Is chromosome radiosensitivity and apoptotic response to irradiation correlated with cancer susceptibility?
| العنوان: | Is chromosome radiosensitivity and apoptotic response to irradiation correlated with cancer susceptibility? |
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| المؤلفون: | Laurent Pangon, Sarah Rose, Jonathan Berg, Shirley Hodgson, J Barwell, Richard Camplejohn, Caroline Langman, Zoe Docherty, Jan Ball, Anne Georgiou, Ian Kesterton, Ruth Gilchrist |
| المصدر: | International Journal of Radiation Biology. 83:1-12 |
| بيانات النشر: | Informa UK Limited, 2007. |
| سنة النشر: | 2007 |
| مصطلحات موضوعية: | Oncology, medicine.medical_specialty, Pathology, Neoplasms, Radiation-Induced, Time Factors, Lymphocyte, Apoptosis, Biology, Radiation Tolerance, Ionizing radiation, Breast cancer, Internal medicine, medicine, Chromosomes, Human, Humans, Radiology, Nuclear Medicine and imaging, Lymphocytes, Radiosensitivity, Family history, Radiation, Radiological and Ultrasound Technology, Chromosome, medicine.disease, medicine.anatomical_structure, Case-Control Studies, Female, Disease Susceptibility, Chromosome breakage |
| الوصف: | Individuals who have been treated for breast cancer have been reported to have increased lymphocyte chromosomal sensitivity to ionizing radiation and a significantly lower apoptotic response to irradiation compared to controls. We set out to test these findings using a substantial number of cases sampled before treatment (which could alter the parameters measured), compared to age-matched controls with normal mammograms.We used the G2 chromosome breakage, and apoptotic response assays of peripheral blood lymphocytes to ionizing radiation to compare 211 unselected newly diagnosed and untreated breast cancer patients, with 170 age, sex and ethnically matched controls.We found no significant differences between breast cancer patients and their matched controls in the G2 assay or apoptotic response. However, there was some evidence that both cases and controls with a strong family history of breast cancer had higher radiosensitivity than those without.This is the largest and best controlled study of its kind, but it has not replicated previous reports of differences between chromosome breakage or apoptotic response in breast cancer cases vs. controls. However there was a suggestion of increased radiosensitivity in patients with a strong family history, which may indicate a heritable cancer susceptibility trait, warranting further study. |
| تدمد: | 1362-3095 0955-3002 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::53f5f176f4a4d60e63c8043661d9016cTest https://doi.org/10.1080/09553000600932968Test |
| رقم الانضمام: | edsair.doi.dedup.....53f5f176f4a4d60e63c8043661d9016c |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 13623095 09553002 |
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