المؤلفون: Kang Li, Haixiang Sun, Jingzi Zhang, Yue Hua, Hai-Quan Wang, Qiang Wang, Min-Sheng Zhu, Yong-Juan Sang, Xin-Ying Wang, Chao-Jun Li, Feng Zheng, Yue Zhao

المصدر: Journal of Molecular Cell Biology

مصطلحات موضوعية: RHOA, Geranylgeranyl pyrophosphate, Organogenesis, Farnesyl pyrophosphate, Bioinformatics, AcademicSubjects/SCI01180, Uterine contraction, chemistry.chemical_compound, Mice, Uterine Contraction, Ovarian Follicle, Pregnancy, reproductive and urinary physiology, Mice, Knockout, rho-Associated Kinases, biology, General Medicine, Articles, Phenotype, Female, GGPS1, medicine.symptom, Protein Binding, Signal Transduction, Statin, medicine.drug_class, Prenylation, Multienzyme Complexes, Genetics, medicine, Animals, Farnesyltranstransferase, Genetic Predisposition to Disease, Molecular Biology, Genetic Association Studies, Granulosa Cells, business.industry, Uterus, dystocia, statin, protein prenylation, RhoA, Cell Biology, Disease Models, Animal, chemistry, Infertility, biology.protein, Protein prenylation, business, rhoA GTP-Binding Protein, Biomarkers

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9712ac01bacc39dc4a04c1eb045eda3fTest
http://europepmc.org/articles/PMC8104943Test

المؤلفون: Shan Guan, Na Xu, Chao-Jun Li, Tongyu Zhang, Danyang Chong, Yue Zhao, Zhong Chen

المصدر: Journal of genetics and genomics = Yi chuan xue bao. 48(4)

مصطلحات موضوعية: RHOA, Geranylgeranyl pyrophosphate, Protein Prenylation, Embryonic Development, Apoptosis, Biology, 03 medical and health sciences, chemistry.chemical_compound, Mice, 0302 clinical medicine, Vasculogenesis, Geranylgeraniol, Polyisoprenyl Phosphates, Multienzyme Complexes, Pregnancy, Genetics, Morphogenesis, Animals, Farnesyltranstransferase, Molecular Biology, 030304 developmental biology, Cell Proliferation, 0303 health sciences, Cell growth, Endothelial Cells, Cell Differentiation, YAP-Signaling Proteins, Embryo, Mammalian, Embryonic stem cell, Cell biology, Endothelial stem cell, chemistry, biology.protein, Female, Mevalonate pathway, rhoA GTP-Binding Protein, 030217 neurology & neurosurgery

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::398b028852f54f055e3c4b8b4efc1e36Test
https://pubmed.ncbi.nlm.nih.gov/34049800Test

المؤلفون: Sandra Whalen, Juliette Dupont, Sandrine Vuillaumier-Barrot, Chloe Hanna, Gorjana Robevska, Phillipa J. Lamont, Lurdes Sampaio, John Christodoulou, Rocio Rius, Elena J. Tucker, André Travessa, Jocelyn van den Bergen, Andrew H. Sinclair, Arnaud Isapof, Katrina M. Bell, Andrea Simpson, Jérôme Dulon, Sylvie Jaillard, Tanya Stojkovic, Susana Quijano-Roy, David R. Thorburn, Katie L. Ayers, Philippe Touraine

المساهمون: Murdoch Children's Research Institute (MCRI), University of Melbourne, CHU Pontchaillou [Rennes], Institut de recherche en santé, environnement et travail (Irset), Université d'Angers (UA)-Université de Rennes (UR)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), Sorbonne Université (SU), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), AP-HP - Hôpital Bichat - Claude Bernard [Paris], Filière Neuromusculaire (FILNEMUS), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ), National Health and Medical Research Council (NHMRC)National Health and Medical Research Council of Australia [1113531], NHMRCNational Health and Medical Research Council of Australia [1074258, 1054432, 1062854, 1155244], CONACYTConsejo Nacional de Ciencia y Tecnologia (CONACyT), Victorian Government's Operational Infrastructure Support Program, Université d'Angers (UA)-Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique )

المصدر: Human Genetics
Human Genetics, 2020, 139 (10), pp.1325-1343. ⟨10.1007/s00439-020-02176-w⟩
Human Genetics, Springer Verlag, 2020, 139 (10), pp.1325-1343. ⟨10.1007/s00439-020-02176-w⟩

مصطلحات موضوعية: Adult, Male, Candidate gene, Adolescent, Mitochondrial translation, Hearing Loss, Sensorineural, [SDV]Life Sciences [q-bio], Gene Expression, Biology, DNA, Mitochondrial, Amino Acyl-tRNA Synthetases, Mitochondrial Proteins, 03 medical and health sciences, Peroxisomal disorder, Genetics, medicine, Peroxisomes, Farnesyltranstransferase, Humans, Genetic Predisposition to Disease, Child, Genetics (clinical), 030304 developmental biology, 0303 health sciences, Base Sequence, 030305 genetics & heredity, Ovary, High-Throughput Nucleotide Sequencing, Geranyltranstransferase, Endopeptidase Clp, TFAM, medicine.disease, Dimethylallyltranstransferase, Human genetics, Premature ovarian failure, Gonadal Dysgenesis, 46,XX, Pedigree, DNA-Binding Proteins, Protein prenylation, ATPases Associated with Diverse Cellular Activities, Female, PEX6, Transcription Factors

