دورية أكاديمية
Tissue-specific roles of peroxisomes revealed by expression meta-analysis
| العنوان: | Tissue-specific roles of peroxisomes revealed by expression meta-analysis |
|---|---|
| المؤلفون: | Plessner, Matthias, Thiele, Leonie, Hofhuis, Julia, Thoms, Sven |
| بيانات النشر: | Biomed Central |
| سنة النشر: | 2024 |
| المجموعة: | PUB - Publications at Bielefeld University |
| مصطلحات موضوعية: | Peroxisome, Heart, Peroxisome biogenesis, Ether lipids, Plasmalogens, Alpha-oxidation, Metabolism, Lipids, Fatty acids, ddc:610 |
| الوصف: | Plessner M, Thiele L, Hofhuis J, Thoms S. Tissue-specific roles of peroxisomes revealed by expression meta-analysis. Biology direct . 2024;19(1): 14. ; Peroxisomes are primarily studied in the brain, kidney, and liver due to the conspicuous tissue-specific pathology of peroxisomal biogenesis disorders. In contrast, little is known about the role of peroxisomes in other tissues such as the heart. In this meta-analysis, we explore mitochondrial and peroxisomal gene expression on RNA and protein levels in the brain, heart, kidney, and liver, focusing on lipid metabolism. Further, we evaluate a potential developmental and heart region-dependent specificity of our gene set. We find marginal expression of the enzymes for peroxisomal fatty acid oxidation in cardiac tissue in comparison to the liver or cardiac mitochondrial beta-oxidation. However, the expression of peroxisome biogenesis proteins in the heart is similar to other tissues despite low levels of peroxisomal fatty acid oxidation. Strikingly, peroxisomal targeting signal type 2-containing factors and plasmalogen biosynthesis appear to play a fundamental role in explaining the essential protective and supporting functions of cardiac peroxisomes. © 2024. The Author(s). |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | info:eu-repo/semantics/altIdentifier/issn/1745-6150; info:eu-repo/semantics/altIdentifier/wos/001163634800001; info:eu-repo/semantics/altIdentifier/pmid/38365851; https://nbn-resolving.org/urn:nbn:de:0070-pub-29873656Test; https://pub.uni-bielefeld.de/record/2987365Test; https://pub.uni-bielefeld.de/download/2987365/2990584Test |
| الإتاحة: | https://doi.org/10.1186/s13062-024-00458-1Test https://nbn-resolving.org/urn:nbn:de:0070-pub-29873656Test https://pub.uni-bielefeld.de/record/2987365Test https://pub.uni-bielefeld.de/download/2987365/2990584Test |
| حقوق: | https://creativecommons.org/licenses/by/4.0Test/ ; info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.C993E6F6 |
| قاعدة البيانات: | BASE |
| الوصف غير متاح. |