المؤلفون: Chalos, Vicky, van der Ende, Nadinda A. M., Lingsma, Hester F., Mulder, Maxim J. H. L., Venema, Esmee, Dijkland, Simone A., Berkhemer, Olvert A., Yoo, Albert J., Broderick, Joseph P., Palesch, Yuko Y., Yeatts, Sharon D., Roos, Yvo B. W. E. M., van Oostenbrugge, Robert J., van Zwam, Wim H., Majoie, Charles B. L. M., van der Lugt, Aad, Roozenbeek, Bob, Dippel, Diederik W. J., Fransen, Puck S. S., Beumer, Debbie, van den Berg, Lucie A., Schonewille, Wouter J., Vos, Jan Albert, Nederkoorn, Paul J., Wermer, Marieke J. H., van Walderveen, Marianne A. A., Staals, Julie, Hofmeijer, Jeannette, van Oostayen, Jacques A., Nijeholt, Geert J. Lycklama A., Boiten, Jelis, Brouwer, Patrick A., Emmer, Bart J., de Bruijn, Sebastiaan F., van Dijk, Lukas C., Kappelle, L. Jaap, Lo, Rob H., van Dijk, Ewoud J., de Vries, Joost, de Kort, Paul L. M., van Rooij, Willem Jan J., van den Berg, Jan S. P., van Hasselt, Boudewijn A. A. M., Aerden, Leo A. M., Dallinga, Rene J., Visser, Marieke C., Bot, Joseph C. J., Vroomen, Patrick C., Eshghi, Omid, Schreuder, Tobien H. C. M. L., Heijboer, Roel J. J., Keizer, Koos, Tielbeek, Alexander V., den Hertog, Heleen M., Gerrits, Dick G., van den Berg-Vos, Renske M., Karas, Giorgos B., Steyerberg, Ewout W., Flach, H. Zwenneke, Marquering, Henk A., Sprengers, Marieke E. S., Jenniskens, Sjoerd F. M., Beenen, Ludo F. M., van den Berg, Rene, Koudstaal, Peter J.

المساهمون: Radiology and nuclear medicine, VU University medical center, Neurology, Amsterdam Neuroscience - Neurovascular Disorders, ACS - Atherosclerosis & ischemic syndromes, Public Health, Radiology & Nuclear Medicine, Radiology and Nuclear Medicine, ANS - Neurovascular Disorders, ACS - Microcirculation, ACS - Amsterdam Cardiovascular Sciences, Graduate School, ACS - Pulmonary hypertension & thrombosis, AGEM - Digestive immunity, AGEM - Re-generation and cancer of the digestive system, ARD - Amsterdam Reproduction and Development, MUMC+: MA Neurologie (3), Klinische Neurowetenschappen, MUMC+: Hersen en Zenuw Centrum (3), RS: Carim - B05 Cerebral small vessel disease, Beeldvorming, MUMC+: DA BV Medisch Specialisten Radiologie (9), RS: Carim - B06 Imaging, MUMC+: MA AIOS Neurologie (9), MUMC+: MA Med Staf Spec Neurologie (9)

