tasks to adapt to function. In multiple sclerosis (MS) patients, altered resting-state functional connectivity (RS-FC) has been reported and associated with impaired function and disability; little is known on how RS-FC is modulated by a simple repetitive motor task. OBJECTIVE: To assess changes in RS-FC in early relapsing-remitting MS (RRMS) patients associated with repetitive thumb flexions (RTFs). METHODS: A total of 20 right-handed patients with early RRMS and 14 healthy controls underwent a resting functional magnetic resonance imaging (fMRI) scan, before and after 25 minutes of alternate 30-s blocks of right RTF and rest. Dual-regression analysis of resting fMRI data followed the independent component analysis. Individual spatial maps of coherence between brain areas for 2 networks of interest, sensorimotor and cerebellar, were compared at the group level and correlated with measures of both clinical impairment and brain damage. RESULTS: Significant RTF-induced differences in RS-FC were observed between groups in the cerebellar network because of increased RS-FC in patients but not in controls. In the sensorimotor network, the RS-FC after RTF increased in both groups, with no significant between-group differences. The sensorimotor and the cerebellar RS-FC were intercorrelated only in patients and only after the RTF. The sensorimotor RS-FC increase in patients correlated with structural MRI alterations. CONCLUSIONS: Our study unmasked RS-FC changes of motor-related networks occurring after a simple repetitive motor task in early RRMS patients only. Evaluation of altered RSN dynamics might prove useful for anticipating neuroplasticity and for MRI-informed neurorehabilitation.
العلاقة: info:eu-repo/semantics/altIdentifier/pmid/25416740; info:eu-repo/semantics/altIdentifier/wos/WOS:000358313600007; volume:29; issue:6; firstpage:---; lastpage:---; numberofpages:9; journal:NEUROREHABILITATION AND NEURAL REPAIR; http://hdl.handle.net/11573/652832Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-84936946705
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المؤلفون: AGOSTINI, ALESSANDRO, CALABRESE, CARLO, RIZZELLO, FERNANDO, GIONCHETTI, PAOLO, ERCOLANI, MAURO, CAMPIERI, MASSIMO, Benuzzi F, Filippini N, Bertani A, Scarcelli A, Farinelli V, Marchetta C, Nichelli P.
المساهمون: Agostini A, Benuzzi F, Filippini N, Bertani A, Scarcelli A, Farinelli V, Marchetta C, Calabrese C, Rizzello F, Gionchetti P, Ercolani M, Campieri M, Nichelli P
مصطلحات موضوعية: Adult, Male, brain neuroplastic changes, cingulate cortex, Crohn’s disease, frontal lobe, pain matrix, voxel-based morphometry, Brain, Magnetic Resonance Imaging, psychosomatic, BRAIN NEUROPLASTIC CHANGES, PSYCHOLOGICAL STRESS, VOXEL-BASED MORPHOMETRY, Crohn Disease, Image Interpretation, Computer-Assisted, Humans, PAIN MATRIX, Female, CROHN’S DISEASE
الوصف: Background Crohn’s disease (CD) is a chronic intestinal disorder characterized by overproduction of inflammatory cytokines and recurrent abdominal pain. Recently, brain morphological abnormalities in the pain matrix were found in patients with chronic pain disorders including irritable bowel syndrome. To investigate potential structural brain changes associated with CD, we used magnetic resonance imaging (MRI). Furthermore, we tested whether in patients gray matter (GM) volumes correlated with disease duration. Methods Eighteen CD patients in remission and 18 healthy controls underwent structural MRI. Voxel-based morphometry (VBM) is a fully automated technique allowing identification of regional differences in the amount of GM enabling an objective analysis of the whole brain between groups of subjects. VBM was used for comparisons and correlation analysis. Key Results With respect to controls, CD patients exhibited decreased GM volumes in portion of the frontal cortex and in the anterior midcingulate cortex. Disease duration was negatively correlated with GM volumes of several brain regions including neocortical and limbic areas. Conclusions & Inferences Crohn’s disease is associated with brain morphological changes in cortical and subcortical structures involved in nociception, emotional, and cognitive processes. Our findings provide new insight into the brain involvement in chronic inflammatory bowel disorders
وصف الملف: STAMPA
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::78c88e429c7b062a04418a80fd83b932Test
https://hdl.handle.net/11380/837894Test -
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المؤلفون: Griffanti, L, Jenkinson, M, Suri, S, Zsoldos, E, Mahmood, A, Filippini, N, Sexton, C, Topiwala, A, Allan, C, Kimimäki, M, Singh-Manoux, A, Ebmeier, K, Mackay, C, Zamboni, G
المصدر: Neuroimage. 170