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c24b1eaa8ecc2ffcfe237546d81b48c2Test
https://univ-rennes.hal.science/hal-02796991Test

المؤلفون: Shao H. Yang, Douglas A. Andres, Yibin Wang, Stephen G. Young, Loren G. Fong, H. Peter Spielmann, Shuxun Ren, Sandy Y. Chang

المصدر: Human Molecular Genetics. 20:436-444

مصطلحات موضوعية: Male, congenital, hereditary, and neonatal diseases and abnormalities, Protein Prenylation, Biology, Mice, Progeria, Prenylation, Gene knockin, Genetics, medicine, Animals, Farnesyltranstransferase, Gene Knock-In Techniques, Enzyme Inhibitors, Protein Precursors, Allele, Nuclear protein, Molecular Biology, Genetics (clinical), integumentary system, Farnesyltransferase inhibitor, Imidazoles, Nuclear Proteins, Articles, General Medicine, Lamin Type A, Progerin, medicine.disease, Molecular biology, Phenotype, Amino Acid Substitution, Mutation, Cancer research, Protein prenylation, Female

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::884fedf31d7f8a145a658c5b17c90dc4Test
https://doi.org/10.1093/hmg/ddq490Test

المؤلفون: Shaowu Cheng, Ling Li, David A. Hottman, Martin O. Bergo, Li-Lian Yuan, Dongfeng Cao

المصدر: Journal of Biological Chemistry. 288:35952-35960

مصطلحات موضوعية: Farnesyltransferase, Mice, Transgenic, Neuropathology, Biochemistry, Mice, Cognition, Geranylgeranylation, Neurobiology, Alzheimer Disease, Memory, medicine, Animals, Farnesyltranstransferase, Molecular Biology, Neuroinflammation, Genetics, Amyloid beta-Peptides, biology, Brain, Cell Biology, medicine.disease, Cell biology, Disease Models, Animal, Proteolysis, Synaptic plasticity, biology.protein, Protein farnesylation, Protein prenylation, Alzheimer's disease, Gene Deletion

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::29d4ca729e459473f01e37ba28378736Test
https://doi.org/10.1074/jbc.m113.503904Test

المؤلفون: Emilia Rung, Håkan Billig, Christina Bergh, P. Anders Friberg

المصدر: Molecular Reproduction and Development. 73:1277-1283

مصطلحات موضوعية: Ovulation, medicine.medical_specialty, Protein Prenylation, Apoptosis, Quinolones, Biology, chemistry.chemical_compound, Hormone Antagonists, Prenylation, Geranylgeraniol, Leucine, Internal medicine, Progesterone receptor, Genetics, medicine, Farnesyltranstransferase, Humans, Estrenes, Furans, Cells, Cultured, Granulosa Cells, Cholesterol, Imidazoles, Cell Biology, Farnesol, Mifepristone, Endocrinology, chemistry, Simvastatin, Protein prenylation, Female, lipids (amino acids, peptides, and proteins), Lovastatin, Diterpenes, Hydroxymethylglutaryl-CoA Reductase Inhibitors, Receptors, Progesterone, Developmental Biology, medicine.drug

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c66cd1018b02516a5c5c97a5f2f1cffaTest
https://doi.org/10.1002/mrd.20551Test

المؤلفون: Michele Caraglia, Pierfrancesco Tassone, Salvatore Venuta, Pierosandro Tagliaferri, Alfredo Budillon, Alberto Abbruzzese, Giovanni Vitale, M. Marra, Anna Maria D'Alessandro, Annamaria Colao, G. Giuberti, Caterina Viscomi, Salvatore Del Prete

المساهمون: M., Caraglia, A. M., D'Alessandro, M., Marra, G., Giuberti, G., Vitale, C., Viscomi, Colao, Annamaria, S. D., Prete, P., Tagliaferri, P., Tassone, A., Budillon, Venuta, Salvatore, A., Abbruzzese, Caraglia, Michele, D'Alessandro, A. M., Marra, M., Giuberti, G., Vitale, G., Viscomi, C., Colao, A., Prete, S., Tagliaferri, P., Tassone, P., Budillon, A., Venuta, S., ABBRUZZESE SACCARDI, A.