المصدر: Stroke, 51, 282-290
Stroke, 51(1), 282-290. Lippincott Williams and Wilkins
Stroke, 51(1), 282-290. Lippincott Williams & Wilkins
Stroke
Stroke; a journal of cerebral circulation, 51(1), 282-290. Lippincott Williams and Wilkins
Stroke, 51(1), 282-290. LIPPINCOTT WILLIAMS & WILKINS
Stroke, 51, 1, pp. 282-290
Stroke, 51(1), 282-290. Lippincott, Williams & Wilkins
Chalos, V, van der Ende, N A M, Lingsma, H F, Mulder, M J H L, Venema, E, Dijkland, S A, Berkhemer, O A, Yoo, A J, Broderick, J P, Palesch, Y Y, Yeatts, S D, Roos, Y B W E M, van Oostenbrugge, R J, van Zwam, W H, Majoie, C B L M, van der Lugt, A, Roozenbeek, B, Dippel, D W J, Berkhemer, O A, Fransen, P S S, Beumer, D, van den Berg, L A, Lingsma, H F, Yoo, A J, Schonewille, W J, Vos, J A, Nederkoorn, P J, Wermer, M J H, van Walderveen, M A A, Staals, J, Hofmeijer, J, van Oostayen, J A, Nijeholt, G J L A, Boiten, J, Brouwer, P A, Emmer, B J, de Bruijn, S F, van Dijk, L C, Kappelle, L J, Lo, R H, van Dijk, E J, de Vries, J, de Kort, P L M, van Rooij, W J J, van den Berg, J S P, van Hasselt, B A A M, Aerden, L A M, Dallinga, R J, Visser, M C, Bot, J C J, Vroomen, P C, Eshghi, O, Schreuder, T H C M L, Heijboer, R J J, Keizer, K, Tielbeek, A V, den Hertog, H M, Gerrits, D G, van den Berg-Vos, R M, Karas, G B, Steyerberg, E W, Flach, H Z, Marquering, H A, Sprengers, M E S, Jenniskens, S F M, Beenen, L F M, van den Berg, R & Koudstaal, P J 2020, ' National Institutes of Health Stroke Scale An Alternative Primary Outcome Measure for Trials of Acute Treatment for Ischemic Stroke ', Stroke, vol. 51, no. 1, pp. 282-290 . https://doi.org/10.1161/STROKEAHA.119.026791Test

مصطلحات موضوعية: Male, endovascular treatment, Original Contributions, 030204 cardiovascular system & hematology, law.invention, Brain Ischemia, 0302 clinical medicine, Randomized controlled trial, Modified Rankin Scale, Informed consent, law, Stroke, Netherlands, Confounding, Endovascular Procedures, informed consent, Middle Aged, Disorders of movement Donders Center for Medical Neuroscience [Radboudumc 3], stroke, 3. Good health, thrombectomy, ComputingMethodologies_DOCUMENTANDTEXTPROCESSING, outcome, Female, Cardiology and Cardiovascular Medicine, SURROGATE END-POINTS, CLINICAL-TRIALS, medicine.medical_specialty, Mechanical Thrombolysis, ENDOVASCULAR THERAPY, Clinical Sciences, 03 medical and health sciences, ALTEPLASE, Internal medicine, medicine, Humans, cardiovascular diseases, PLASMINOGEN-ACTIVATOR, Aged, Advanced and Specialized Nursing, Surrogate endpoint, business.industry, Other Research Radboud Institute for Health Sciences [Radboudumc 0], Odds ratio, medicine.disease, United States, RANDOMIZED-TRIAL, Clinical trial, SEVERITY, National Institutes of Health (U.S.), Neurology (clinical), business, 030217 neurology & neurosurgery, Follow-Up Studies, NIHSS

الوصف: Supplemental Digital Content is available in the text.
Background and Purpose— The modified Rankin Scale (mRS) at 3 months is the most commonly used primary outcome measure in stroke treatment trials, but it lacks specificity and requires long-term follow-up interviews, which consume time and resources. An alternative may be the National Institutes of Health Stroke Scale (NIHSS), early after stroke. Our aim was to evaluate whether the NIHSS assessed within 1 week after treatment could serve as a primary outcome measure for trials of acute treatment for ischemic stroke. Methods— We used data from 2 randomized controlled trials of endovascular treatment for ischemic stroke: the positive MR CLEAN (Multicenter Randomized Clinical Trial of Endovascular Treatment for Acute Ischemic Stroke in the Netherlands; N=500) and the neutral IMS (Interventional Management of Stroke) III trial (N=656). We used a causal mediation model, with linear and ordinal logistic regression adjusted for confounders, to evaluate the NIHSS 24 hours and 5 to 7 days after endovascular treatment as primary outcome measures (instead of the mRS at 3 months) in both trials. Patients who had died before the NIHSS was assessed received the maximum score of 42. NIHSS+1 was then log10-transformed. Results— In both trials, there was a significant correlation between the NIHSS at 24 hours and 5 to 7 days and the mRS. In MR CLEAN, we found a significant effect of endovascular treatment on the mRS and on the NIHSS at 24 hours and 5 to 7 days. After adjustment for NIHSS at 24 hours and 5 to 7 days, the effect of endovascular treatment on the mRS decreased from common odds ratio 1.68 (95% CI, 1.22–2.32) to respectively 1.36 (95% CI, 0.97–1.91) and 1.24 (95% CI, 0.87–1.79), indicating that treatment effect on the mRS is in large part mediated by the NIHSS. In the IMS III trial there was no treatment effect on the NIHSS at 24 hours and 5 to 7 days, corresponding with the absence of a treatment effect on the mRS. Conclusions— The NIHSS within 1 week satisfies the requirements for a surrogate end point and may be used as a primary outcome measure in trials of acute treatment for ischemic stroke, particularly in phase II(b) trials. This could reduce stroke-outcome assessment to its essentials (ie, neurological deficit), and reduce trial duration and costs. Whether and under which conditions it could be used in phase III trials requires a debate in the field with all parties. Clinical Trial Registration— URL: http://www.isrctn.comTest. Unique identifier: ISRCTN10888758; https://www.clinicaltrials.govTest. Unique identifier: NCT00359424.