مصطلحات موضوعية: Male, Aging, Cognitive Neuroscience, Age Factors, Leukoaraiosis, Neuroimaging, Middle Aged, Body Mass Index, Cohort Studies, Neurology, Hypertension, Humans, Cognitive Dysfunction, Female, Aged
الوصف: White matter hyperintensities (WMH) are frequently divided into periventricular (PWMH) and deep (DWMH), and the two classes have been associated with different cognitive, microstructural, and clinical correlates. However, although this distinction is widely used in visual ratings scales, how to best anatomically define the two classes is still ambiguous. In fact, the methods used to define PWMH and DWMH vary significantly between studies, making results difficult to compare. The purpose of this study was twofold: first, to compare four current criteria used to define PWMH and DWMH in a cohort of healthy older adults (mean age: 69.58 ± 5.33 years) by quantifying possible differences in terms of estimated volumes; second, to explore associations between the two WMH sub-classes with cognition, tissue microstructure and cardiovascular risk factors, analyzing the impact of different criteria on the specific associations. Our results suggest that the classification criterion used for the definition of PWMH and DWMH should not be considered a major obstacle for the comparison of different studies. We observed that higher PWMH load is associated with reduced cognitive function higher mean arterial pressure and age. Higher DWMH load is associated with higher body mass index. PWMH have lower fractional anisotropy than DWMH, which also have more heterogeneous microstructure. These findings support the hypothesis that PWMH and DWMH are different entities and that their distinction can provide useful information about healthy and pathological aging processes.
وصف الملف: application/pdf
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::284b0187239cb0ea08cf4797924231efTest
http://ora.ox.ac.uk/objects/uuidTest: -
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المؤلفون: Rosy Tambasco, Raffaele Agati, Mauro Ercolani, Nicola Filippini, Daniela Cevolani, Fernando Rizzello, Massimo Campieri, Carlo Calabrese, Alessandro Agostini, Chiara Leoni, Marco Leonardi, Paolo Gionchetti
المساهمون: Agostini A., Filippini N., Cevolani D., Agati R., Leoni C., Tambasco R., Calabrese C., Rizzello F., Gionchetti P., Ercolani M., Leonardi M., Campieri M.
المصدر: Inflammatory Bowel Diseases. 17:1769-1777
مصطلحات موضوعية: Adult, Male, Neuropsychological Tests, Emotional processing, Brain mapping, Amygdala, Thalamus, Cerebellum, Neural Pathways, Humans, Immunology and Allergy, Medicine, Colitis, EMOTIONAL PROCESSING, Brain Mapping, BRAIN FUNCTIONAL CHANGES, Blood-oxygen-level dependent, medicine.diagnostic_test, Mood Disorders, business.industry, Gastroenterology, Magnetic resonance imaging, BRAIN-GUT AXIS, medicine.disease, Magnetic Resonance Imaging, Ulcerative colitis, AMYGDALA, EMOTIONS, medicine.anatomical_structure, ULCERATIVE COLITIS, FMRI, Colitis, Ulcerative, Female, business, Functional magnetic resonance imaging, Neuroscience
الوصف: Ulcerative colitis (UC) is associated with psychological stress and poor emotional functioning. The neural emotional processing involves the complex integration of several cortical and subcortical brain structures. The amygdala plays a fundamental role in the neural processing of emotional stimuli and is a core structure of the brain-gut axis (BGA) that represents the anatomo-functional substrate for the bidirectional influences between emotions and gastrointestinal functions. The aim of this study was to investigate the brain emotional processing in UC patients compared to healthy people. METHODS: Ten UC patients in remission and 10 matched healthy controls underwent a functional magnetic resonance imaging (fMRI) scan while performing a task involving emotional visual stimuli. A set of negative, positive, and neutral pictures were used to study brain-related emotional responses. RESULTS: A significantly reduced blood oxygen level-dependent (BOLD) signal in UC patients relative to controls was found in the amygdala, thalamic regions, and cerebellar areas (P < 0.05 corrected for multiple comparisons). The group-related differences were detected in the brain activity in response to positive emotional stimuli. CONCLUSIONS: UC is associated with an emotional dysfunction characterized by decreased sensitivity to emotions with a positive content. The previous intestinal inflammatory activity in UC patients might have contributed to determine the functional changes of the amygdala that we found. On the other hand, the dysfunction of the amygdala may influence the course of the disease.
وصف الملف: STAMPA
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df93a25b60b9304fb49255133d8a8bccTest
https://doi.org/10.1002/ibd.21549Test
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