دورية أكاديمية
Beyond the Scavenging of Reactive Oxygen Species (ROS): Direct Effect of Cerium Oxide Nanoparticles in Reducing Fatty Acids Content in an In Vitro Model of Hepatocellular Steatosis
| العنوان: | Beyond the Scavenging of Reactive Oxygen Species (ROS): Direct Effect of Cerium Oxide Nanoparticles in Reducing Fatty Acids Content in an In Vitro Model of Hepatocellular Steatosis |
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| المؤلفون: | Parra Robert, Marina, Casals, Eudald, Massana, Núria, Zeng, Muling, Perramón, Meritxell, Fernández Varo, Guillermo, Morales Ruiz, Manuel, Puntes, Víctor, Jiménez Povedano, Wladimiro, Casals Mercadal, Gregori |
| المصدر: | Articles publicats en revistes (Biomedicina) |
| بيانات النشر: | MDPI |
| سنة النشر: | 2019 |
| المجموعة: | Dipòsit Digital de la Universitat de Barcelona |
| مصطلحات موضوعية: | Malalties del fetge, Àcids grassos, Estrès oxidatiu, Liver diseases, Fatty acids, Oxidative stress |
| الوصف: | Nonalcoholic fatty liver disease (NAFLD) is characterized by hepatic accumulation of lipids. Antisteatotic effects of cerium oxide nanoparticles (CeO2NPs) have recently been shown in animal models of liver disease. However, it is unclear whether the activity of CeO2NPs is related solely to the decrease in oxidative stress or, in addition, they directly decrease liver fatty acid accumulation. To address this question, in this work, we used an in vitro model of hepatocellular steatosis, exposing HepG2 cells to oleic and palmitic acid. Cell uptake of CeO2NPs and their effect on oxidative stress and viability of hepatic cells cultured with H2O2 were also evaluated. Results show that CeO2NPs were uptaken by HepG2 cells and reduced oxidative stress and improved cell viability. Treatment with oleic and palmitic acid increased lipogenesis and the content of different fatty acids. CeO2NPs reduced palmitic and stearic acid and most fatty acids consisting of more than 18 carbon atoms. These effects were associated with significant changes in elongase and desaturase activity. In conclusion, CeO2NPs directly protected HepG2 cells from cell injury in oxidative stress conditions and reduced fatty acid content in steatotic conditions by inducing specific changes in fatty acid metabolism, thus showing potential in the treatment of NAFLD. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | 16 p.; application/pdf |
| اللغة: | English |
| تدمد: | 2218-273X |
| العلاقة: | Reproducció del document publicat a: https://doi.org/10.3390/biom9090425Test; Biomolecules, 2019, vol. 9, num. 9, p. 425; https://doi.org/10.3390/biom9090425Test; http://hdl.handle.net/2445/176067Test; 693876 |
| الإتاحة: | https://doi.org/10.3390/biom9090425Test http://hdl.handle.net/2445/176067Test |
| حقوق: | cc-by (c) Parra Robert, Marina et al., 2019 ; http://creativecommons.org/licenses/by/3.0/esTest ; info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.A126652E |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 2218273X |
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