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f7d5e839de565e6ffb5235e23448e4feTest
http://hdl.handle.net/2066/219673Test

المؤلفون: Santos, Emilie M. M., Yoo, Albert J., Beenen, Ludo F., Berkhemer, Olvert A., den Blanken, Mark D., Wismans, Carrie, Niessen, Wiro J., Majoie, Charles B., Marquering, Henk A., Fransen, Puck S. S., Beumer, Debbie, van den Berg, Lucie A., Lingsma, Hester F., Schonewille, Wouter J., Vos, Jan Albert, Nederkoorn, Paul J., Wermer, Marieke J. H., van Walderveen, Marianne A. A., Staals, Julie, Hofmeijer, Jeannette, van Oostayen, Jacques A., Lycklama à Nijeholt, Geert J., Boiten, Jelis, Brouwer, Patrick A., Emmer, Bart J., de Bruijn, Sebastiaan F., van Dijk, Lukas C., Kappelle, L. Jaap, Lo, Rob H., van Dijk, Ewoud J., de Vries, Joost, de Kort, Paul L. M., van den Berg, Jan S. P., A A M van Hasselt, Boudewijn, Aerden, Leo A. M., Dallinga, René J., Visser, Marieke C., Bot, Joseph C. J., Vroomen, Patrick C., Eshghi, Omid, Schreuder, Tobien H. C. M. L., Heijboer, Roel J. J., Keizer, Koos, Tielbeek, Alexander V., Hertog, Heleen M. Den, Gerrits, Dick G., van den Berg-Vos, Renske M., Sprengers, Marieke E. S., van den Berg, René, Roos, Yvo B. W. E. M.

المساهمون: Beeldvorming, MUMC+: DA BV Medisch Specialisten Radiologie (9), RS: CARIM - R3.11 - Imaging, MUMC+: MA Neurologie (3), Klinische Neurowetenschappen, RS: CARIM - R3.03 - Cerebral small vessel disease, Other departments, ANS - Neurovascular Disorders, Graduate School, Radiology and Nuclear Medicine, Other Research, ACS - Amsterdam Cardiovascular Sciences, Biomedical Engineering and Physics, Neurology, Radiology & Nuclear Medicine

المصدر: Neuroradiology, 58(2), 133-139. Springer, Cham
Neuroradiology, 58, 2, pp. 133-9
Neuroradiology
Neuroradiology, 58(2), 133-139. Springer Verlag
Neuroradiology, 58(2), 133-139. Springer-Verlag
Neuroradiology, 58, 133-9

مصطلحات موضوعية: Male, Observer (quantum physics), Computed Tomography Angiography, Intraclass correlation, Clinical Neurology, Sensitivity and Specificity, 030218 nuclear medicine & medical imaging, X-ray, 03 medical and health sciences, Brain ischemia, Absorptiometry, Photon, 0302 clinical medicine, Thromboembolism, Observer agreements, medicine, Humans, Radiology, Nuclear Medicine and imaging, In patient, cardiovascular diseases, Thrombus, Acute ischemic stroke, Computed tomography, Diagnostic Neuroradiology, Aged, Netherlands, Neuroradiology, Observer Variation, Measurement method, business.industry, Reproducibility of Results, Thrombosis, Disorders of movement Donders Center for Medical Neuroscience [Radboudumc 3], medicine.disease, Cerebral Angiography, Radiographic Image Enhancement, Stroke, Radiology Nuclear Medicine and imaging, Interobserver Variation, Acute Disease, Radiographic Image Interpretation, Computer-Assisted, Female, Neurology (clinical), Intracranial Thrombosis, Cardiology and Cardiovascular Medicine, business, Nuclear medicine, Algorithms, 030217 neurology & neurosurgery

