Castleman disease-associated diffuse parenchymal lung disease
| العنوان: | Castleman disease-associated diffuse parenchymal lung disease |
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| المؤلفون: | Huang, Hui, Feng, Ruie, Li, Jian, Song, Xinyu, Li, Shan, Xu, Kai, Cao, Jian, Zhang, Lu, Bi, Yalan, Xu, Zuojun |
| المصدر: | Medicine |
| بيانات النشر: | Wolters Kluwer Health, 2017. |
| سنة النشر: | 2017 |
| مصطلحات موضوعية: | Adult, Image-Guided Biopsy, Male, China, Castleman disease, Thoracic Surgery, Video-Assisted, Age Factors, Observational Study, Lymphadenopathy, Middle Aged, lung, Sex Factors, Drug Therapy, Prevalence, Humans, Female, Symptom Assessment, Lung Diseases, Interstitial, Tomography, X-Ray Computed, diffuse parenchymal lung disease, Research Article, Retrospective Studies |
| الوصف: | Intrathoracic involvement is common in Castleman disease (CD), but CD-associated diffuse parenchymal lung disease (DPLD) is rare and not well-reported. We conducted a retrospective analysis of 262 CD patients with a definite pathological diagnosis who were hospitalized between 1999 and 2015. Twenty-two CD patients had DPLD based on chest computed tomography (CT) scans. Among them, 9 were male and 13 were female, with a mean age of 45.3 years. Coughing (72.7%), fever (68.2%), and dyspnea (59.1%) were the common clinical manifestations. In high-resolution CT, obvious lymphadenopathy (81.8%) was the most frequent, followed by multiple nodules of different sizes (72.7%), cysts (59.1%), and patches of ground-glass opacity (54.5%). Six patients had lymphocytic interstitial pneumonia (LIP)-like CT images. Superficial lymph node biopsies (63.6%), video-assisted thoracic surgery lung biopsies (27.3%), CT-guided percutaneous lung biopsies (9.1%), and endoscopic lymph node biopsies (9.1%) were performed to make final diagnoses. The hyaline vascular variant (27.3%), the plasma cell variant (63.6%), and the mixed variant (9.1%) were the pathological subtypes. All but 2 were prescribed chemotherapy, and none was administered anti-interleukin-6 therapy. Among them, 14 patients improved, 3 died, 2 were stable, 2 were refractory, and 1 was lost to follow-up. Chinese CD-associated DPLD might be more prevalent in middle-aged female patients, with most cases being the plasma cell variant. Although a LIP-like pattern was reported, only one-quarter of the patients showed LIP-like CT images. Multiple nodules (especially solid nodules), cysts, and patchy areas were the common pulmonary radiological findings. More than half of the patients improved after chemotherapy. A well-designed prospective study should be performed to confirm these results. |
| اللغة: | English |
| تدمد: | 1536-5964 0025-7974 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=pmid________::c52a3b58e43049f07ee014c6bbe44441Test http://europepmc.org/articles/PMC5626314Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.pmid..........c52a3b58e43049f07ee014c6bbe44441 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15365964 00257974 |
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