المؤلفون: Deding, Ulrik, Kaalby, Lasse, Steele, Robert, Al-Najami, Issam, Kobaek-Larsen, Morten, Plantener, Eva, Madsen, Jeppe B., Madsen, Jonna S., Bjørsum-Meyer, Thomas, Baatrup, Gunnar

المصدر: Deding , U , Kaalby , L , Steele , R , Al-Najami , I , Kobaek-Larsen , M , Plantener , E , Madsen , J B , Madsen , J S , Bjørsum-Meyer , T & Baatrup , G 2023 , ' Faecal haemoglobin concentration predicts all-cause mortality ' , European Journal of Cancer , vol. 184 , pp. 21-29 . https://doi.org/10.1016/j.ejca.2023.02.009Test

مصطلحات موضوعية: Colorectal cancer, Colorectal cancer mortality, Faecal immunochemical test, Screening, All-cause mortality, FIT, Colonoscopy, /dk/atira/pure/subjectarea/asjc/2700/2730, name=Oncology, /dk/atira/pure/subjectarea/asjc/1300/1306, name=Cancer Research

الوصف: Background : Population-based screening for colorectal cancer by a faecal immunochemical test (FIT) is recommended by the European Union. Detectable faecal haemoglobin can indicate colorectal neoplasia as well as other conditions. A positive FIT predicts an increased risk of death from colorectal cancer but might also predict an increased risk of all-cause mortality. Methods : A cohort of screening participants was followed using the Danish National Register of Causes of Death. Data were retrieved from the Danish Colorectal Cancer Screening Database supplemented with FIT concentrations. Colorectal cancer specific and all-cause mortality were compared between FIT concentration groups using multivariate cox proportional hazards regression models. Findings : In 444,910 Danes invited for the screening program, 25,234 (5·7%) died during a mean follow-up of 56·5 months. Colorectal cancer caused 1120 deaths. The risk of colorectal cancer death increased with the increasing FIT concentration. The hazard ratios ranged from 2·6 to 25·9 compared to individuals with FIT concentrations <4 μg hb/g faeces. Causes other than colorectal cancer caused 24,114 deaths. The risk of all-cause death increased with the increasing FIT concentration, with the hazard ratios ranging from 1·6 to 5·3 compared to individuals with FIT concentrations <4 μg hb/g faeces. Interpretation : The risk of colorectal cancer mortality increased with the increasing FIT concentrations even for FIT concentrations considered negative in all European screening programs. The risk of all-cause mortality was also increased for individuals with detectable faecal blood. For colorectal cancer specific mortality and all-cause mortality, the risk was increased at the FIT concentrations as low as 4-9 μg hb/g faeces.

وصف الملف: application/pdf

العلاقة: https://discovery.dundee.ac.uk/en/publications/60bee7a2-9dbd-49a9-8e99-e81f7df8ea4bTest

الإتاحة: https://doi.org/10.1016/j.ejca.2023.02.009Test
https://discovery.dundee.ac.uk/en/publications/60bee7a2-9dbd-49a9-8e99-e81f7df8ea4bTest
https://discovery.dundee.ac.uk/ws/files/99096797/1_s2.0_S0959804923000862_main.pdfTest
http://www.scopus.com/inward/record.url?scp=85150785877&partnerID=8YFLogxKTest

المؤلفون: Kaalby, Lasse, Deding, Ulrik, Al-Najami, Issam, Berg-Beckhoff, Gabriele, Bjørsum-Meyer, Thomas, Laurberg, Tinne, Shaukat, Aasma, Steele, Robert J. C., Koulaouzidis, Anastasios, Rasmussen, Morten, Kobaek-Larsen, Morten, Baatrup, Gunnar

المصدر: Kaalby , L , Deding , U , Al-Najami , I , Berg-Beckhoff , G , Bjørsum-Meyer , T , Laurberg , T , Shaukat , A , Steele , R J C , Koulaouzidis , A , Rasmussen , M , Kobaek-Larsen , M & Baatrup , G 2023 , ' Faecal haemoglobin concentrations are associated with all-cause mortality and cause of death in colorectal cancer screening ' , BMC Medicine , vol. 21 , 29 . https://doi.org/10.1186/s12916-022-02724-3Test

مصطلحات موضوعية: cause of death, colorectal cancer screening, faecal immunochemical test, faecal haemoglobin, mortality, occult blood, /dk/atira/pure/subjectarea/asjc/2700/2700, name=General Medicine

الوصف: Background : Colorectal cancer (CRC) screening reduces all-cause and CRC-related mortality. New research demonstrates that the faecal haemoglobin concentration (f-Hb) may indicate the presence of other serious diseases not related to CRC. We investigated the association between f-Hb, measured by a faecal immunochemical test (FIT), and both all-cause mortality and cause of death in a population-wide cohort of screening participants. Methods: Between 2014 and 2018, 1,262,165 participants submitted a FIT for the Danish CRC screening programme. We followed these participants, using the Danish CRC Screening Database and several other national registers on health and population, until December 31, 2018. We stratified participants by f-Hb and compared them using a Cox proportional hazards regression on all-cause mortality and cause of death reported as adjusted hazard ratios (aHRs). We adjusted for several covariates, including comorbidity, socioeconomic factors, demography and prescription medication. Results : We observed 21,847 deaths in the study period. Our multivariate analyses indicated an association relationship between increasing f-Hb and the risk of dying in the study period. This risk increased steadily from aHR 1.38 (95% CI: 1.32, 1.44) in those with a f-Hb of 7.1-11.9 μg Hb/g faeces to 2.20 (95% CI: 2.10, 2.30) in those with a f-Hb ≥60.0 μg Hb/g faeces, when compared to those with a f-Hb ≤7.0 μg Hb/g faeces. The pattern remained when excluding CRC from the analysis. Similar patterns were observed between incrementally increasing f-Hb and the risk of dying from respiratory disease, cardiovascular disease and cancers other than CRC. Furthermore, we observed an increased risk of dying from CRC with increasing f-Hb. Conclusions : Our findings support the hypothesis that f-Hb may indicate an elevated risk of having chronic conditions if causes for the bleeding have not been identified. The mechanisms still need to be established, but f-Hb may be a potential biomarker for several non-CRC diseases.

وصف الملف: application/pdf

العلاقة: https://discovery.dundee.ac.uk/en/publications/2755e7a0-38ea-4475-b91f-c67e6c937846Test

الإتاحة: https://doi.org/10.1186/s12916-022-02724-3Test
https://discovery.dundee.ac.uk/en/publications/2755e7a0-38ea-4475-b91f-c67e6c937846Test
https://discovery.dundee.ac.uk/ws/files/95006742/s12916_022_02724_3.pdfTest
http://www.scopus.com/inward/record.url?scp=85146793661&partnerID=8YFLogxKTest