الوصف: Introduction Thrombus density may be a predictor for acute ischemic stroke treatment success. However, only limited data on observer variability for thrombus density measurements exist. This study assesses the variability and bias of four common thrombus density measurement methods by expert and non-expert observers. Methods For 132 consecutive patients with acute ischemic stroke, three experts and two trained observers determined thrombus density by placing three standardized regions of interest (ROIs) in the thrombus and corresponding contralateral arterial segment. Subsequently, absolute and relative thrombus densities were determined using either one or three ROIs. Intraclass correlation coefficient (ICC) was determined, and Bland–Altman analysis was performed to evaluate interobserver and intermethod agreement. Accuracy of the trained observer was evaluated with a reference expert observer using the same statistical analysis. Results The highest interobserver agreement was obtained for absolute thrombus measurements using three ROIs (ICCs ranging from 0.54 to 0.91). In general, interobserver agreement was lower for relative measurements, and for using one instead of three ROIs. Interobserver agreement of trained non-experts and experts was similar. Accuracy of the trained observer measurements was comparable to the expert interobserver agreement and was better for absolute measurements and with three ROIs. The agreement between the one ROI and three ROI methods was good. Conclusion Absolute thrombus density measurement has superior interobserver agreement compared to relative density measurement. Interobserver variation is smaller when multiple ROIs are used. Trained non-expert observers can accurately and reproducibly assess absolute thrombus densities using three ROIs. Electronic supplementary material The online version of this article (doi:10.1007/s00234-015-1607-4) contains supplementary material, which is available to authorized users.

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الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::155812c33ccf89424bee62a0a3f97a23Test
https://cris.maastrichtuniversity.nl/en/publications/e123bebd-53d3-452d-b514-f34959454c36Test

المؤلفون: Santos, Emilie M. M., Niessen, Wiro J., Yoo, Albert J., Berkhemer, Olvert A., Beenen, Ludo F., Majoie, Charles B., Marquering, Henk A., Fransen, Puck S. S., Beumer, Debbie, van den Berg, Lucie A., Lingsma, Hester F., Schonewille, Wouter J., Vos, Jan Albert, Nederkoorn, Paul J., Wermer, Marieke J. H., van Walderveen, Marianne A. A., Staals, Julie, Hofmeijer, Jeannette, van Oostayen, Jacques A., Lycklama à Nijeholt, Geert J., Boiten, Jelis, Brouwer, Patrick A., Emmer, Bart J., de Bruijn, Sebastiaan F., van Dijk, Lukas C., Kappelle, L. Jaap, Lo, Rob H., van Dijk, Ewoud J., de Vries, Joost, de Kort, Paul L. M., van den Berg, Jan S. P., van Hasselt, Boudewijn A. A. M., Aerden, Leo A. M., Dallinga, René J., Visser, Marieke C., Bot, Joseph C. J., Vroomen, Patrick C., Eshghi, Omid, Schreuder, Tobien H. C. M. L., Heijboer, Roel J. J., Keizer, Koos, Tielbeek, Alexander V., den Hertog, Heleen M., Gerrits, Dick G., van den Berg-Vos, Renske M., Karas, Giorgos B., Steyerberg, Ewout W., Sprengers, Marieke E. S., van den Berg, René, Roos, Yvo B. W. E. M.