المصدر: Oncogene. 23:6900-6913

مصطلحات موضوعية: MAPK/ERK pathway, bisphosphonate, Cancer Research, Settore MED/06 - Oncologia Medica, Pamidronate, Apoptosis, Quinolones, Zoledronic Acid, KB Cells, Settore MED/13 - Endocrinologia, chemistry.chemical_compound, Epidermal growth factor, Akt, Bisphosphonates, Epidermoid cancer, Farnesyl transferase inhibitor, Ras, Enzyme Inhibitors, Diphosphonates, Farnesyl Transferase Inhibitor, Imidazoles, Drug Synergism, Caspases, Mitogen-Activated Protein Kinases, Growth inhibition, Cell Division, hormones, hormone substitutes, and hormone antagonists, medicine.medical_specialty, Protein Prenylation, Protein Serine-Threonine Kinases, Biology, Proto-Oncogene Proteins, Internal medicine, Genetics, medicine, Farnesyltranstransferase, Humans, Molecular Biology, Protein kinase B, Alkyl and Aryl Transferases, Epidermal Growth Factor, apoptosi, Endocrinology, chemistry, Cancer cell, Cancer research, Protein prenylation, aminobisphosphonate, Proto-Oncogene Proteins c-akt

وصف الملف: ELETTRONICO

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c5b2be62b94dec6f1aec222f7c69082Test
https://doi.org/10.1038/sj.onc.1207814Test

المؤلفون: Mohammed S. Inayat, Swatee Dey, Mansoor M. Ahmed, George D. Hartman, Mohammed Mohiuddin, Damodaran Chendil, Rachael A Alcock, Lee Chatfield, Vincent S. Gallicchio

المصدر: Oncogene. 21:7883-7890

مصطلحات موضوعية: Cyclin-Dependent Kinase Inhibitor p21, DNA (Cytosine-5-)-Methyltransferase 1, Radiation-Sensitizing Agents, Cancer Research, endocrine system diseases, Recombinant Fusion Proteins, Receptor expression, Protein Prenylation, Apoptosis, Adenocarcinoma, Protein Serine-Threonine Kinases, Regulatory Sequences, Nucleic Acid, Biology, Radiation Tolerance, Proto-Oncogene Proteins p21(ras), Methionine, Radiation sensitivity, Transforming Growth Factor beta, Cyclins, Genetics, Farnesyltranstransferase, Humans, DNA (Cytosine-5-)-Methyltransferases, Enzyme Inhibitors, Molecular Biology, Alkyl and Aryl Transferases, Farnesyltransferase inhibitor, Receptor, Transforming Growth Factor-beta Type II, Transforming growth factor beta, DNA Methylation, digestive system diseases, Neoplasm Proteins, Gene Expression Regulation, Neoplastic, Pancreatic Neoplasms, Genes, ras, Cell culture, Enzyme Induction, Cancer research, biology.protein, Protein prenylation, Signal transduction, Protein Processing, Post-Translational, Receptors, Transforming Growth Factor beta, Signal Transduction

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c28cbf45dd410c8a543cc4a172950af5Test
https://doi.org/10.1038/sj.onc.1205948Test

المؤلفون: Shao H. Yang, Brandon S.J. Davies, Stephen G. Young, Hea-Jin Jung, Loren G. Fong

المصدر: Science translational medicine. 5(171)

مصطلحات موضوعية: congenital, hereditary, and neonatal diseases and abnormalities, Cell Nucleus Shape, Farnesyltransferase, Protein Prenylation, Biology, Article, chemistry.chemical_compound, Therapeutic approach, Progeria, medicine, Animals, Farnesyltranstransferase, Humans, Lonafarnib, Enzyme Inhibitors, Genetics, Clinical Trials as Topic, integumentary system, Farnesyltransferase inhibitor, nutritional and metabolic diseases, General Medicine, medicine.disease, Lamins, chemistry, Cancer research, biology.protein, Protein prenylation, Lamin

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db510109528d95da88cb2a8522744c1bTest
https://pubmed.ncbi.nlm.nih.gov/23390246Test

المؤلفون: Tim D. Hewitson, Kristen J. Kelynack, Rosemary Masterson, Gavin J. Becker

المصدر: Nephron Experimental Nephrology. 102:e19-e29

مصطلحات موضوعية: Nephrology, medicine.medical_specialty, Time Factors, Physiology, Protein Prenylation, Apoptosis, Rho family of GTPases, In Vitro Techniques, Kidney, Collagen Type I, Immediate-Early Proteins, Geranylgeranylation, Prenylation, Internal medicine, Genetics, medicine, Animals, Farnesyltranstransferase, RNA, Messenger, Enzyme Inhibitors, Fibroblast, Cytoskeleton, Cell Proliferation, Alkyl and Aryl Transferases, biology, Farnesyltransferase inhibitor, Connective Tissue Growth Factor, General Medicine, Fibroblasts, Fibrosis, In vitro, Rats, Cell biology, Collagen Type I, alpha 1 Chain, Actin Cytoskeleton, Kinetics, medicine.anatomical_structure, Biochemistry, Benzamides, ras Proteins, biology.protein, Intercellular Signaling Peptides and Proteins, Collagen, Guanosine Triphosphate

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9652255eca22b55b8835cdf350047083Test
https://doi.org/10.1159/000088403Test