دورية أكاديمية
Phenobarbital pharmacological findings on the nerve-muscle basis
| العنوان: | Phenobarbital pharmacological findings on the nerve-muscle basis |
|---|---|
| المؤلفون: | Rubem-Mauro, Leandro, Rocha Jr, Dimas S., Barcelos, Caroline C., Costa Varca, Gustavo H., Andréo Filho, Newton, Barberato Fihlo, Silvio, Oshima-Franco, Yoko, Vila, Marta M. D. C. |
| سنة النشر: | 2009 |
| المجموعة: | Universidad Nacional de La Plata (UNLP): SeDiCI (Servicio de Difusión de la Creación Intelectual) |
| مصطلحات موضوعية: | Farmacia, Medicamento, antiepileptic drugs, neuromuscular junction, pharmacologic actions, Sistema Nervioso Central |
| الوصف: | Phenobarbital and carbamazepine are antiepileptic drugs that act at the nervous central system by different mechanisms of action. In this work we investigated the pharmacological effects of these drugs on mouse phrenic nerve-diaphragm preparations through the myographic technique. Carbamazepine (0.105, 1.05, 2.1 and 4.2 mM, n = 8, 6, 6 and 6, respectively), induced a dose-dependent neuromuscular blockade, under indirect or direct muscle stimulation and the neurotransmission was reestablished after washing. Conversely, phenobarbital caused an unexpected facilitatory effect, under several formulations, such as the acid-extracted commercial tablets (1.05, 2.1 and 4.2 mM, n = 7, 6 and 7, respectively), commercial phenobarbital solution (4.2 mM, n = 7) or its correspondent pure active ingredient (4.2 and 2.1 mM, n = 6 each). Only at a higher concentration the acid-extracted phenobarbital performed a neuromuscular blockade (8.4 mM, n = 10). The different responses between carbamazepine (paralysis) and phenobarbital (facilitatory effect) evidentiated a new effect for phenobarbital until now concealed at the neuromuscular junction and may involve the glutamatergic regulation, since its role as an acetylcholine co-transmitter in motoneurons was already established. ; Colegio de Farmacéuticos de la Provincia de Buenos Aires |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | 211-218 |
| اللغة: | English |
| العلاقة: | http://sedici.unlp.edu.ar/handle/10915/7748Test; http://www.latamjpharm.org/trabajos/28/2/LAJOP_28_2_1_7_0F5VI3J8T0.pdfTest |
| الإتاحة: | http://sedici.unlp.edu.ar/handle/10915/7748Test http://www.latamjpharm.org/trabajos/28/2/LAJOP_28_2_1_7_0F5VI3J8T0.pdfTest |
| رقم الانضمام: | edsbas.3800D781 |
| قاعدة البيانات: | BASE |
| الوصف غير متاح. |