المساهمون: Other departments, Radiology and Nuclear Medicine, ACS - Amsterdam Cardiovascular Sciences, ANS - Neurovascular Disorders, Graduate School, Other Research, Biomedical Engineering and Physics, Neurology, Public and occupational health, EMGO - Quality of care, Radiology and nuclear medicine, Amsterdam Neuroscience - Neurovascular Disorders, Medical Informatics, Radiology & Nuclear Medicine, MUMC+: MA Neurologie (3), Klinische Neurowetenschappen, RS: CARIM - R3.03 - Cerebral small vessel disease, Beeldvorming, MUMC+: DA BV Medisch Specialisten Radiologie (9), RS: CARIM - R3.11 - Imaging

المصدر: PLoS ONE, 11(1). Public Library of Science
PLoS ONE, 11(1):e0145641. Public Library of Science
PLoS One, 11
MR CLEAN Investigators 2016, ' Automated entire thrombus density measurements for robust and comprehensive thrombus characterization in patients with acute ischemic stroke ', PLoS ONE, vol. 11, no. 1, e0145641 . https://doi.org/10.1371/journal.pone.0145641Test
PLoS ONE, Vol 11, Iss 1, p e0145641 (2016)
PLoS ONE
PLoS One (print), 11(1). Public Library of Science
PLOS ONE, 11(1):e0145641. Public Library of Science
PLoS One, 11, 1
PLoS ONE, 11(1):e0145641. PUBLIC LIBRARY SCIENCE

مصطلحات موضوعية: Male, medicine.medical_specialty, lcsh:Medicine, Research Support, 030218 nuclear medicine & medical imaging, 03 medical and health sciences, Absorptiometry, Photon, 0302 clinical medicine, Interquartile range, Linear regression, medicine, Journal Article, Humans, cardiovascular diseases, Thrombus, Absorptiometry, lcsh:Science, Non-U.S. Gov't, Stroke, Acute ischemic stroke, Tomography, Aged, Multidisciplinary, business.industry, Research Support, Non-U.S. Gov't, lcsh:R, Thrombosis, Cerebral Arteries, Middle Aged, Disorders of movement Donders Center for Medical Neuroscience [Radboudumc 3], medicine.disease, Photon, Internal, X-Ray Computed, Kurtosis, cardiovascular system, lcsh:Q, Female, Radiology, Carotid Artery, Tomography, X-Ray Computed, business, Carotid Artery, Internal, 030217 neurology & neurosurgery, Research Article, circulatory and respiratory physiology

الوصف: Contains fulltext : 168317.PDF (Publisher’s version ) (Open Access) BACKGROUND AND PURPOSE: In acute ischemic stroke (AIS) management, CT-based thrombus density has been associated with treatment success. However, currently used thrombus measurements are prone to inter-observer variability and oversimplify the heterogeneous thrombus composition. Our aim was first to introduce an automated method to assess the entire thrombus density and then to compare the measured entire thrombus density with respect to current standard manual measurements. MATERIALS AND METHOD: In 135 AIS patients, the density distribution of the entire thrombus was determined. Density distributions were described using medians, interquartile ranges (IQR), kurtosis, and skewedness. Differences between the median of entire thrombus measurements and commonly applied manual measurements using 3 regions of interest were determined using linear regression. RESULTS: Density distributions varied considerably with medians ranging from 20.0 to 62.8 HU and IQRs ranging from 9.3 to 55.8 HU. The average median of the thrombus density distributions (43.5 +/- 10.2 HU) was lower than the manual assessment (49.6 +/- 8.0 HU) (p

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be38c21d9bdcbd8fd9a5611a27d3ea93Test
https://pure.amc.nl/en/publications/automated-entire-thrombus-density-measurements-for-robust-and-comprehensive-thrombus-characterization-in-patients-with-acute-ischemic-strokeTest(8a0b0565-4d91-455c-ad19-7a27d7182982).html

المؤلفون: Kimberly, W. Taylor, Dutra, Bruna Garbugio, Boers, Anna M. M., Alves, Heitor C. B. R., Berkhemer, Olvert A., van den Berg, Lucie, Sheth, Kevin N., Roos, Yvo B. W. E. M., van der Lugt, Aad, Beenen, Ludo F. M., Dippel, Diederik W. J., van Zwam, Wim H., van Oostenbrugge, Robert J., Lingsma, Hester F., Marquering, Henk, Majoie, Charles B. L. M., Koudstaal, Peter J., van den Berg, Lucie A., Nederkoorn, Paul J., Beumer, Debbie, Staals, Julie, Boiten, Jelis, Wermer, Marieke J. H., Kappelle, L. Jaap, van Dijk, Ewoud J., Schonewille, Wouter J., Hofmeijer, Jeannette, van Oostayen, Jacques A., Vroomen, Patrick C., de Kort, Paul L. M., Keizer, Koos, de Bruijn, Sebastiaan F., van den Berg, J. S. Peter, Schreuder, Tobien H. C. M. L., Aerden, Leo A. M., Flach, H. Zwenneke, Visser, Marieke C., den Hertog, Heleen M., Brouwer, Patrick A., Emmer, Bart J., Sprengers, Marieke E. S., van den Berg, René, Nijeholt, Geert J. Lycklamaà, van Walderveen, Marianne A. A., Lo, Rob H., de Vries, Joost, Vos, Jan Albert, Eshghi, Omid, Tielbeek, Alexander V., van Dijk, Lukas C., van Hasselt, Boudewijn A. A. M., Heijboer, Roel J. J., Dallinga, René J., Bot, Joseph C. J., Gerrits, Dick G., Fransen, Puck S. S., Marquering, Henk A., Steyerberg, Ewout W., Yoo, Albert J., Jenniskens, Sjoerd F. M., van den Berg-Vos, Renske M., Karas, Giorgos B., Brown, Martin M., Liebig, Thomas, Stijnen, Theo, Andersson, Tommy, Mattle, Heinrich, Wahlgren, Nils, van der Heijden, Esther, Ghannouti, Naziha, Fleitour, Nadine, Hooijenga, Imke, Puppels, Corina, Pellikaan, Wilma, Geerling, Annet, Lindl-Velema, Annemieke, van Vemde, Gina, Klinieken, Isala, de Ridder, Ans, Greebe, Paut, de Bont-Stikkelbroeck, José, de Meris, Joke, Janssen, Kirsten, Struijk, Willy, Licher, Silvan, Boodt, Nikki, Ros, Adriaan, Venema, Esmee, Slokkers, Ilse, Ganpat, Raymie-Jayce, Mulder, Maxim, Saiedie, Nawid, Heshmatollah, Alis, Schipperen, Stefanie, Vinken, Stefan, van Boxtel, Tiemen, Koets, Jeroen

المساهمون: Neurology, Radiology & Nuclear Medicine, Public Health, Radiology and nuclear medicine, VU University medical center, Amsterdam Neuroscience - Neurovascular Disorders, Beeldvorming, RS: CARIM - R3.03 - Cerebral small vessel disease, RS: CARIM - R3.11 - Imaging, MUMC+: DA BV Medisch Specialisten Radiologie (9), RS: MHeNs - R1 - Cognitive Neuropsychiatry and Clinical Neuroscience, Klinische Neurowetenschappen, MUMC+: MA Neurologie (3), Radiology and Nuclear Medicine, ACS - Amsterdam Cardiovascular Sciences, ANS - Neurovascular Disorders, Graduate School, Other Research, ARD - Amsterdam Reproduction and Development, AGEM - Amsterdam Gastroenterology Endocrinology Metabolism, ACS - Microcirculation, ACS - Atherosclerosis & ischemic syndromes, ACS - Pulmonary hypertension & thrombosis

المصدر: JAMA Neurology, 75(4), 453-461. American Medical Association
JAMA Neurology, 75(4), 453. American Medical Association
Kimberly, W T, Dutra, B G, Boers, A M M, Alves, H C B R, Berkhemer, O A, van den Berg, L, Sheth, K N, Roos, Y B W E M, van der Lugt, A, Beenen, L F M, Dippel, D W J, van Zwam, W H, van Oostenbrugge, R J, Lingsma, H F, Marquering, H, Majoie, C B L M, Koudstaal, P J, van den Berg, L A, Nederkoorn, P J, Beumer, D, Staals, J, Boiten, J, Wermer, M J H, Kappelle, L J, van Dijk, E J, Schonewille, W J, Hofmeijer, J, van Oostayen, J A, Vroomen, P C, de Kort, P L M, Keizer, K, de Bruijn, S F, van den Berg, J S P, Schreuder, T H C M L, Aerden, L A M, Flach, H Z, Visser, M C, den Hertog, H M, Brouwer, P A, Emmer, B J, Sprengers, M E S, van den Berg, R, Nijeholt, G J L, van Walderveen, M A A, Lo, R H, de Vries, J, Vos, J A, Eshghi, O, Tielbeek, A V, van Dijk, L C, van Hasselt, B A A M, Heijboer, R J J, Dallinga, R J, Bot, J C J, Gerrits, D G, Fransen, P S S, Marquering, H A, Steyerberg, E W, Yoo, A J, Jenniskens, S F M, van den Berg-Vos, R M, Karas, G B, Brown, M M, Liebig, T, Stijnen, T, Andersson, T, Mattle, H, Wahlgren, N, van der Heijden, E, Ghannouti, N, Fleitour, N, Hooijenga, I, Puppels, C, Pellikaan, W, Geerling, A, Lindl-Velema, A, van Vemde, G, Klinieken, I, de Ridder, A, Greebe, P, de Bont-Stikkelbroeck, J, de Meris, J, Janssen, K, Struijk, W, Licher, S, Boodt, N, Ros, A, Venema, E, Slokkers, I, Ganpat, R-J, Mulder, M, Saiedie, N, Heshmatollah, A, Schipperen, S, Vinken, S, van Boxtel, T & Koets, J 2018, ' Association of reperfusion with brain edema in patients with acute ischemic stroke: A secondary analysis of the MR CLEAN Trial ', JAMA Neurology, vol. 75, no. 4, pp. 453-461 . https://doi.org/10.1001/jamaneurol.2017.5162Test

مصطلحات موضوعية: Male, medicine.medical_specialty, medicine.medical_treatment, Infarction, Brain Edema, ANGIOGRAPHY, THERAPY, Cerebral edema, Brain Ischemia, 03 medical and health sciences, 0302 clinical medicine, Midline shift, Modified Rankin Scale, Internal medicine, Outcome Assessment, Health Care, medicine, INJURY, Journal Article, Humans, 030212 general & internal medicine, cardiovascular diseases, PREDICTORS, Stroke, Aged, Netherlands, Retrospective Studies, Original Investigation, THROMBOLYSIS, business.industry, Cerebral infarction, Endovascular Procedures, Odds ratio, Thrombolysis, Middle Aged, medicine.disease, MIDDLE-CEREBRAL-ARTERY, DIFFUSION, THRESHOLDS, Treatment Outcome, TISSUE, Reperfusion, Cardiology, Female, Neurology (clinical), business, INFARCTION, 030217 neurology & neurosurgery

الوصف: Importance: It is uncertain whether therapeutic reperfusion with endovascular treatment yields more or less brain edema. Objective: To elucidate the association between reperfusion and brain edema. The secondary objectives were to evaluate whether brain edema could partially be responsible for worse outcomes in patients with later reperfusion or lower Alberta Stroke Program Early Computed Tomography Score. Design, Setting, and Participants: This was a post hoc analysis of the Multicenter Randomized Clinical Trial of Endovascular Treatment for Acute Ischemic Stroke in the Netherlands (MR CLEAN), which was a prospective, randomized, multicenter clinical trial of endovascular treatment compared with conventional care of patients with acute anterior circulation ischemic stroke. Of 502 patients enrolled from December 2010 to June 2014, 2 patients declined to participate. Additionally, exclusion criteria were absence of follow-up imaging or presence of parenchymal hematoma, resulting in 462 patients included in this study. Brain edema was assessed retrospectively, from December 10, 2016, to July 24, 2017, by measuring midline shift (MLS) in all available follow-up scans. Observers were blinded to clinical data. Main Outcomes and Measures: Midline shift was assessed as present or absent and as a continuous variable. Reperfusion status was assessed by the modified thrombolysis in cerebral infarction score in the endovascular treatment arm. The modified arterial occlusive lesion score was used to evaluate the recanalization status in both arms. The modified Rankin scale score at 90 days was used for functional outcome. Results: Of 462 patients, the mean (SD) age was 65 (11) years, and 41.8% (n = 193) were women. Successful reperfusion and recanalization were associated with a reduced likelihood of having MLS (adjusted common odds ratio, 0.25; 95% CI, 0.12-0.53; P

وصف الملف: image/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c0ee93941dd2c5b972bd0578fb231355Test
https://hdl.handle.net/1874/377272Test